A Location-Aware Middleware Framework for Collaborative Visual Information Discovery and Retrieval

This work addresses the problem of scalable location-aware distributed indexing to enable the leveraging of collaborative effort for the construction and maintenance of world-scale visual maps and models which could support numerous activities including navigation, visual localization, persistent surveillance, structure from motion, and hazard or disaster detection. Current distributed approaches to mapping and modeling fail to incorporate global geospatial addressing and are limited in their functionality to customize search. Our solution is a peer-to-peer middleware framework based on XOR distance routing which employs a Hilbert Space curve addressing scheme in a novel distributed geographic index. This allows for a universal addressing scheme supporting publish and search in dynamic environments while ensuring global availability of the model and scalability with respect to geographic size and number of users. The framework is evaluated using large-scale network simulations and a search application that supports visual navigation in real-world experiments

Screened poisson hyperfields for shape coding

We present a novel perspective on shape characterization using the screened Poisson equation. We discuss that the effect of the screening parameter is a change of measure of the underlying metric space. Screening also indicates a conditioned random walker biased by the choice of measure. A continuum of shape fields is created by varying the screening parameter or, equivalently, the bias of the random walker. In addition to creating a regional encoding of the diffusion with a different bias, we further break down the influence of boundary interactions by considering a number of independent random walks, each emanating from a certain boundary point, whose superposition yields the screened Poisson field. Probing the screened Poisson equation from these two complementary perspectives leads to a high-dimensional hyperfield: a rich characterization of the shape that encodes global, local, interior, and boundary interactions. To extract particular shape information as needed in a compact way from the hyperfield, we apply various decompositions either to unveil parts of a shape or parts of a boundary or to create consistent mappings. The latter technique involves lower-dimensional embeddings, which we call screened Poisson encoding maps (SPEM). The expressive power of the SPEM is demonstrated via illustrative experiments as well as a quantitative shape retrieval experiment over a public benchmark database on which the SPEM method shows a high-ranking performance among the existing state-of-the-art shape retrieval methods

Server-Aided Privacy-Preserving Proximity Testing

Proximity testing is at the core of many Location-Based online Services (LBS) which we use in our daily lives to order taxis, find places of interest nearby, connect with people. Currently, most such services expect a user to submit his location to them and trust the LBS not to abuse this information, and use it only to provide the service. Existing cases of such information being misused (e.g., by the LBS employees or criminals who breached its security) motivates the search for better solutions that would ensure the privacy of user data, and give users control of how their data is being used.In this thesis, we address this problem using cryptographic techniques. We propose three cryptographic protocols that allow two users to perform proximity testing (check if they are close enough to each other) with the help of two servers.In the papers 1 and 2, the servers are introduced in order to allow users not to be online at the same time: one user may submit their location to the servers and go offline, the other user coming online later and finishing proximity testing. The drastically improves the practicality of such protocols, since the mobile devices that users usually run may not always be online. We stress that the servers in these protocols merely aid the users in performing the proximity testing, and none of the servers can independently extract the user data.In the paper 3, we use the servers to offload the users\u27 computation and communication to. The servers here pre-generate correlated random data and send it to users, who can use it to perform a secure proximity testing protocol faster. Paper 3, together with the paper 2, are highly practical: they provide strong security guarantees and are suitable to be executed on resource-constrained mobile devices. In fact, the work of clients in these protocols is close to negligible as most of the work is done by servers

Efficient Change Management of XML Documents

XML-based documents play a major role in modern information architectures and their corresponding work-flows. In this context, the ability to identify and represent differences between two versions of a document is essential. A second important aspect is the merging of document versions, which becomes crucial in parallel editing processes. Many different approaches exist that meet these challenges. Most rely on operational transformation or document annotation. In both approaches, the operations leading to changes are tracked, which requires corresponding editing applications. In the context of software development, however, a state-based approach is common. Here, document versions are compared and merged using external tools, called diff and patch. This allows users for freely editing documents without being tightened to special tools. Approaches exist that are able to compare XML documents. A corresponding merge capability is still not available. In this thesis, I present a comprehensive framework that allows for comparing and merging of XML documents using a state-based approach. Its design is based on an analysis of XML documents and their modification patterns. The heart of the framework is a context-oriented delta model. I present a diff algorithm that appears to be highly efficient in terms of speed and delta quality. The patch algorithm is able to merge document versions efficiently and reliably. The efficiency and the reliability of my approach are verified using a competitive test scenario

Table Augmentation in Data Lakes

Data lakes are centralized repositories that store large quantities of raw, unstructured, and structured data, allowing for ad-hoc data analysis, exploratory data analysis, and machine learning. However, the lack of metadata and schema in data lakes makes it challenging to work with tabular data and find related information stored in different tables. However, it is still an open problem how efficiently retrieve these tables at large scale when the settings of a data lake holds. The thesis introduces a novel approach to table augmentation that enables efficient data integration from multiple sources in a data lake. Table augmentation involves adding new data to an existing table in a horizontal fashion (by retrieving tables that can be horizontally concatenated to a query that serves as query table). The proposed approach consists of several components, including data lakes hashing, join search, similarity, and augmentation. The proposed approach is named TASH. TASH is a framework based on a spatial index in which tables are mapped and queried. Its goal is to identify the most useful columns for subsequent machine learning tasks. The table retrieval process employs a combination of set containment search and similarity search. Candidate tables are initially identified using set containment search and then ranked based on their similarity to the query. Experimental results demonstrate that TASH can effectively identify joinable tables and select the most relevant features, thereby enabling efficient table augmentation in data lakes. This research contributes to the field of big data by providing a practical solution to the challenges of data integration and analysis in data lake environments

Mining a Small Medical Data Set by Integrating the Decision Tree and t-test

[[abstract]]Although several researchers have used statistical methods to prove that aspiration followed by the injection of 95% ethanol left in situ (retention) is an effective treatment for ovarian endometriomas, very few discuss the different conditions that could generate different recovery rates for the patients. Therefore, this study adopts the statistical method and decision tree techniques together to analyze the postoperative status of ovarian endometriosis patients under different conditions. Since our collected data set is small, containing only 212 records, we use all of these data as the training data. Therefore, instead of using a resultant tree to generate rules directly, we use the value of each node as a cut point to generate all possible rules from the tree first. Then, using t-test, we verify the rules to discover some useful description rules after all possible rules from the tree have been generated. Experimental results show that our approach can find some new interesting knowledge about recurrent ovarian endometriomas under different conditions.[[journaltype]]國外[[incitationindex]]EI[[booktype]]紙本[[countrycodes]]FI

Computational Approaches to Drug Profiling and Drug-Protein Interactions

Despite substantial increases in R&D spending within the pharmaceutical industry, denovo drug design has become a time-consuming endeavour. High attrition rates led to a long period of stagnation in drug approvals. Due to the extreme costs associated with introducing a drug to the market, locating and understanding the reasons for clinical failure is key to future productivity. As part of this PhD, three main contributions were made in this respect. First, the web platform, LigNFam enables users to interactively explore similarity relationships between ‘drug like’ molecules and the proteins they bind. Secondly, two deep-learning-based binding site comparison tools were developed, competing with the state-of-the-art over benchmark datasets. The models have the ability to predict offtarget interactions and potential candidates for target-based drug repurposing. Finally, the open-source ScaffoldGraph software was presented for the analysis of hierarchical scaffold relationships and has already been used in multiple projects, including integration into a virtual screening pipeline to increase the tractability of ultra-large screening experiments. Together, and with existing tools, the contributions made will aid in the understanding of drug-protein relationships, particularly in the fields of off-target prediction and drug repurposing, helping to design better drugs faster

FUN3D Manual: 12.7

This manual describes the installation and execution of FUN3D version 12.7, including optional dependent packages. FUN3D is a suite of computational fluid dynamics simulation and design tools that uses mixed-element unstructured grids in a large number of formats, including structured multiblock and overset grid systems. A discretely-exact adjoint solver enables efficient gradient-based design and grid adaptation to reduce estimated discretization error. FUN3D is available with and without a reacting, real-gas capability. This generic gas option is available only for those persons that qualify for its beta release status

FUN3D Manual: 12.6

This manual describes the installation and execution of FUN3D version 12.6, including optional dependent packages. FUN3D is a suite of computational fluid dynamics simulation and design tools that uses mixed-element unstructured grids in a large number of formats, including structured multiblock and overset grid systems. A discretely-exact adjoint solver enables efficient gradient-based design and grid adaptation to reduce estimated discretization error. FUN3D is available with and without a reacting, real-gas capability. This generic gas option is available only for those persons that qualify for its beta release status

FUN3D Manual: 12.5

This manual describes the installation and execution of FUN3D version 12.5, including optional dependent packages. FUN3D is a suite of computational uid dynamics simulation and design tools that uses mixed-element unstructured grids in a large number of formats, including structured multiblock and overset grid systems. A discretely-exact adjoint solver enables ecient gradient-based design and grid adaptation to reduce estimated discretization error. FUN3D is available with and without a reacting, real-gas capability. This generic gas option is available only for those persons that qualify for its beta release status