The cognitive neuroscience of visual working memory

Visual working memory allows us to temporarily maintain and manipulate visual information in order to solve a task. The study of the brain mechanisms underlying this function began more than half a century ago, with Scoville and Milner’s (1957) seminal discoveries with amnesic patients. This timely collection of papers brings together diverse perspectives on the cognitive neuroscience of visual working memory from multiple fields that have traditionally been fairly disjointed: human neuroimaging, electrophysiological, behavioural and animal lesion studies, investigating both the developing and the adult brain

High-fidelity imaging : the computational models of the human visual system in high dynamic range video compression, visible difference prediction and image processing

As new displays and cameras offer enhanced color capabilities, there is a need to extend the precision of digital content. High Dynamic Range (HDR) imaging encodes images and video with higher than normal bit-depth precision, enabling representation of the complete color gamut and the full visible range of luminance. This thesis addresses three problems of HDR imaging: the measurement of visible distortions in HDR images, lossy compression for HDR video, and artifact-free image processing. To measure distortions in HDR images, we develop a visual difference predictor for HDR images that is based on a computational model of the human visual system. To address the problem of HDR image encoding and compression, we derive a perceptually motivated color space for HDR pixels that can efficiently encode all perceivable colors and distinguishable shades of brightness. We use the derived color space to extend the MPEG-4 video compression standard for encoding HDR movie sequences. We also propose a backward-compatible HDR MPEG compression algorithm that encodes both a low-dynamic range and an HDR video sequence into a single MPEG stream. Finally, we propose a framework for image processing in the contrast domain. The framework transforms an image into multi-resolution physical contrast images (maps), which are then rescaled in just-noticeable-difference (JND) units. The application of the framework is demonstrated with a contrast-enhancing tone mapping and a color to gray conversion that preserves color saliency.Aktuelle Innovationen in der Farbverarbeitung bei Bildschirmen und Kameras erzwingen eine Präzisionserweiterung bei digitalen Medien. High Dynamic Range (HDR) kodieren Bilder und Video mit einer grösseren Bittiefe pro Pixel, und ermöglichen damit die Darstellung des kompletten Farbraums und aller sichtbaren Helligkeitswerte. Diese Arbeit konzentriert sich auf drei Probleme in der HDR-Verarbeitung: Messung von für den Menschen störenden Fehlern in HDR-Bildern, verlustbehaftete Kompression von HDR-Video, und visuell verlustfreie HDR-Bildverarbeitung. Die Messung von HDR-Bildfehlern geschieht mittels einer Vorhersage von sichtbaren Unterschieden zweier HDR-Bilder. Die Vorhersage basiert dabei auf einer Modellierung der menschlichen Sehens. Wir addressieren die Kompression und Kodierung von HDR-Bildern mit der Ableitung eines perzeptuellen Farbraums für HDR-Pixel, der alle wahrnehmbaren Farben und deren unterscheidbaren Helligkeitsnuancen effizient abbildet. Danach verwenden wir diesen Farbraum für die Erweiterung des MPEG-4 Videokompressionsstandards, welcher sich hinfort auch für die Kodierung von HDR-Videosequenzen eignet. Wir unterbreiten weiters eine rückwärts-kompatible MPEG-Kompression von HDR-Material, welche die übliche YUV-Bildsequenz zusammen mit dessen HDRVersion in einen gemeinsamen MPEG-Strom bettet. Abschliessend erklären wir unser Framework zur Bildverarbeitung in der Kontrastdomäne. Das Framework transformiert Bilder in mehrere physikalische Kontrastauflösungen, um sie danach in Einheiten von just-noticeable-difference (JND, noch erkennbarem Unterschied) zu reskalieren. Wir demonstrieren den Nutzen dieses Frameworks anhand von einem kontrastverstärkenden Tone Mapping-Verfahren und einer Graukonvertierung, die die urspr ünglichen Farbkontraste bestmöglich beibehält

Oscillatory multiplexing of neural population codes for interval timing and working memory

Interval timing and working memory are critical components of cognition that are supported by neural oscillations in prefrontal-striatal-hippocampal circuits. In this review, the properties of interval timing and working memory are explored in terms of behavioral, anatomical, pharmacological, and neurophysiological findings. We then describe the various neurobiological theories that have been developed to explain these cognitive processes - largely independent of each other. Following this, a coupled excitatory - inhibitory oscillation (EIO) model of temporal processing is proposed to address the shared oscillatory properties of interval timing and working memory. Using this integrative approach, we describe a hybrid model explaining how interval timing and working memory can originate from the same oscillatory processes, but differ in terms of which dimension of the neural oscillation is utilized for the extraction of item, temporal order, and duration information. This extension of the striatal beat-frequency (SBF) model of interval timing (Matell and Meck, 2000, 2004) is based on prefrontal-striatal-hippocampal circuit dynamics and has direct relevance to the pathophysiological distortions observed in time perception and working memory in a variety of psychiatric and neurological conditions. (C) 2014 Elsevier Ltd. All rights reserved.</p

Auditory neural oscillations and excitation/inhibition balance in emerging psychosis

Chronic schizophrenia (ScZ) is associated with impaired gamma oscillations, reflected by robust alterations in 40 Hz ASSR. Oscillatory deficits may arise from changes in the cortical E/I-balance. However, it is unclear whether aberrant oscillations and potential underlying mechanisms are present also in early and clinical high risk (CHR) stages of psychosis. In this thesis, data from a multimodal CHR study were used to explore auditory oscillatory alterations in CHR individuals, assessed using MEG-recorded 40 Hz Auditory Steady State Response (ASSR) measures, with the aim to establish how deficits may account for early alterations in neural circuits in emerging psychosis. To further map such changes, a group of first episode of psychosis (FEP) participants were also studied, and oscillatory measures were compared with H1-MRS measures of neurotransmitter levels as well as with clinical measures. The thesis first presents a meta-analysis of ASSR findings in ScZ so far, showing that the response is impaired in chronic patients. Each of the following four chapters respectively present separate data analyses, focusing on baseline ASSR data, connectivity analyses, proton magnetic resonance spectroscopy (1H-MRS) analyses, and data assessing longitudinal outcomes. Through these investigations, the thesis demonstrates impairments in RSMG 40 Hz spectral power and ITPC in CHR and FEP, with bidirectional connectivity impairments present between RSMG and primary auditory cortex in CHR participants. In addition, strong beta frequency reductions in power were observed in CHR and FEP participants relative to controls. No clear impairments were detected in 1H-MRS data, but a trend deficit in right auditory GABA levels was seen in FEP patients. Finally, investigations of longitudinal parameters revealed that RSMG oscillatory impairments are related to functioning at the time of scanning, but not to functioning at the one-year follow-up. Moreover, beta frequency power was found to be selectively impaired in individuals with sustained CHR symptoms and low GAF scores (at both baseline and 12 months). Combined, the results of this thesis provide evidence for complex, subtle neural circuit alterations in emerging psychosis, which can be captured non-invasively using the 40 Hz ASSR paradigm