Maximising the mutual interoperability of an MRI scanner and a cancer therapy particle accelerator

The work described in this PhD thesis was undertaken as part of a much larger research project: The Australian MRI-Linac program. The goal of this program is to merge two existing medical technologies – an MRI scanner and a Linear Accelerator (Linac) – thereby creating an advanced form of cancer treatment incorporating cutting edge anatomical and physiological imaging techniques. An overview of the background information necessary to understand the work presented in this thesis is provided in chapters 1 (overview of radiotherapy) and 2 (overview of electromagnetism and accelerator physics). The work in the remainder of this thesis can be split into two distinct sections, corresponding to the two quite different (but ultimately related) projects I worked on throughout this thesis: modelling the impact of external magnetic fields on electron beam transport within the linear accelerator, and the implementation of patient rotation in radiotherapy. The former project is the focus of Chapters 3-6. In Chapter 3 a finite element model of a clinical gridded electron gun is developed based on 3D laser scanning and electrical measurements, and the sensitivity of this gun in magnetic fields characterised. The results complement the existing literature in showing that conventional linear accelerator components are very sensitive to external magnetic fields – in fact this gun is over twice as sensitive to axial magnetic fields than the less realistic models existing in the literature. A first order approach to overcoming this sensitivity is to use magnetic shielding – however magnetic shielding of the linear accelerator can negatively impact on the performance of the MRI scanner. This magnetic shielding problem is explored in Chapter 4, where the fundamental principles of passive magnetic shielding are explored, and magnetic shields are implemented for the two possible MRI-linac configurations (in-line and perpendicular) for the 1.0 Tesla MRI magnet used in the Australian MRI Linac program. The efficacy of the shielding and the impact on the MRI is quantified, with the conclusion that passive shielding could be successfully implemented to allow acceptable operation of the linac without overly degrading the magnet performance of the MRI scanner. An alternative approach to magnetic shielding which would not have any impact on the magnet is to redesign the linear accelerator such that it functions robustly in an MRI environment without the need for shielding. This approach is explored in chapter 5, where a novel electron accelerator concept based on an RF-electron gun configuration is detailed. It is shown via particle in cell simulations that such a design would be able to operate in a wide range of axial magnetic fields with minimal current loss. In chapter 6, an experimental beam line based on this concept was constructed at Stanford Linear Accelerator Center (SLAC). This project is ongoing but progress so far is described in Chapter 6. In the second part of this thesis, a completely different project is explored, patient rotation. Patient rotation would be very beneficial for MRI-Linac systems as it would eliminate the complicated engineering that is used in conventional systems to rotate the beam around the patient, and the MRI could be used to adapt in real time for the resultant anatomic deformation. Patient rotation would also minimise some of the sources of electromagnetic interference explored in chapters 3-7. The two major obstacles to patient rotation are (1) Page 11 patient tolerance to rotation, and (2) anatomical deformation due to rotation. To quantify patient rotation, a clinical study of 15 patients was carried out and is detailed in chapter 7. The results of this study suggest that patient tolerance to rotation may not be a major issue, although this result needs to be verified in larger patient cohorts. In chapter 8, the design and construction of an MRI-compatible patient rotation device is detailed. This device is the first of its kind, and will allow data on anatomic deformation under rotation to be collected, enabling strategies to adapt for this motion to be developed. Thus far, MRI compatibility has been assessed and a volunteer imaging study undertaken, in which pelvic images were acquired under rotation angles of 360⁰ every 45⁰. In summary: In chapters 3-5, the impact of magnetic fields on conventional accelerator components was quantified; and two independent approaches to compensating for these effects (magnetic shielding and bespoke accelerator design) were explored. In chapter 6, an experimental beam is constructed to verify and support the findings of chapter 6. In chapter 7, a clinical study was undertaken quantifying patient tolerance of slow, single arc rotation. Finally, in chapter 8 a unique medical device was designed, constructed and tested, and through this device MRI images of anatomical distortion under lying rotation were collected and quantified

Scientific Opportunities with an X-ray Free-Electron Laser Oscillator

An X-ray free-electron laser oscillator (XFELO) is a new type of hard X-ray source that would produce fully coherent pulses with meV bandwidth and stable intensity. The XFELO complements existing sources based on self-amplified spontaneous emission (SASE) from high-gain X-ray free-electron lasers (XFEL) that produce ultra-short pulses with broad-band chaotic spectra. This report is based on discussions of scientific opportunities enabled by an XFELO during a workshop held at SLAC on June 29 - July 1, 2016Comment: 21 pages, 12 figure

Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

Radiation therapy is currently the most utilized technique for the treatment of tumors by means ofionizing radiation, such as electrons, protons and x/gamma rays, depending on the type, size and depth ofthe cancer mass. Radiation therapy has in general fulfilled the main requirement of targeting thus damagingthe malignant cells and sparing the healthy tissues as best as possible. In this scenario, electron linearaccelerators have been operated as viable tools for the delivery of both high-energetic electrons and x-raybeams, which are obtained via the bremsstrahlung process of the electrons hitting on a high-Z material.Recently, it has been experimentally demonstrated that ultrahigh dose-rate bursts of electrons and x-raybeams increase the differential response between healthy and tumor tissues. This beneficial response isreferred to as the FLASH effect. For this purpose, we have developed the first dedicated compactS-bandlinear accelerator for FLASH radiotherapy. This linac is optimized for a nominal energy of 7 MeV and apulsed electron beam current of 100 mA and above. The accelerator is mounted on a remote-controlledsystem for preclinical research studies in the FLASH regime. We will show the rf and beam dynamicsdesign of theS-band linac as well as the commissioning and high-power rf tests. Furthermore, the results ofthe dosimetric measurements will be illustrate

Development of RF accelerating structures in the front-end system of light ion particle accelerators

The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) is an RF linear accelerator-based neutron source which utilizes various RF cavity resonators to interact with a traveling particle beam to transfer energy to the beam. The RF cavity resonator generates a strong electromagnetic modal field specifically shaped at an operating frequency to provide good energy efficiency. Having a reliable cavity RF field is therefore, important to sustain performance and stable operation of the accelerator system. Although the SNS system is already built and in use, some parts still need to be improved to achieve better performance and higher operational reliability. Our study can provide potential improvements in existing accelerators as well as future ones. For example, the performance and reliability of the radio frequency quadrupole (RFQ) and the rebuncher cavities in the low beam energy front-end section of the SNS accelerators, have been improved by applying our newly proposed design ideas. In this dissertation, we propose four development directions for RFQ and rebuncher cavity to enhance its performance and field stabilization. These include: 1) a practical design method to determine RFQ fabrication tolerance based on extensive 3D simulations to help reduce RFQ fabrication errors. 2) alternative RFQ designs to improve RFQ mode separation with lower fabrication, tuning costs and structural reliability. 3) a multi-section RFQ with new RF coupling scheme which is validated with scaled prototyping. This design eliminates spurious electromagnetic modes and can decrease manufacturing and tuning costs of long coupled RFQs. 4) a double gap rebuncher cavity design instead of a single cavity for decreased gap voltage and peak electric field. This design modification can reduce X-ray radiation intensity which can address safety problems in the current accelerator front-end area. A summary of our proposed solutions and contributions are presented in this dissertation paper

Development of a solid state amplifier for the 3rd harmonic cavity for ALBA synchrotron light source

In Synchrotron Light Source facilities with high energy and low emittance electron beams different techniques for improving the quality of the synchrotron light for the users are applied. With this aim ALBA, the Spanish 3rd generation Synchrotron Light Source, is developing a 3rd Harmonic radiofrequency (RF) system as a system additional to the main RF system of the storage ring. This system will consist of four normal conducting active cavities at 1.5 GHz that will provide the required 1.1 MV accelerating voltage to the electron beam and will be fed by four 20 kW power transmitters. This power will be generated by modular Solid State Power Amplifiers (SSPAs) in a continuous wave mode at 1.5 GHz. On the basis of preliminary studies it has been decided that the architecture of each 20 kW power transmitter is a tree diagram made up of primary 1 kW SSPA modules connected in parallel in a combination array. The present PhD thesis is devoted to the design, building and evaluation of a prototype of the 1 kW SSPA module formed four 250 W primary power amplifier modules. Accordingly, all subsystems, namely input and output matching networks of the 250 W primary module, and a four-way power splitter, a four-way power combiner and a novel directivity compensated directional coupler for the non-invasive power monitoring of the 1 kW power amplifier were also designed and their prototypes were tested. A final evaluation of the combined 1 kW SSPA prototype module was successfully carried out and has shown good performance.En las instalaciones de tipo Fuentes de luz de sincrotrón de haz de electrones de alta energía y baja emitancia se aplican diferentes técnicas de mejora de la calidad de la luz de sincrotrón. Con este objetivo, el ALBA, la fuente española de luz de sincrotrón de la tercera generación, está desarrollando un sistema de radiofrecuencia (RF) de la 3ª Harmónica como un sistema adicional al sistema de RF principal del anillo de almacenamiento. Este sistema consistirá de cuatro cavidades activas de conductividad normal de frecuencia 1,5 GHz que suministrarán un voltaje acelerador de 1.1 MV necesario para el haz de electrones y que serán alimentadas por cuatro transmisores de potencia de 20 kW. Esta potencia será generada en modo de onda continua a frecuencia 1.5 GHz por amplificadores de potencia de estado sólido (APES) de estructura modular. A partir de unos estudios preliminares se ha decidido que la arquitectura de cada transmisor de potencia de 20 kW es de tipo diagrama de árbol que consiste de APES primarios de potencia 1 kW conectados en paralelo formando una matriz de combinación. El tema de la presente tesis es el diseño, la construcción y la caracterización de un prototipo del módulo de APES de potencia 1 kW formado por cuatro amplificadores primarios de 250 W de potencia. También, todos subsistemas, concretamente los circuitos de adaptación de entrada y de salida del módulo primario de 250 kW, así como un divisor de cuatro salidas, un combinador de cuatro entradas y un acoplador direccional con una nova solución de compensación de directividad para una monitorización no invasiva han sido diseñados y sus prototipos han sido testeados. La evaluación final de funcionamiento del APES de 1 kW de potencia ha sido realizada con éxito y ha demostrado su buen rendimiento.Postprint (published version

Development of a solid state amplifier for the 3rd harmonic cavity for ALBA synchrotron light source

In Synchrotron Light Source facilities with high energy and low emittance electron beams different techniques for improving the quality of the synchrotron light for the users are applied. With this aim ALBA, the Spanish 3rd generation Synchrotron Light Source, is developing a 3rd Harmonic radiofrequency (RF) system as a system additional to the main RF system of the storage ring. This system will consist of four normal conducting active cavities at 1.5 GHz that will provide the required 1.1 MV accelerating voltage to the electron beam and will be fed by four 20 kW power transmitters. This power will be generated by modular Solid State Power Amplifiers (SSPAs) in a continuous wave mode at 1.5 GHz. On the basis of preliminary studies it has been decided that the architecture of each 20 kW power transmitter is a tree diagram made up of primary 1 kW SSPA modules connected in parallel in a combination array. The present PhD thesis is devoted to the design, building and evaluation of a prototype of the 1 kW SSPA module formed four 250 W primary power amplifier modules. Accordingly, all subsystems, namely input and output matching networks of the 250 W primary module, and a four-way power splitter, a four-way power combiner and a novel directivity compensated directional coupler for the non-invasive power monitoring of the 1 kW power amplifier were also designed and their prototypes were tested. A final evaluation of the combined 1 kW SSPA prototype module was successfully carried out and has shown good performance.En las instalaciones de tipo Fuentes de luz de sincrotrón de haz de electrones de alta energía y baja emitancia se aplican diferentes técnicas de mejora de la calidad de la luz de sincrotrón. Con este objetivo, el ALBA, la fuente española de luz de sincrotrón de la tercera generación, está desarrollando un sistema de radiofrecuencia (RF) de la 3ª Harmónica como un sistema adicional al sistema de RF principal del anillo de almacenamiento. Este sistema consistirá de cuatro cavidades activas de conductividad normal de frecuencia 1,5 GHz que suministrarán un voltaje acelerador de 1.1 MV necesario para el haz de electrones y que serán alimentadas por cuatro transmisores de potencia de 20 kW. Esta potencia será generada en modo de onda continua a frecuencia 1.5 GHz por amplificadores de potencia de estado sólido (APES) de estructura modular. A partir de unos estudios preliminares se ha decidido que la arquitectura de cada transmisor de potencia de 20 kW es de tipo diagrama de árbol que consiste de APES primarios de potencia 1 kW conectados en paralelo formando una matriz de combinación. El tema de la presente tesis es el diseño, la construcción y la caracterización de un prototipo del módulo de APES de potencia 1 kW formado por cuatro amplificadores primarios de 250 W de potencia. También, todos subsistemas, concretamente los circuitos de adaptación de entrada y de salida del módulo primario de 250 kW, así como un divisor de cuatro salidas, un combinador de cuatro entradas y un acoplador direccional con una nova solución de compensación de directividad para una monitorización no invasiva han sido diseñados y sus prototipos han sido testeados. La evaluación final de funcionamiento del APES de 1 kW de potencia ha sido realizada con éxito y ha demostrado su buen rendimiento

Enhanced European Coordination of Accelerator Research and Development – EuCARD2 – global and local impact

Wide scale, European, infrastructural research projects on accelerator science and technology are under realization since 2003. CARE project was realized during the period 2003/4-2008, and next EuCARD during 2009-2013. Now during 2014-2017 there is successfully continued EuCARD2 – Enhanced European Coordination of Accelerator R&D. European accelerator R&D community prepares next continuation of the EuCARD inside the Horizon 2020. The paper presents the work developments of EuCARD. Several institutions from Poland are participating in EuCARD: NCNR in Świerk, IChTJ, technical Universites in Łódź, Wrocław and Warsaw. Realization of the project during the last 12 years gave numerable and valuable results combined with essential modernization of the European research infrastructures. From the point of view of domestic interests, where we do not have large research infrastructures, the considerable benefits are associated with  the participation of young researchers from Poland – engineers and physicists, in building of the top research infrastructures. Due to such participation, high technologies are developed in several centres in the country. The EuCARD project organizes annual meetings summarizing periodically the R&D advances. The EuCARD AM2015 was held in Barcelona in April

Compact radio-frequency quadrupoles for industrial and medical applications

This thesis involves the development of two radio-frequency quadrupole particle accelerators (RFQ) operating at 750 MHz. The first part covers radio-frequency (RF) design studies of the proton PIXE-RFQ. RF measurement results and tuning procedure are presented, showing very good agreement with simulations. The second part reports the development of the Carbon-RFQ for cancer therapy. The Carbon-RFQ features trapezoidal vanes whose fields are described using a novel semi-analytic approach. Dipole modes were detuned by a novel cavity length adjustment technique.Die vorliegende Dissertation beschäftigt sich mit der Entwicklung zweier 750 MHz Hochfrequenzquadrupol-Teilchenbeschleuniger (RFQ). Der erste Teil umfasst Hochfrequenz (HF)-Designstudien des PIXE-RFQ. HF-Messergebnisse und Abstimmungsverfahren werden vorgestellt, die eine sehr gute Übereinstimmung mit Simulationen zeigen. Der zweite Teil beschreibt die Entwicklung des Carbon-RFQ für die Krebstherapie. Die Felder seiner trapezförmige Elektroden werden mittels eines neuartigen semi-analytischen Ansatzes beschrieben. Die Dipolmoden wurden durch Anpassung der RFQ-Gesamtlänge verstimmt

Technologies for Delivery of Proton and Ion Beams for Radiotherapy

Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we review the historical development of particle accelerators used for external beam radiotherapy and discuss the more recent progress towards more capable and cost-effective sources of particles.Comment: 53 pages, 13 figures. Submitted to International Journal of Modern Physics