243,416 research outputs found
Computational study of radicals derived from hydroxyurea and its methylated analogues.
Structural and electronic properties and chemical fate of free radicals generated from hydroxyurea (HU) and its methylated analogues N-methylhydroxyurea (NMHU) and O-methylhydroxyurea (OMHU) are of utmost importance for their biological and pharmacological effects. In this work the cis/trans conformational processes, tautomerizations, and intramolecular hydrogen and methyl migrations in hydroxyurea-derived radicals have been considered. Potential energy profiles for these reactions have been calculated using two DFT functionals (BP86 and B3LYP) and two composite models (G3(MP2)RAD and G3B3). Solvation effects have been included both implicitly (CPCM) and explicitly. It has been shown that calculated energy barriers for free radical rearrangements are significantly reduced when a single water molecule is included in calculations. In the case of HU-derived open-shell species, a number of oxygen-, nitrogen-, and carbon-centered radicals have been located, but only the O-centered radicals (e1 and z1) fit to experimental isomeric hyperfine coupling constants (hfccs) from EPR spectra. The reduction of NMHU and OMHU produces O-centered and N-centered radicals, respectively, with the former being more stable by ca. 60 kJ molâ1. The NMHU-derived radical e4 undergoes rearrangements, which can result in formation of several conceivable products. The calculated hfccs have been successfully used to interpret the experimental EPR spectra of the most probable rearranged product 10. Reduction potentials of hydroxyureas, radical stabilization energy (RSE) and bond disocciation energy (BDE) values have been calculated to compare stabilities and reactivities of different subclasses of free radicals. It has been concluded, in agreement with experiment, that reductions of biologically relevant tyrosyl radicals by HU and NMHU are thermochemically favorable processes, and that the order of reactivity of hydroxyureas follows the experimentally observed trend NMHU > HU > OMHU
Enterprise Experience into the Integration of Human-Centered Design and Kanban
he integration of Human-Centered Design (HCD) and Agile Software Development (ASD) promises the
development of competitive products comprising a good User Experience (UX). This study has investigated
the integration of HCD and Kanban with the aim to gain industrial experiences in a real world context. A
case study showed that requirements flow into the development process in a structured manner by adding a
design board. To this end, the transparency concerning recurring requirements increased. We contribute to
the body of knowledge of software development by providing practical insights into Human-Centered Agile
Development (HCAD). On one hand, it is shown that the integration of HCD and Kanban leads to a product
with a good UX and makes the development process more human-centered. On the other hand, we conclude
that a cross-functional collaboration speeds up product development.Ministerio de EconomĂa y Competitividad TIN2013-46928-C3-3-RMinisterio de EconomĂa y Competitividad TIN2015-71938-RED
Towards a kansei-based user modeling methodology for eco-design
We propose here to highlight the benefits of building a framework linking Kansei Design (KD), User Centered Design (UCD) and Eco-design, as the correlation between these fields is barely explored in research at the current time. Therefore, we believe Kansei Design could serve the goal of achieving more sustainable products by setting up an accurate understanding of the user in terms of ecological awareness, and consequently enhancing performance in the Eco-design process. In the same way, we will consider the means-end chain approach inspired from marketing research, as it is useful for identifying ecological values, mapping associated functions and defining suitable design solutions. Information gathered will serve as entry data for conducting scenario-based design, and supporting the development of an Eco-friendly User Centered Design methodology (EcoUCD).ANR-ECOUS
Il turista della societĂ post-moderna: la cultura del new life tourism Spazio, luogo e non luogo Turismo, paesaggio, spazi pubblici e rigenerazione urbana Tematismi e tematizzazione. Itinerari culturali e strade turistiche per una ricomposizione spaziale.
I materiali sono composti dalle prime tre presentazioni, i contributi dedicati al tema dell'autenticitĂ , della diversa interpretazione di spazio, luogo e non luogo e degli itinerari culturali. Completano questo primo deposito di materiale didattico due approfondimenti sulla Consumer Culture Theory e Service Dominat Logic
Transdisciplinarity seen through Information, Communication, Computation, (Inter-)Action and Cognition
Similar to oil that acted as a basic raw material and key driving force of
industrial society, information acts as a raw material and principal mover of
knowledge society in the knowledge production, propagation and application. New
developments in information processing and information communication
technologies allow increasingly complex and accurate descriptions,
representations and models, which are often multi-parameter, multi-perspective,
multi-level and multidimensional. This leads to the necessity of collaborative
work between different domains with corresponding specialist competences,
sciences and research traditions. We present several major transdisciplinary
unification projects for information and knowledge, which proceed on the
descriptive, logical and the level of generative mechanisms. Parallel process
of boundary crossing and transdisciplinary activity is going on in the applied
domains. Technological artifacts are becoming increasingly complex and their
design is strongly user-centered, which brings in not only the function and
various technological qualities but also other aspects including esthetic, user
experience, ethics and sustainability with social and environmental dimensions.
When integrating knowledge from a variety of fields, with contributions from
different groups of stakeholders, numerous challenges are met in establishing
common view and common course of action. In this context, information is our
environment, and informational ecology determines both epistemology and spaces
for action. We present some insights into the current state of the art of
transdisciplinary theory and practice of information studies and informatics.
We depict different facets of transdisciplinarity as we see it from our
different research fields that include information studies, computability,
human-computer interaction, multi-operating-systems environments and
philosophy.Comment: Chapter in a forthcoming book: Information Studies and the Quest for
Transdisciplinarity - Forthcoming book in World Scientific. Mark Burgin and
Wolfgang Hofkirchner, Editor
Evaluating Content-centric vs User-centric Ad Affect Recognition
Despite the fact that advertisements (ads) often include strongly emotional
content, very little work has been devoted to affect recognition (AR) from ads.
This work explicitly compares content-centric and user-centric ad AR
methodologies, and evaluates the impact of enhanced AR on computational
advertising via a user study. Specifically, we (1) compile an affective ad
dataset capable of evoking coherent emotions across users; (2) explore the
efficacy of content-centric convolutional neural network (CNN) features for
encoding emotions, and show that CNN features outperform low-level emotion
descriptors; (3) examine user-centered ad AR by analyzing Electroencephalogram
(EEG) responses acquired from eleven viewers, and find that EEG signals encode
emotional information better than content descriptors; (4) investigate the
relationship between objective AR and subjective viewer experience while
watching an ad-embedded online video stream based on a study involving 12
users. To our knowledge, this is the first work to (a) expressly compare user
vs content-centered AR for ads, and (b) study the relationship between modeling
of ad emotions and its impact on a real-life advertising application.Comment: Accepted at the ACM International Conference on Multimodal Interation
(ICMI) 201
Improving situation awareness of a single human operator interacting with multiple unmanned vehicles: first results
In the context of the supervision of one or several unmanned vehicles by a human operator, the design of an adapted user interface is a major challenge. Therefore, in the context of an existing experimental set up composed of a ground station and heterogeneous unmanned ground and air vehicles we aim at redesigning the human-robot interactions to improve the operator's situation awareness. We base our new design on a classical user centered approach
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