Enhancing CFD predictions in shape design problems by model and parameter space reduction

In this work we present an advanced computational pipeline for the approximation and prediction of the lift coefficient of a parametrized airfoil profile. The non-intrusive reduced order method is based on dynamic mode decomposition (DMD) and it is coupled with dynamic active subspaces (DyAS) to enhance the future state prediction of the target function and reduce the parameter space dimensionality. The pipeline is based on high-fidelity simulations carried out by the application of finite volume method for turbulent flows, and automatic mesh morphing through radial basis functions interpolation technique. The proposed pipeline is able to save 1/3 of the overall computational resources thanks to the application of DMD. Moreover exploiting DyAS and performing the regression on a lower dimensional space results in the reduction of the relative error in the approximation of the time-varying lift coefficient by a factor 2 with respect to using only the DMD

Enhancing CFD predictions in shape design problems by model and parameter space reduction

In this work we present an advanced computational pipeline for the approximation and prediction of the lift coefficient of a parametrized airfoil profile. The non-intrusive reduced order method is based on dynamic mode decomposition (DMD) and it is coupled with dynamic active subspaces (DyAS) to enhance the future state prediction of the target function and reduce the parameter space dimensionality. The pipeline is based on high-fidelity simulations carried out by the application of finite volume method for turbulent flows, and automatic mesh morphing through radial basis functions interpolation technique. The proposed pipeline is able to save 1/3 of the overall computational resources thanks to the application of DMD. Moreover exploiting DyAS and performing the regression on a lower dimensional space results in the reduction of the relative error in the approximation of the time-varying lift coefficient by a factor 2 with respect to using only the DMD

Joint and individual analysis of breast cancer histologic images and genomic covariates

A key challenge in modern data analysis is understanding connections between complex and differing modalities of data. For example, two of the main approaches to the study of breast cancer are histopathology (analyzing visual characteristics of tumors) and genetics. While histopathology is the gold standard for diagnostics and there have been many recent breakthroughs in genetics, there is little overlap between these two fields. We aim to bridge this gap by developing methods based on Angle-based Joint and Individual Variation Explained (AJIVE) to directly explore similarities and differences between these two modalities. Our approach exploits Convolutional Neural Networks (CNNs) as a powerful, automatic method for image feature extraction to address some of the challenges presented by statistical analysis of histopathology image data. CNNs raise issues of interpretability that we address by developing novel methods to explore visual modes of variation captured by statistical algorithms (e.g. PCA or AJIVE) applied to CNN features. Our results provide many interpretable connections and contrasts between histopathology and genetics

Hull Shape Design Optimization with Parameter Space and Model Reductions, and Self-Learning Mesh Morphing

In the field of parametric partial differential equations, shape optimization represents a challenging problem due to the required computational resources. In this contribution, a data-driven framework involving multiple reduction techniques is proposed to reduce such computational burden. Proper orthogonal decomposition (POD) and active subspace genetic algorithm (ASGA) are applied for a dimensional reduction of the original (high fidelity) model and for an efficient genetic optimization based on active subspace property. The parameterization of the shape is applied directly to the computational mesh, propagating the generic deformation map applied to the surface (of the object to optimize) to the mesh nodes using a radial basis function (RBF) interpolation. Thus, topology and quality of the original mesh are preserved, enabling application of POD-based reduced order modeling techniques, and avoiding the necessity of additional meshing steps. Model order reduction is performed coupling POD and Gaussian process regression (GPR) in a data-driven fashion. The framework is validated on a benchmark ship

Dimension reduction in heterogeneous parametric spaces with application to naval engineering shape design problems

We present the results of the first application in the naval architecture field of a methodology based on active subspaces properties for parameter space reduction. The physical problem considered is the one of the simulation of the hydrodynamic flow past the hull of a ship advancing in calm water. Such problem is extremely relevant at the preliminary stages of the ship design, when several flow simulations are typically carried out by the engineers to assess the dependence of the hull total resistance on the geometrical parameters of the hull, and others related with flows and hull properties. Given the high number of geometric and physical parameters which might affect the total ship drag, the main idea of this work is to employ the active subspaces properties to identify possible lower dimensional structures in the parameter space. Thus, a fully automated procedure has been implemented to produce several small shape perturbations of an original hull CAD geometry, in order to exploit the resulting shapes and to run high fidelity flow simulations with different structural and physical parameters as well, and then collect data for the active subspaces analysis. The free form deformation procedure used to morph the hull shapes, the high fidelity solver based on potential flow theory with fully nonlinear free surface treatment, and the active subspaces analysis tool employed in this work have all been developed and integrated within SISSA mathLab as open source tools. The contribution will also discuss several details of the implementation of such tools, as well as the results of their application to the selected target engineering problem

Combined parameter and model reduction of cardiovascular problems by means of active subspaces and POD-Galerkin methods

In this chapter we introduce a combined parameter and model reduction methodology and present its application to the efficient numerical estimation of a pressure drop in a set of deformed carotids. The aim is to simulate a wide range of possible occlusions after the bifurcation of the carotid. A parametric description of the admissible deformations, based on radial basis functions interpolation, is introduced. Since the parameter space may be very large, the first step in the combined reduction technique is to look for active subspaces in order to reduce the parameter space dimension. Then, we rely on model order reduction methods over the lower dimensional parameter subspace, based on a POD-Galerkin approach, to further reduce the required computational effort and enhance computational efficiency