McNair Research Journal - Summer 2015

Journal articles based on research conducted by undergraduate students in the McNair Scholars Program Table of Contents Biography of Dr. Ronald E. McNair Statements: Dr. Neal J. Smatresk, UNLV President Dr. Juanita P. Fain, Vice President of Student Affairs Dr. William W. Sullivan, Associate Vice President for Retention and Outreach Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach McNair Scholars Institute Staf

Change blindness: eradication of gestalt strategies

Arrays of eight, texture-defined rectangles were used as stimuli in a one-shot change blindness (CB) task where there was a 50% chance that one rectangle would change orientation between two successive presentations separated by an interval. CB was eliminated by cueing the target rectangle in the first stimulus, reduced by cueing in the interval and unaffected by cueing in the second presentation. This supports the idea that a representation was formed that persisted through the interval before being 'overwritten' by the second presentation (Landman et al, 2003 Vision Research 43149–164]. Another possibility is that participants used some kind of grouping or Gestalt strategy. To test this we changed the spatial position of the rectangles in the second presentation by shifting them along imaginary spokes (by ±1 degree) emanating from the central fixation point. There was no significant difference seen in performance between this and the standard task [F(1,4)=2.565, p=0.185]. This may suggest two things: (i) Gestalt grouping is not used as a strategy in these tasks, and (ii) it gives further weight to the argument that objects may be stored and retrieved from a pre-attentional store during this task

Actor & Avatar: A Scientific and Artistic Catalog

What kind of relationship do we have with artificial beings (avatars, puppets, robots, etc.)? What does it mean to mirror ourselves in them, to perform them or to play trial identity games with them? Actor & Avatar addresses these questions from artistic and scholarly angles. Contributions on the making of "technical others" and philosophical reflections on artificial alterity are flanked by neuroscientific studies on different ways of perceiving living persons and artificial counterparts. The contributors have achieved a successful artistic-scientific collaboration with extensive visual material

Increasing rendering performance of graphics hardware

Graphics Processing Unit (GPU) performance is increasing faster than central processing unit (CPU) performance. This growth is driven by performance improvements that can be divided into the following three categories: algorithmic improvements, architectural improvements, and circuit-level improvements. In this dissertation I present techniques that improve the rendering performance of graphics hardware measured in speed, power consumption or image quality in each of these three areas. At the algorithmic level, I introduce a method for using graphics hardware to rapidly and efficiently generate summed-area tables, which are data structures that hold pre-computed two-dimensional integrals of subsets of a given image, and present several novel rendering techniques that take advantage of summed-area tables to produce dynamic, high-quality images at interactive frame rates. These techniques improve the visual quality of images rendered on current commodity GPUs without requiring modifications to the underlying hardware or architecture. At the architectural level, I propose modifications to the architecture of current GPUs that add conditional streaming capabilities. I describe a novel GPU-based ray-tracing algorithm that takes advantage of conditional output streams to reduce the memory bandwidth requirements by over an order of magnitude times when compared to previous techniques. At the circuit level, I propose a compute-on-demand paradigm for the design of high-speed and energy-efficient graphics components. The goal of the compute-on-demand paradigm is to only perform computation at the bit-level when needed. The compute-on-demand paradigm exploits the data-dependent nature of computation, and thereby obtains speed and energy improvements by optimizing designs for the common case. This approach is illustrated with the design of a high-speed Z-comparator that is implemented using asynchronous logic. Asynchronous or "clockless" circuits were chosen for my implementations since they allow for data-dependent completion times and reduced power consumption by disabling inactive components. The resulting circuit-level implementation runs over 1.5 times faster while on dissipating 25% the energy of a comparable synchronous comparator for the average case. Also at the circuit-level, I introduce a novel implementation of counterflow pipelining, which allows two streams of data to flow in opposite directions within the same pipeline without the need for complex arbitration. The advantages of this implementation are demonstrated by the design of a high-speed asynchronous Booth multiplier. While both the comparator and the multiplier are useful components of a graphics pipeline, the objective of this work was to propose the new design paradigm as a promising alternative to current graphics hardware design practices

Advances in Parvovirus Research 2020

Viruses of the Parvoviridae family constitute a most diverse and intriguing field of research. Parvoviruses can differ widely in their structure, genome organization and expression, virus–cell interactions, and impact on hosts. The translational implication of research on parvoviruses is relevant, since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and inherent complexity in the biology of these apparently simple viruses is a still challenging topic for the scientific community. The Special Issue of Viruses is a collection of recent contributions in the field of parvovirus research, encompassing many aspects of basic and translational research on viruses of the family Parvoviridae, including on their structure, replication, and gene expression in addition to virus–host interactions and the development of vaccines and viral vectors

Dichotomic role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells

Poster Presentation - Stem Cells and Pluripotency: abstract no. 1866The mobilization of intracellular Ca2+stores is involved in diverse cellular functions, including cell proliferation and differentiation. At least three endogenous Ca2+mobilizing messengers have been identified, including inositol trisphosphate (IP3), cyclic adenosine diphosphoribose (cADPR), and nicotinic adenine acid dinucleotide phosphate (NAADP). Similar to IP3, NAADP can mobilize calcium release in a wide variety of cell types and species, from plants to animals. Moreover, it has been previously shown that NAADP but not IP3-mediated Ca2+increases can potently induce neuronal differentiation in PC12 cells. Recently, two pore channels (TPCs) have been identified as a novel family of NAADP-gated calcium release channels in endolysosome. Therefore, it is of great interest to examine the role of TPC2 in the neural differentiation of mouse ES cells. We found that the expression of TPC2 is markedly decreased during the initial ES cell entry into neural progenitors, and the levels of TPC2 gradually rebound during the late stages of neurogenesis. Correspondingly, perturbing the NAADP signaling by TPC2 knockdown accelerates mouse ES cell differentiation into neural progenitors but inhibits these neural progenitors from committing to the final neural lineage. Interestingly, TPC2 knockdown has no effect on the differentiation of astrocytes and oligodendrocytes of mouse ES cells. Overexpression of TPC2, on the other hand, inhibits mouse ES cell from entering the neural lineage. Taken together, our data indicate that the NAADP/TPC2-mediated Ca2+signaling pathway plays a temporal and dichotomic role in modulating the neural lineage entry of ES cells; in that NAADP signaling antagonizes ES cell entry to early neural progenitors, but promotes late neural differentiation.postprin