A shared-parameter continuous-time hidden Markov and survival model for longitudinal data with informative dropout

A shared-parameter approach for jointly modeling longitudinal and survival data is proposed. With respect to available approaches, it allows for time-varying random effects that affect both the longitudinal and the survival processes. The distribution of these random effects is modeled according to a continuous-time hidden Markov chain so that transitions may occur at any time point. For maximum likelihood estimation, we propose an algorithm based on a discretization of time until censoring in an arbitrary number of time windows. The observed information matrix is used to obtain standard errors. We illustrate the approach by simulation, even with respect to the effect of the number of time windows on the precision of the estimates, and by an application to data about patients suffering from mildly dilated cardiomyopathy

Mixed hidden Markov quantile regression models for longitudinal data with possibly incomplete sequences

Quantile regression provides a detailed and robust picture of the distribution of a response variable, conditional on a set of observed covariates. Recently, it has be been extended to the analysis of longitudinal continuous outcomes using either time-constant or time-varying random parameters. However, in real-life data, we frequently observe both temporal shocks in the overall trend and individual-specific heterogeneity in model parameters. A benchmark dataset on HIV progression gives a clear example. Here, the evolution of the CD4 log counts exhibits both sudden temporal changes in the overall trend and heterogeneity in the effect of the time since seroconversion on the response dynamics. To accommodate such situations, we propose a quantile regression model, where time-varying and time-constant random coefficients are jointly considered. Since observed data may be incomplete due to early drop-out, we also extend the proposed model in a pattern mixture perspective. We assess the performance of the proposals via a large-scale simulation study and the analysis of the CD4 count data

Prior elicitation in Bayesian quantile regression for longitudinal data

© 2011 Alhamzawi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original auhor and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.In this paper, we introduce Bayesian quantile regression for longitudinal data in terms of informative priors and Gibbs sampling. We develop methods for eliciting prior distribution to incorporate historical data gathered from similar previous studies. The methods can be used either with no prior data or with complete prior data. The advantage of the methods is that the prior distribution is changing automatically when we change the quantile. We propose Gibbs sampling methods which are computationally efficient and easy to implement. The methods are illustrated with both simulation and real data.This article is made available through the Brunel Open Access Publishing Fund

Longitudinal quantile regression in presence of informative drop-out through longitudinal-survival joint modeling

We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables. Our joint model provides a flexible approach to handle informative drop-out in quantile regression. A general Monte Carlo Expectation Maximization strategy based on importance sampling is proposed, which is directly applicable under any distributional assumption for the longitudinal outcome and random effects, and parametric and non-parametric assumptions for the baseline hazard. Model properties are illustrated through a simulation study and an application to an original data set about dilated cardiomyopathies

A partially collapsed Gibbs sampler for Bayesian quantile regression

We introduce a set of new Gibbs sampler for Bayesian analysis of quantile re-gression model. The new algorithm, which partially collapsing an ordinary Gibbs sampler, is called Partially Collapsed Gibbs (PCG) sampler. Although the Metropolis-Hastings algorithm has been employed in Bayesian quantile regression, including median regression, PCG has superior convergence properties to an ordinary Gibbs sampler. Moreover, Our PCG sampler algorithm, which is based on a theoretic derivation of an asymmetric Laplace as scale mixtures of normal distributions, requires less computation than the ordinary Gibbs sampler and can significantly reduce the computation involved in approximating the Bayes Factor and marginal likelihood. Like the ordinary Gibbs sampler, the PCG sample can also be used to calculate any associated marginal and predictive distributions. The quantile regression PCG sampler is illustrated by analysing simulated data and the data of length of stay in hospital. The latter provides new insight into hospital perfor-mance. C-code along with an R interface for our algorithms is publicly available on request from the first author. JEL classification: C11, C14, C21, C31, C52, C53