22 research outputs found

    SCANMOT: searching for similar sequences using a simultaneous scan of multiple sequence motifs

    Get PDF
    Establishment of similarities between proteins is very important for the study of the relationship between sequence, structure and function and for the analysis of evolutionary relationships. Motif-based search methods play a crucial role in establishing the connections between proteins that are particularly useful for distant relationships. This paper reports SCANMOT, a web-based server that searches for similarities between proteins by simultaneous matching of multiple motifs. SCANMOT searches for similar sequences in entire sequence databases using multiple conserved regions and utilizes inter-motif spacing as restraints. The SCANMOT server is available via

    Understanding Mammalian Genetic Systems: The Challenge of Phenotyping in the Mouse

    Get PDF
    Understanding mammalian genetic systems is predicated on the determination of the relationship between genetic variation and phenotype. Several international programmes are under way to deliver mutations in every gene in the mouse genome. The challenge for mouse geneticists is to develop approaches that will provide comprehensive phenotype datasets for these mouse mutant libraries. Several factors are critical to success in this endeavour. It will be important to catalogue assay and environment and where possible to adopt standardised procedures for phenotyping tests along with common environmental conditions to ensure comparable datasets of phenotypes. Moreover, the scale of the task underlines the need to invest in technological development improving both the speed and cost of phenotyping platforms. In addition, it will be necessary to develop new informatics standards that capture the phenotype assay as well as other factors, genetic and environmental, that impinge upon phenotype outcome

    Genetic mapping of EST-SSR, SSR and InDel to improve saturation of genomic regions in a previously developed sunflower map

    Get PDF
    In order to saturate a sunflower genetic map and facilitate marker-assisted selection (MAS) breeding for stress response, it is necessary to enhance map saturation with molecular markers localized in linkage groups associated to genomic regions involved in these traits. This work describes the identification and characterization of 1,134 simple sequence repeat (SSR) containing expressed sequence tags (EST) from unigenes available databases. Twelve of these functional markers as well as 41 public SSR markers were successfully localized in linkage groups, thus contributing to the saturation of specific regions on a reference genetic-linkage-map derived from recombinant inbred lines (RIL) mapping population from the cross between PAC2 x RHA266 lines. The enriched map includes 547 markers (231 SSR, 9 EST-SSR, 3 insertions/deletions (InDel) and 304 amplified fragment length polymorphisms (AFLP) distributed in 17 linkage groups (LG), spanning genetic size to 1,942.3 cM and improving its mean density to 3.6 cM per locus. As consequence, no gaps longer than 13.2 cM remain uncovered throughout the entire map, which increases the feasibility of detecting genes or traits of agronomic importance in sunflower

    Fusion features ensembling models using Siamese convolutional neural network for kinship verification

    Get PDF
    Family is one of the most important entities in the community. Mining the genetic information through facial images is increasingly being utilized in wide range of real-world applications to facilitate family members tracing and kinship analysis to become remarkably easy, inexpensive, and fast as compared to the procedure of profiling Deoxyribonucleic acid (DNA). However, the opportunities of building reliable models for kinship recognition are still suffering from the insufficient determination of the familial features, unstable reference cues of kinship, and the genetic influence factors of family features. This research proposes enhanced methods for extracting and selecting the effective familial features that could provide evidences of kinship leading to improve the kinship verification accuracy through visual facial images. First, the Convolutional Neural Network based on Optimized Local Raw Pixels Similarity Representation (OLRPSR) method is developed to improve the accuracy performance by generating a new matrix representation in order to remove irrelevant information. Second, the Siamese Convolutional Neural Network and Fusion of the Best Overlapping Blocks (SCNN-FBOB) is proposed to track and identify the most informative kinship clues features in order to achieve higher accuracy. Third, the Siamese Convolutional Neural Network and Ensembling Models Based on Selecting Best Combination (SCNN-EMSBC) is introduced to overcome the weak performance of the individual image and classifier. To evaluate the performance of the proposed methods, series of experiments are conducted using two popular benchmarking kinship databases; the KinFaceW-I and KinFaceW-II which then are benchmarked against the state-of-art algorithms found in the literature. It is indicated that SCNN-EMSBC method achieves promising results with the average accuracy of 92.42% and 94.80% on KinFaceW-I and KinFaceW-II, respectively. These results significantly improve the kinship verification performance and has outperformed the state-of-art algorithms for visual image-based kinship verification

    Ontology and Information Systems

    Get PDF
    In a development that has still been hardly noticed by philosophers, a conception of ontology has been advanced in recent years in a series of extra-philosophical disciplines as researchers in linguistics, psychology, geography and anthropology have sought to elicit the ontological commitments (‘ontologies’, in the plural) of different cultures or disciplines. Exploiting the terminology of Quine, researchers in psychology and anthropology have sought to establish what individual human subjects, or entire human cultures, are committed to, ontologically, in their everyday cognition, in much the same way in which philosophers of science have attempted to elicit the ontological commitments of the natural sciences. Thus they have engaged in inquiries designed to establish how folk ontologies (or folk biologies, folk theories of physics, folk psychologies, and so on) develop through infancy and childhood, or to establish the degree to which given elements of folk ontologies reflect universal features of the human cognitive system. In a parallel development, researchers in biomedicine developed what they called 'ontologies' as controlled vocabularies to ensure interoperability of the way in which, for example, genomic data is described in different biological disciplines. We describe in what follows some of the relations between these efforts and the more traditional concerns of philosophers

    Bioinformatics Applications Based On Machine Learning

    Get PDF
    The great advances in information technology (IT) have implications for many sectors, such as bioinformatics, and has considerably increased their possibilities. This book presents a collection of 11 original research papers, all of them related to the application of IT-related techniques within the bioinformatics sector: from new applications created from the adaptation and application of existing techniques to the creation of new methodologies to solve existing problems

    Bulletin of scientific and art research : annual report for 2018

    Get PDF
    The SASA Fund allotted the available resources for the following purposes: scientific and art research projects, scientific publications, international scientific cooperation, the organization of scientific meetings, participation of SASA members and their associates in scientific meetings in the country and abroad, acquisition of scientific literature and other purposes under the SASA Scientific and Art Research Programme. In 2018, the SASA Scientific and Art Research Programme contained 28 projects in the fields of mathematics, physics and earth sciences, 20 in the fields of chemical and biological sciences; 13 in the fields of technical and technological sciences; 28 in the field of medical sciences, 12 in the fields of language and literature; 16 in the field of social sciences; 25 in the field of historical sciences, and 8 in the fields of visual arts and music. During the year, the SASA published 52 editions, including 13 journal issues, 19 collections of papers, 13 catalogues, five monographs, two jubilee bibliographies and Volume XX of the SASA Dictionary, while 1,162 authors published 540 papers. The first-ever commercial Catalogue of the SASA Editions: 2016–2017–2018 (Katalog izdanja SANU: 2016–2017–2018) was prepared and published. In addition, 22 manuscripts were technically processed and prepared for publication; the make-up and cover design of six publications were finished. The SASA maintained regular contact with the National Library of Serbia concerning the preparation of a Cataloguing in Publication (CIP) record for all SASA editions. Fourteen manuscripts in the Serbian language underwent orthographic editing and 15 publications underwent proofreading, thus being prepared for publishing. The Serbian Academy of Sciences and Arts hosted the meeting of the COST (European Cooperation in Science and Technology) Action titled “Maximizing Impact of Research in Neurodevelopmental Disorders”. It was the first formal meeting of the COST Action which has so far been joined by about 50 researchers from 20 European countries. During 2018, two lecture cycles were held: “The Fascinating World of Nanoscience and Nanotechnology” (Fascinantni svet nanonauke i nanotehnologije) and “Geohazard in 21st Century Serbia: Knowledge Is the Best Bulwark Against the Elements” (Geohazard u Srbiji u 21. veku – Znanje je najbolji bedem protiv stihije), totalling 11 lectures. In 2018, at the proposal of the SASA Departments and SASA Executive Board, 12 lectures were held. Pursuant to the Decision of the Professional Council of the SASA Library, the SASA Library Day will be celebrated on 14 June. The SASA Library started working on this day, when it received the first books from Dimitrije Tirol. Its first librarian was Konstantin Bogdanović. The SASA Library Day was marked by the celebration honouring Aleksa Šantić. In 2018, the SASA Library organized 17 forums. It presented 18 books and 13 collections of papers by SASA members, SASA editions, as well as the research institutes and centres founded by the SASA. It staged 12 chamber exhibitions. Pursuant to the Decision of the Professional Council of the SASA Library, the SASA Library Day will be celebrated on 14 June. The SASA Library started working on this day, when it received the first books from Dimitrije Tirol. Its first librarian was Konstantin Bogdanović. The SASA Library Day was marked by the celebration honouring Aleksa Šantić. In 2018, the SASA Library organized 17 forums. It presented 18 books and 13 collections of papers by SASA members, SASA editions, as well as the research institutes and centres founded by the SASA. It staged 12 chamber exhibitions. The SASA Library also published the jubilee Bibliography of Academician Nikola Tasić’s Works, authored by Milena Obradović, and the sixth issue of the SASA Library Forum Almanac (Godišnjak “Tribina Biblioteke SANU”). The 293-page issue of the Almanac contains the presentations given at the forums in 2017. In 2018, the SASA Gallery staged eight thematic exhibitions on its premises: “Stojan Novaković and His Era” (Stojan Novaković i njegovo doba), “So, you are Uroš Predić?“ (Dakle, vi ste taj Uroš Predić), “35 Years of Petnica” (35 godina Petnice), “Mihailo Petrović Alas, the Founding Father of the Serbian School of Mathematics” (Mihailo Petrović Alas, rodonačelnik srpske matematičke škole), “Nedeljko Gvozdenović. On a Quest for Absolute Painting” (Nedeljko Gvozdenović. U potrazi za apsolutnim slikarstvom), “Roman Limes and Cities in Serbia” (Rimski limes i gradovi u Srbiji), 57th October Salon. “The Marvellous Cacophony” (57. Oktobarski salon. Čudo kakofonije), “Marko Čelebonović (1902-1986)”, Retrospective Exhibition (Marko Čelebonović /1902-1986/. Retrospektivna izložba). All exhibitions were accompanied by catalogues, lectures and expert guidance. Six catalogues were printed and one was prepared for printing. The exhibitions staged outside the SASA Gallery included: “SASA Art Collection – Academician Artists” (Umetnička zbirka SANU – likovni umetnici akademici), which toured Požarevac, Leskovac and Svilajnac, and “Olga Jevrić Exhibition – Sculptures” (Izložba Olga Jevrić – skulpture) in Užice. Seven new exhibitions were also prepared. In 2018, the Gallery of the Serbian Academy of Sciences and Arts organized 74 concerts within the relevant cycles. The concert-related activity of the SASA Gallery is headed by Academician Ivan Jevtić. During the year, the SASA Gallery of Science and Technology staged 15 exhibitions, supported by rich accompanying programmes. The names of these exhibitions were “Roma Tribulation in World War I” (Stradanje Roma u Prvom svetskom ratu); “Ivan Djaja. The Belgrade School of Physiology – from the Sorbonne to Belgrade” (Ivan Djaja. Beogradska škola fiziologije – od Sorbone do Beograda); “Brain Awareness Week 2018 – All Sides of Consciousness” (Nedelja svesti o mozgu – Sve strane svesti); “Traditional Architectural Heritage in the Area of the Stara Planina” (Tradicionalno arhitektonsko nasledje u regionu Stare planine); “The History of Toxicology” (Istorija toksikologije); THE POWER OF HERBS – The 70th Anniversary of the Institute for Medicinal Herb Research “Dr Josif Pančić” (MOĆ BILJA – povodom 70 godina rada Instituta za proučavanje lekovitog bilja “Dr Josif Pančić”); “This too Is Serbia, ’68 in Student” (I ovo je Srbija, ’68. u Studentu); “Archaeological Forensics – 20 Years of New Archaeological Invesigations of Vinča” (Forenzika drevnosti – 20 godina novih arheoloških istraživanja lokaliteta Vinča); “Serbian Lexicography from Vuk to the Present Day” (Srpska leksikografija od Vuka do danas); “Jovan Stejić, First Serbian Doctorof Medicine in Restored Serbia” (Jovan Stejić, prvi Srbin doktor medicine u obnovljenoj Srbiji); The Salonika Front, 1916-1918 (Solunski front 1916- 1918); World War One in Miniature (Prvi svetski rat u minijaturi), and ON ARCHITECTURE 2018 (O ARHITEKTURI 2018). The exhibitions were supported by the relevant catalogues (5) and rich accompanying programmes. In 2018, the SASA Archives enriched its holdings by numerous gifts. It finished processing Academician Vasa Čubrilović’s manuscript legacy and Patriarch German Andjelić’s legacy. The processing of Dragoljub Jovanović’s legacy will be finished during the first few months of 2019. The work on organizing the collection held in the Cabinet for Medals was carried out. The electronic Incoming Inventory of the Cabinet was prepared. All decorations were sorted out and placed into archival boxes in order to ensure better protection and facilitate handling. The Central Institute for Conservation conserved 169 decorations. More than 800 decorations were photographed and cataloguing was done in accordance with all museological processing rules. The website and digital presentation were created, and the biographies of all donors were written. The result of this work is the permanent exhibition of the Cabinet for Medals, which was opened on the Day of the Academy on 19 November 2018. During the past year, the SASA archivists catered to 223 researchers. The reference library of the SASA Archives was enriched by 70 new books.Ima izdanje na drugom jeziku: Билтен Фонда САНУ за истраживања у науци и уметности = ISSN 2466-428
    corecore