11,926 research outputs found
Bayesian Approximate Kernel Regression with Variable Selection
Nonlinear kernel regression models are often used in statistics and machine
learning because they are more accurate than linear models. Variable selection
for kernel regression models is a challenge partly because, unlike the linear
regression setting, there is no clear concept of an effect size for regression
coefficients. In this paper, we propose a novel framework that provides an
effect size analog of each explanatory variable for Bayesian kernel regression
models when the kernel is shift-invariant --- for example, the Gaussian kernel.
We use function analytic properties of shift-invariant reproducing kernel
Hilbert spaces (RKHS) to define a linear vector space that: (i) captures
nonlinear structure, and (ii) can be projected onto the original explanatory
variables. The projection onto the original explanatory variables serves as an
analog of effect sizes. The specific function analytic property we use is that
shift-invariant kernel functions can be approximated via random Fourier bases.
Based on the random Fourier expansion we propose a computationally efficient
class of Bayesian approximate kernel regression (BAKR) models for both
nonlinear regression and binary classification for which one can compute an
analog of effect sizes. We illustrate the utility of BAKR by examining two
important problems in statistical genetics: genomic selection (i.e. phenotypic
prediction) and association mapping (i.e. inference of significant variants or
loci). State-of-the-art methods for genomic selection and association mapping
are based on kernel regression and linear models, respectively. BAKR is the
first method that is competitive in both settings.Comment: 22 pages, 3 figures, 3 tables; theory added; new simulations
presented; references adde
Marginal integration for nonparametric causal inference
We consider the problem of inferring the total causal effect of a single
variable intervention on a (response) variable of interest. We propose a
certain marginal integration regression technique for a very general class of
potentially nonlinear structural equation models (SEMs) with known structure,
or at least known superset of adjustment variables: we call the procedure
S-mint regression. We easily derive that it achieves the convergence rate as
for nonparametric regression: for example, single variable intervention effects
can be estimated with convergence rate assuming smoothness with
twice differentiable functions. Our result can also be seen as a major
robustness property with respect to model misspecification which goes much
beyond the notion of double robustness. Furthermore, when the structure of the
SEM is not known, we can estimate (the equivalence class of) the directed
acyclic graph corresponding to the SEM, and then proceed by using S-mint based
on these estimates. We empirically compare the S-mint regression method with
more classical approaches and argue that the former is indeed more robust, more
reliable and substantially simpler.Comment: 40 pages, 14 figure
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