Effects of dance therapy on balance, gait and neuro-psychological performances in patients with Parkinson's disease and postural instability

Postural Instability (PI) is a core feature of Parkinson’s Disease (PD) and a major cause of falls and disabilities. Impairment of executive functions has been called as an aggravating factor on motor performances. Dance therapy has been shown effective for improving gait and has been suggested as an alternative rehabilitative method. To evaluate gait performance, spatial-temporal (S-T) gait parameters and cognitive performances in a cohort of patients with PD and PI modifications in balance after a cycle of dance therapy

Behavioral analysis of conditions and treatments affecting movement and nociception

This thesis work includes three projects. First part deals with the investigation of novel D2 receptor ligands in Prepulse inhibition. The goal of this study is to establish a relationship between dopamine receptor antagonists and agonists and prepulse inhibition which can then serve as a working model for an in-vivo efficacy of novel dopamine D2 drugs. The second part of the thesis work deals with Niemann pick disease type C. Niemann pick disease type C is a progressive genetic disorder that is characterized by the lysosomal accumulation of lipids which causes neurodegeneration, dementia, ataxia, and death. NPC1nmf164 mutant mice (knockout) have a delayed acquisition of motor skills during development. The aim of our study was to identify cellular and molecular pathways involved in causing and progressing NPC in young patients from which effective therapeutic interventions can be designed and tested to prevent or delay the onset of the disease and prolong and improve the quality of life of young NPC patients. Finally, the last part of this thesis work includes studies on synergistic anithyperalgesic and antinociceptive effects of morphine and MP-III-024, a positive allosteric modulator at α2GABAA and α3GABAA receptors. The purpose of this study was to examine the interactive effects of the μ-opioid agonist morphine and the α2GABAA and α3GABAA receptor positive allosteric modulator MP-III-024 in preclinical models of mechanical hyperalgesia and thermal nociception

Affective Computing for Emotion Detection using Vision and Wearable Sensors

The research explores the opportunities, challenges, limitations, and presents advancements in computing that relates to, arises from, or deliberately influences emotions (Picard, 1997). The field is referred to as Affective Computing (AC) and is expected to play a major role in the engineering and development of computationally and cognitively intelligent systems, processors and applications in the future. Today the field of AC is bolstered by the emergence of multiple sources of affective data and is fuelled on by developments under various Internet of Things (IoTs) projects and the fusion potential of multiple sensory affective data streams. The core focus of this thesis involves investigation into whether the sensitivity and specificity (predictive performance) of AC, based on the fusion of multi-sensor data streams, is fit for purpose? Can such AC powered technologies and techniques truly deliver increasingly accurate emotion predictions of subjects in the real world? The thesis begins by presenting a number of research justifications and AC research questions that are used to formulate the original thesis hypothesis and thesis objectives. As part of the research conducted, a detailed state of the art investigations explored many aspects of AC from both a scientific and technological perspective. The complexity of AC as a multi-sensor, multi-modality, data fusion problem unfolded during the state of the art research and this ultimately led to novel thinking and origination in the form of the creation of an AC conceptualised architecture that will act as a practical and theoretical foundation for the engineering of future AC platforms and solutions. The AC conceptual architecture developed as a result of this research, was applied to the engineering of a series of software artifacts that were combined to create a prototypical AC multi-sensor platform known as the Emotion Fusion Server (EFS) to be used in the thesis hypothesis AC experimentation phases of the research. The thesis research used the EFS platform to conduct a detailed series of AC experiments to investigate if the fusion of multiple sensory sources of affective data from sensory devices can significantly increase the accuracy of emotion prediction by computationally intelligent means. The research involved conducting numerous controlled experiments along with the statistical analysis of the performance of sensors for the purposes of AC, the findings of which serve to assess the feasibility of AC in various domains and points to future directions for the AC field. The AC experiments data investigations conducted in relation to the thesis hypothesis used applied statistical methods and techniques, and the results, analytics and evaluations are presented throughout the two thesis research volumes. The thesis concludes by providing a detailed set of formal findings, conclusions and decisions in relation to the overarching research hypothesis on the sensitivity and specificity of the fusion of vision and wearables sensor modalities and offers foresights and guidance into the many problems, challenges and projections for the AC field into the future

Facial expression of pain: an evolutionary account.

This paper proposes that human expression of pain in the presence or absence of caregivers, and the detection of pain by observers, arises from evolved propensities. The function of pain is to demand attention and prioritise escape, recovery, and healing; where others can help achieve these goals, effective communication of pain is required. Evidence is reviewed of a distinct and specific facial expression of pain from infancy to old age, consistent across stimuli, and recognizable as pain by observers. Voluntary control over amplitude is incomplete, and observers can better detect pain that the individual attempts to suppress rather than amplify or simulate. In many clinical and experimental settings, the facial expression of pain is incorporated with verbal and nonverbal vocal activity, posture, and movement in an overall category of pain behaviour. This is assumed by clinicians to be under operant control of social contingencies such as sympathy, caregiving, and practical help; thus, strong facial expression is presumed to constitute and attempt to manipulate these contingencies by amplification of the normal expression. Operant formulations support skepticism about the presence or extent of pain, judgments of malingering, and sometimes the withholding of caregiving and help. To the extent that pain expression is influenced by environmental contingencies, however, "amplification" could equally plausibly constitute the release of suppression according to evolved contingent propensities that guide behaviour. Pain has been largely neglected in the evolutionary literature and the literature on expression of emotion, but an evolutionary account can generate improved assessment of pain and reactions to it

Clinical correlates of emotional dysregulation in bipolar disorder spectrum: a case-control study

openL'attuale studio si propone di studiare e quantificare le differenze tra i pazienti con BD, quelli con BPD, e controlli sani in (a) disregolazione emotiva utilizzando Difficoltà nelle scale di disregolazione delle emozioni (DERS), (b) impulsività valutata da Barratt Inibiion Scale (BIS-11), (c) abusi della prima infanzia utilizzando il Child Trauma Questionnaire (CTQ) e (d) funzionamento quotidiano con il World Health Organization Disability Assessment Schedule (WHODAS.2). Questo studio si propone di aiutare i medici nel compito impegnativo di distinguere tra i pazienti con BD e BPD, contribuendo così al perfezionamento della diagnosi precoce di questi disturbi.The current study aims to investigate and quantify differences between patients with BD, those with BPD, and healthy controls in (a) emotional dysregulation using Difficulties in emotion dysregulation scales (DERS), (b) impulsivity assessed by Barratt Inhibition Scale (BIS-11), (c) early childhood abuses using the Child Trauma Questionnaire (CTQ) and (d) daily functioning with the World Health Organization Disability Assessment Schedule (WHODAS.2). This study aims to assist clinicians in the challenging task of distinguishing between patients with BD and BPD, thereby contributing to the refinement of the earlier diagnosis of these disorders

The utility of the auditory brainstem response in children with atypical saccadic eye movements

Full version unavailable due to 3rd party copyright restrictionsLesions in the brainstem result in widespread damage to a number of sensorimotor systems including oculomotor and auditory neural circuits. Although these systems are spatially separate and highly specialised, they are also co-located. This thesis, investigates whether lesions in the oculomotor system will also cause co-morbid dysfunction in the auditory pathways. Specifically, we investigated the usefulness of the Auditory Brainstem Response (ABR) in two oculomotor conditions: slow saccades in Gaucher disease (GD) and opsoclonus in Dancing Eye Syndrome (DES). We present four empirical studies. In our first study we systematically investigated the ABR in GD. We found that multimodal testing can better delineate underlying neurological deficits in neuronopathic GD (nGD) and distinguish between phenotypes. In the second study we examined the ABR's utility as a longitudinal, objective marker of disease burden and in a randomised clinical control trial. ABRs continued to deteriorate regardless of treatment. In our third study we assessed audiological function in DES. We found that at least 43% of DES patients have hyperacusis. We also found subtle abnormalities in the auditory brainstem, as shown by the ABR. Our final study explored the onset-offset response in the ABR and assessed its utility as a clinical marker. Overall, this thesis provides new evidence that auditory pathways are also affected in diseases which are traditionally assumed to be ‘oculomotor’ in nature. We believe that there is sufficient evidence to warrant the inclusion of audiological testing, such as the ABR, as part of the standard assessment of newly diagnosed GD patients and that they undergo these tests prior to commencing treatment. These tests may also have a wider application as longitudinal outcome measures for use in clinical trials or as markers of neurological burden in GD and we believe may be useful in other metabolic diseases; we found that current therapies for GD have low efficacy. Understanding the underlying neurological deficits in these debilitating illnesses can only help to improve treatments and the long-term outlook for these patients