Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age

Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood supply to the bone could enhance the understanding of bone strength determinants and fracture healing. Using synchrotron radiation-based computed tomography, the distribution of vascular canals and osteocyte lacunae was assessed in murine cortical bone and the influence of age on these parameters was investigated. The tibiofibular junction from 15-week- and 10-month-old female C57BL/6J mice were imaged post-mortem. Vascular canals and three-dimensional spatial relationships between osteocyte lacunae and bone surfaces were computed for both age groups. At 15 weeks, the posterior region of the tibiofibular junction had a higher vascular canal volume density than the anterior, lateral and medial regions. Intracortical vascular networks in anterior and posterior regions were also different, with connectedness in the posterior higher than the anterior at 15 weeks. By 10 months, cortices were thinner, with cortical area fraction and vascular density reduced, but only in the posterior cortex. This provided the first evidence of age-related effects on murine bone porosity due to the location of the intracortical vasculature. Targeting the vasculature to modulate bone porosity could provide an effective way to treat degenerative bone diseases, such as osteoporosis

Learning from leisure: Developing nature connectedness in outdoor education

The “greening” of outdoor education has received increasing attention from educators in Aotearoa-New Zealand and internationally. Given contemporary global concerns about the scale of environmental issues and the associated recognition that educating for sustainability is a matter of urgency, the continuing exploration of pedagogies promoting human connection to nature is arguably a central concern for outdoor educators. This paper contributes to professional dialogue about outdoor education pedagogies that may facilitate the development of students’ connectedness to, and care for, non-human nature. It draws from an interpretative research project that explored the meanings of nature-based leisure for eleven women aged 40 to 65 years. Findings from that research highlighted an important interplay between women’s conceptions of nature and their participation in leisure. The paper directs attention to three interconnected pedagogical principles that are teased from the women’s stories: repeated immersion in local nature environments, the decentring of traditional performance discourses, and critical reflection. These are presented as key considerations for outdoor education teachers and teacher educators in promoting nature connectedness and care. Recommendations are made for outdoor education researchers and teacher educators for future research directions

Commodity Dynamics: A Sparse Multi-class Approach

The correct understanding of commodity price dynamics can bring relevant improvements in terms of policy formulation both for developing and developed countries. Agricultural, metal and energy commodity prices might depend on each other: although we expect few important effects among the total number of possible ones, some price effects among different commodities might still be substantial. Moreover, the increasing integration of the world economy suggests that these effects should be comparable for different markets. This paper introduces a sparse estimator of the Multi-class Vector AutoRegressive model to detect common price effects between a large number of commodities, for different markets or investment portfolios. In a first application, we consider agricultural, metal and energy commodities for three different markets. We show a large prevalence of effects involving metal commodities in the Chinese and Indian markets, and the existence of asymmetric price effects. In a second application, we analyze commodity prices for five different investment portfolios, and highlight the existence of important effects from energy to agricultural commodities. The relevance of biofuels is hereby confirmed. Overall, we find stronger similarities in commodity price effects among portfolios than among markets

Intervention strategies for children and adolescent with disorders: from intrapsychic to transactional perspective

A large amount of studies and clinical evidence document the importance of infancy and early childhood influences on long term developmental trajectories toward mental health or psychopathology (Sameroff, 2000, 2010). Without healthy, productive adults no culture could continue to be successful. This concern is the main motivation for society to support child development research. Although the academic interests of contemporary developmental researchers range widely in cognitive and socialemotional domains, the political justification for supporting such studies is that they will lead to the understanding and ultimate prevention of behavioural problems that are costly to society. With these motivations and support, there have been major advances in our understanding of the intellectual, emotional, and social behaviour of children, adolescents and adults. This progress has forced conceptual reorientations from a unidirectionalunderstanding of development (e.g., parents affect children and not vice versa) toward a bidirectional conceptualization of development. Childrenare now assumed to affect and even select their environments as much as their environments affect their behaviour. Indeed, key among many of the most influential developmental theories in the past several decades is the assumption that children have bidirectional, or reciprocal, relationships with their environments (Bandura, 1977; Bronfenbrenner, 1979). To date, it is widely accepted that children’s healthy development is shaped by complex transactional processes among a variety of risk and protective factors, with cumulative risk factors increasing the prediction of emotional and behavioural problems (Anda et al., 2007; Rutter & Sroufe, 2000; Sameroff, 2000). Risk and protective factors include individual child characteristics such as genetic and constitutional propensities and cognitive strengths and vulnerabilities; parent characteristics such as mental health, education level, sense of efficacy, and resourcefulness; family factors such as quality of the parent-child relationship, emotional climate, and marital quality; community connectedness factors such as parental social support, social resources, and children’s peer relationships; and neighbourhood factors such as availability of resources, adequacy of housing, and levels of crime and violence (Sameroff & Fiese, 2000). The predictive value of these factors across many studies led to the development of transactional-bioecological models that attempt to conceptualize the relative contributions of proximal and distal risk and protective factors to children’s developmental outcome (Bronfenbrenner & Morris, 2006). In 1975, Sameroff and Chandler proposed the transactional model. This theoretical framework has become central to understanding the interplay between nature and nurture in explaining the development of positive and negative outcomes for children. The transactional model is a model of qualitative change. Sameroff asserted that the transactional model concerned qualitative rather than incremental change and that the underlying process was dialectical rather mechanistic in nature. The aim of this chapter is to explore this theoretical framework and its intervention strategies. In the first part, the transactional model will be described after a brief summary that will illustrate the transition from intrapsychic to transactional perspective. In the second part, intervention strategies for children and adolescent will be described. The attention of research on environmental risk and protective factors has fostered a more comprehensive understanding of what is necessary to improve the cognitive and social-emotional welfare of children and adolescents