Electromagnetic radiation from ingested sources in the human intestine between 150 MHz and 1.2 GHz

The conventional method of diagnosing disorders of the human gastro-intestinal (GI) tract is by sensors embedded in cannulae that are inserted through the anus, mouth, or nose. However, these cannulae cause significant patient discomfort and cannot be used in the small intestine. As a result, there is considerable ongoing work in developing wireless sensors that can be used in the small intestine. The radiation characteristics of sources in the GI tract cannot be readily calculated due to the complexity of the human body and its composite tissues, each with different electrical characteristics. In addition, the compact antennas used are electrically small, making them inefficient radiators. This paper presents radiation characteristics for sources in the GI tract that should allow for the optimum design of more efficient telemetry systems. The characteristics are determined using the finite-difference time-domain method with a realistic antenna model on an established fully segmented human body model. Radiation intensity outside the body was found to have a Gaussian-form relationship with frequency. Maximum radiation occurs between 450 and 900 MHz. The gut region was found generally to inhibit vertically polarized electric fields more than horizontally polarized fields

Super-regenerative receiver at 433MHz

This paper presents a receiver for operation in the 433 MHz ISM band. The selected architecture explores the super regeneration phenomena to achieve a high sensitivity for applying in wireless implantable microsystems. This radio frequency (RF) chip can be supplied with a voltage of only 3 V for demodulating signals with powers in the range [ 100, 40] dB. The codulation (modulation and coding) scheme of the binary data is a variation of the Manchester code combined with OOK (on/off keying) modulation. The AMIS 0.7 µm CMOS process was selected for targeting the requirement to fabricate a low cost receiver, whose prototype was integrated in a die with an area of 55 mm2. Also, this receiver is fully compatibility with commercially transmitters for the same frequency

Hand palm local channel characterization for millimeter-wave body-centric applications

The body-centric wireless channel characterization mostly utilizes whole body models. However, localized channels for body parts consistently interacting with the wireless device have their own importance. This paper attempts to characterize the hand palm local channel through experimental measurements at three millimeter-wave frequency bands of 27-28 GHz, 29-30 GHz, and 31-32 GHz. Five human subjects are used in this study. Net body loss is found to be 3dB for different subjects with subject-specific and varying palm shape size is found to be the primary affecting source. The repeatability of the on-body propagation measurements is found to be within 10% of variance

Antennas and Propagation of Implanted RFIDs for Pervasive Healthcare Applications

© 2010 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.This post-acceptance version of the paper is essentially complete, but may differ from the official copy of record, which can be found at the following web location (subscription required to access full paper): http://dx.doi.org/10.1109/JPROC.2010.205101

Miniature implantable antennas for biomedical telemetry: from simulation to realization

WOS:000310154700019 (Nº de Acesso Web of Science)“Prémio Científico ISCTE-IUL 2013”We address numerical versus experimental design and testing of miniature implantable antennas for biomedical telemetry in the medical implant communications service band (402-405 MHz). A model of a novel miniature antenna is initially proposed for skin implantation, which includes varying parameters to deal with fabrication-specific details. An iterative design-and-testing methodology is further suggested to determine the parameter values that minimize deviations between numerical and experimental results. To assist in vitro testing, a low-cost technique is proposed for reliably measuring the electric properties of liquids without requiring commercial equipment. Validation is performed within a specific prototype fabrication/testing approach for miniature antennas. To speed up design while providing an antenna for generic skin implantation, investigations are performed inside a canonical skin-tissue model. Resonance, radiation, and safety performance of the proposed antenna is finally evaluated inside an anatomical head model. This study provides valuable insight into the design of implantable antennas, assessing the significance of fabrication-specific details in numerical simulations and uncertainties in experimental testing for miniature structures. The proposed methodology can be applied to optimize antennas for several fabrication/testing approaches and biotelemetry applications

Spatial In-Body Channel Characterization Using an Accurate UWB Phantom

"(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works."Ultra-wideband (UWB) systems have emerged as a possible solution for future wireless in-body communications. However, in-body channel characterization is complex. Animal experimentation is usually restricted. Furthermore, software simulations can be expensive and imply a high computational cost. Synthetic chemical solutions, known as phantoms, can be used to solve this issue. However, achieving a reliable UWB phantom can be challenging since UWB systems use a large bandwidth and the relative permittivity of human tissues are frequency dependent. In this paper, a measurement campaign within 3.1-8.5 GHz using a new UWB phantom is performed. Currently, this phantom achieves the best known approximation to the permittivity of human muscle in the whole UWB band. Measurements were performed in different spatial positions, in order to also investigate the diversity of the in-body channel in the spatial domain. Two experimental in-body to in-body (IB2IB) and in-body to on-body (IB2OB) scenarios are considered. From the measurements, new path loss models are obtained. Besides, the correlation in transmission and reception is computed for both scenarios. Our results show a highly uncorrelated channel in transmission for the IB2IB scenario at all locations. Nevertheless, for the IB2OB scenario, the correlation varies depending on the position of the receiver and transmitter.This work was supported by the Ministerio de Economia y Competitividad, Spain, under Grant TEC2014-60258-C2-1-R and Grant TEC2014-56469-REDT and by the European FEDER Funds.Andreu Estellés, C.; Castelló Palacios, S.; García Pardo, C.; Fornés Leal, A.; Vallés Lluch, A.; Cardona Marcet, N. (2016). Spatial In-Body Channel Characterization Using an Accurate UWB Phantom. IEEE Transactions on Microwave Theory and Techniques. 64(11):3995-4002. doi:10.1109/TMTT.2016.2609409S39954002641

Development of piezoresistive sensors for biomedical applications

Tese de doutoramento em Engenharia Electrónica Industrial e de ComputadoresIn the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles.In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. Sensors with larger flexibility were also developed though inkjet printing technique. Various configurations and materials were used to evaluate which materials are most appropriate for these types of sensors. Sensors with a gauge factor of approximately 2.5 for an active layer of PeDOT were obtained. A sensor matrix of 4 x 5 sensors was fabricated with an active area of 1.8 x 1.5 mm2 per sensor. These sensors were subjected to a set of electromechanical tests to evaluate its performance in situations close to end use. So the prosthesis was coated with the various sensors, cemented and subjected to deformation cycles for three levels of force according to standard ISO7206. An adaptive system read-out electronic circuit was developed and built that allows reading piezoresistive sensors with different characteristics. This system allows measuring a matrix of 8x8 sensors, but can be scaled to a large number of sensors. The readable range of the system is between 50 Ω and 100 kΩ according to the needs of the sensors being implanted. The total area of the circuit is 135 mm2, according to the requirements of a circuit to be used in in-vivo applications. An energy management system was also implemented that allows to activate and deactivate parts of the circuit when they are not needed, reducing the energy consumption. The system was validated by measuring a matrix of sensors with different characteristics. Finally, simulations were performed in order to evaluate the best options for the development of a wireless communications system. Three possible operation frequency ranges were used for three types of standard antennas. The communication system was introduced into a model simulating the characteristics of the various layers that constitute the human body. These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics.These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics. Neste trabalho foi desenvolvido um modelo de prótese de anca com implementação de sensores. Para atingir esse objectivo, foram desenvolvidos sensores piezoresitivos flexíveis que permitam ser implantados. Assim foram fabricados sensores de deformação baseados em filmes finos de n+-nc-si.H pela técnica de hot-wire chemical vapor deposition a uma temperatura de 150ºC sobre um substrato polimérico. Recorreu-se a técnica de litografia para construir as várias camadas do sensor. Os sensores apresentam um gauge factor de -28, para ciclos de baixa frequência em testes de four-point-bending. Foram ainda desenvolvidos sensores com uma maior flexibilidade através da técnica de inkjet printing. Para esse desenvolvimento foram usadas várias configurações e materiais, para avaliar quais os materiais mais adequados para este tipo de sensores. Na caracterização destes sensores obteve-se um gauge factor de aproximadamente 2.5 para uma camada ativa de PeDOT. Com os melhores sensores obtidos foram construídas matrizes de 4 x 5 sensores que apresentam uma área ativa de 1.8 x 1.5mm2 por sensor. Estes sensores foram sujeitos a um conjunto de ensaios electromecânicos, para avaliar o seu desempenho em situações próximas da utilização final. Desta forma foi revestida uma prótese com os diferentes sensores, cimentada e sujeita a ciclos de deformação para três níveis de força, segundo a norma ISO7206. Foi desenvolvido e construído um sistema de leitura adaptável que permite medir sensores piezoresistivos com diferentes características entre eles. Este sistema permite medir uma matriz de 8x8 sensores, mas pode ser escalada para um número maior de sensores. A gama de leitura do sistema varia entre 50 Ω e 100 kΩ, de acordo com as necessidades dos sensores a serem implementados. A área total deste circuito é de 135 mm2, de acordo com as necessidades de um circuito a ser utilizado em aplicações in-vivo. Foi também implementado um sistema de gestão de energia que permite ativar e desativar partes do circuito quando estas não são necessárias, permitindo, desta forma, reduzir os consumos de energia. O sistema foi validado através da medição de uma matriz de sensores com diferentes características. foram realizadas simulações de forma a avaliar as melhores opções para o desenvolvimento do sistema de comunicação sem fios. Foram usadas três possíveis gamas de frequência de operação para três tipos de antenas standard. O sistema de comunicação foi introduzido num modelo simulando as características das várias camadas que constituem o corpo humano. Estas simulações permitem aferir a gama de frequências mais adequadas para os dispositivos implantáveis, a antena mais adequada e a sua melhor localização, pois foi verificado como as várias camadas que constituem o corpo humano influenciam a comunicação. Assim, a frequência escolhida para a implementação foi de 868 MHz e a antena foi a IFA. Em conclusão, os elementos principais para a implementação de uma prótese de anca instrumentada, foram desenvolvidos e validados. Os elementos desenvolvidos e/ou simulados, incluindo os sensores, circuitos de leitura e sistema de comunicação, poderão igualmente ser utilizados em outras aplicações devido às suas boas características

Body-UAV Near-Ground LoRa Links through a Mediterranean Forest

LoRa low-power wide-area network protocol has recently gained attention for deploying ad-hoc search and rescue (SaR) systems. They could be empowered by exploiting body-UAV links that enable communications between a body-worn radio and a UAV-mounted one. However, to employ UAVs effectively, knowledge of the signal's propagation in the environment is required. Otherwise, communications and localization could be hindered. The radio range, the packet delivery ratio (PDR), and the large- and small-scale fading of body-UAV LoRa links at 868 MHz when the radio wearer is in a Mediterranean forest are here characterized for the first time with a near-ground UAV having a maximum flying height of 30 m. A log-distance model accounting for the body shadowing and the wearer's movements is derived. Over the full LoRa radio range of about 600 m, the new model predicts the path loss (PL) better than the state-of-the-art ones, with a reduction of the median error even by 10 dB. The observed small-scale fading is severe and follows a Nakagami-m distribution. Extensions of the model for similar scenarios can be drawn through appropriate corrective factors

Design, realization and measurements of a miniature antenna for implantable wireless communication systems

The design procedure, realization and measurements of an implantable radiator for telemetry applications are presented. First, free space analysis allows the choice of the antenna typology with reduced computation time. Subsequently the antenna, inserted in a body phantom, is designed to take into account all the necessary electronic components, power supply and bio-compatible insulation so as to realize a complete implantable device. The conformal design has suitable dimensions for subcutaneous implantation (10 x 32.1 mm). The effect of different body phantoms is discussed. The radiator works in both the Medical Device Radiocommunication Service (MedRadio, 401-406 MHz) and the Industrial, Scientific and Medical (ISM, 2.4-2.5 GHz) bands. Simulated maximum gains attain and -28.8 and -18.5 dBi in the two desired frequency ranges, respectively, when the radiator is implanted subcutaneously in a homogenous cylindrical body phantom (80 x 110 mm) with muscle equivalent dielectric properties. Three antennas are realized and characterized in order to improve simulation calibration, electromagnetic performance, and to validate the repeatability of the manufacturing process. Measurements are also presented and a good correspondence with theoretical predictions is registered