Quantitative Robustness Analysis of Flat Timed Automata

Whereas formal verification of timed systems has become a very active field of research, the idealized mathematical semantics of timed automata cannot be faithfully implemented. Recently, several works have studied a parametric semantics of timed automata related to implementability: if the specification is met for some positive value of the parameter, then there exists a correct implementation. In addition, the value of the parameter gives lower bounds on sufficient resources for the implementation. In this work, we present a symbolic algorithm for the computation of the parametric reachability set under this semantics for flat timed automata. As a consequence, we can compute the largest value of the parameter for a timed automaton to be safe

Time-Staging Enhancement of Hybrid System Falsification

Optimization-based falsification employs stochastic optimization algorithms to search for error input of hybrid systems. In this paper we introduce a simple idea to enhance falsification, namely time staging, that allows the time-causal structure of time-dependent signals to be exploited by the optimizers. Time staging consists of running a falsification solver multiple times, from one interval to another, incrementally constructing an input signal candidate. Our experiments show that time staging can dramatically increase performance in some realistic examples. We also present theoretical results that suggest the kinds of models and specifications for which time staging is likely to be effective

A Theory of Sampling for Continuous-time Metric Temporal Logic

This paper revisits the classical notion of sampling in the setting of real-time temporal logics for the modeling and analysis of systems. The relationship between the satisfiability of Metric Temporal Logic (MTL) formulas over continuous-time models and over discrete-time models is studied. It is shown to what extent discrete-time sequences obtained by sampling continuous-time signals capture the semantics of MTL formulas over the two time domains. The main results apply to "flat" formulas that do not nest temporal operators and can be applied to the problem of reducing the verification problem for MTL over continuous-time models to the same problem over discrete-time, resulting in an automated partial practically-efficient discretization technique.Comment: Revised version, 43 pages

On the robustness of temporal properties for stochastic models

Stochastic models such as Continuous-Time Markov Chains (CTMC) and Stochastic Hybrid Automata (SHA) are powerful formalisms to model and to reason about the dynamics of biological systems, due to their ability to capture the stochasticity inherent in biological processes. A classical question in formal modelling with clear relevance to biological modelling is the model checking problem. i.e. calculate the probability that a behaviour, expressed for instance in terms of a certain temporal logic formula, may occur in a given stochastic process. However, one may not only be interested in the notion of satisfiability, but also in the capacity of a system to mantain a particular emergent behaviour unaffected by the perturbations, caused e.g. from extrinsic noise, or by possible small changes in the model parameters. To address this issue, researchers from the verification community have recently proposed several notions of robustness for temporal logic providing suitable definitions of distance between a trajectory of a (deterministic) dynamical system and the boundaries of the set of trajectories satisfying the property of interest. The contributions of this paper are twofold. First, we extend the notion of robustness to stochastic systems, showing that this naturally leads to a distribution of robustness scores. By discussing two examples, we show how to approximate the distribution of the robustness score and its key indicators: the average robustness and the conditional average robustness. Secondly, we show how to combine these indicators with the satisfaction probability to address the system design problem, where the goal is to optimize some control parameters of a stochastic model in order to best maximize robustness of the desired specifications

On the expressiveness of MTL variants over dense time

Abstract. The basic modal operator bounded until of Metric Temporal Logic (MTL) comes in several variants. In particular it can be strict (when it does not constrain the current instant) or not, and matching (when it requires its two arguments to eventually hold together) or not. This paper compares the relative expressiveness of the resulting MTL variants over dense time. We prove that the expressiveness is not affected by the variations when considering non-Zeno interpretations and arbitrary nesting of temporal operators. On the contrary, the expressiveness changes for flat (i.e., without nesting) formulas, or when Zeno interpretations are allowed.

Systems Biology of Cancer: A Challenging Expedition for Clinical and Quantitative Biologists

A systems-biology approach to complex disease (such as cancer) is now complementing traditional experience-based approaches, which have typically been invasive and expensive. The rapid progress in biomedical knowledge is enabling the targeting of disease with therapies that are precise, proactive, preventive, and personalized. In this paper, we summarize and classify models of systems biology and model checking tools, which have been used to great success in computational biology and related fields. We demonstrate how these models and tools have been used to study some of the twelve biochemical pathways implicated in but not unique to pancreatic cancer, and conclude that the resulting mechanistic models will need to be further enhanced by various abstraction techniques to interpret phenomenological models of cancer progression

Computer Aided Verification

This open access two-volume set LNCS 11561 and 11562 constitutes the refereed proceedings of the 31st International Conference on Computer Aided Verification, CAV 2019, held in New York City, USA, in July 2019. The 52 full papers presented together with 13 tool papers and 2 case studies, were carefully reviewed and selected from 258 submissions. The papers were organized in the following topical sections: Part I: automata and timed systems; security and hyperproperties; synthesis; model checking; cyber-physical systems and machine learning; probabilistic systems, runtime techniques; dynamical, hybrid, and reactive systems; Part II: logics, decision procedures; and solvers; numerical programs; verification; distributed systems and networks; verification and invariants; and concurrency