Routes for breaching and protecting genetic privacy

We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases. However, one growing concern is the ability to protect the genetic privacy of the data originators. Here, we technically map threats to genetic privacy and discuss potential mitigation strategies for privacy-preserving dissemination of genetic data.Comment: Draft for comment

Data Privacy Preservation in Collaborative Filtering Based Recommender Systems

This dissertation studies data privacy preservation in collaborative filtering based recommender systems and proposes several collaborative filtering models that aim at preserving user privacy from different perspectives. The empirical study on multiple classical recommendation algorithms presents the basic idea of the models and explores their performance on real world datasets. The algorithms that are investigated in this study include a popularity based model, an item similarity based model, a singular value decomposition based model, and a bipartite graph model. Top-N recommendations are evaluated to examine the prediction accuracy. It is apparent that with more customers\u27 preference data, recommender systems can better profile customers\u27 shopping patterns which in turn produces product recommendations with higher accuracy. The precautions should be taken to address the privacy issues that arise during data sharing between two vendors. Study shows that matrix factorization techniques are ideal choices for data privacy preservation by their nature. In this dissertation, singular value decomposition (SVD) and nonnegative matrix factorization (NMF) are adopted as the fundamental techniques for collaborative filtering to make privacy-preserving recommendations. The proposed SVD based model utilizes missing value imputation, randomization technique, and the truncated SVD to perturb the raw rating data. The NMF based models, namely iAux-NMF and iCluster-NMF, take into account the auxiliary information of users and items to help missing value imputation and privacy preservation. Additionally, these models support efficient incremental data update as well. A good number of online vendors allow people to leave their feedback on products. It is considered as users\u27 public preferences. However, due to the connections between users\u27 public and private preferences, if a recommender system fails to distinguish real customers from attackers, the private preferences of real customers can be exposed. This dissertation addresses an attack model in which an attacker holds real customers\u27 partial ratings and tries to obtain their private preferences by cheating recommender systems. To resolve this problem, trustworthiness information is incorporated into NMF based collaborative filtering techniques to detect the attackers and make reasonably different recommendations to the normal users and the attackers. By doing so, users\u27 private preferences can be effectively protected

Synthetic Observational Health Data with GANs: from slow adoption to a boom in medical research and ultimately digital twins?

After being collected for patient care, Observational Health Data (OHD) can further benefit patient well-being by sustaining the development of health informatics and medical research. Vast potential is unexploited because of the fiercely private nature of patient-related data and regulations to protect it. Generative Adversarial Networks (GANs) have recently emerged as a groundbreaking way to learn generative models that produce realistic synthetic data. They have revolutionized practices in multiple domains such as self-driving cars, fraud detection, digital twin simulations in industrial sectors, and medical imaging. The digital twin concept could readily apply to modelling and quantifying disease progression. In addition, GANs posses many capabilities relevant to common problems in healthcare: lack of data, class imbalance, rare diseases, and preserving privacy. Unlocking open access to privacy-preserving OHD could be transformative for scientific research. In the midst of COVID-19, the healthcare system is facing unprecedented challenges, many of which of are data related for the reasons stated above. Considering these facts, publications concerning GAN applied to OHD seemed to be severely lacking. To uncover the reasons for this slow adoption, we broadly reviewed the published literature on the subject. Our findings show that the properties of OHD were initially challenging for the existing GAN algorithms (unlike medical imaging, for which state-of-the-art model were directly transferable) and the evaluation synthetic data lacked clear metrics. We find more publications on the subject than expected, starting slowly in 2017, and since then at an increasing rate. The difficulties of OHD remain, and we discuss issues relating to evaluation, consistency, benchmarking, data modelling, and reproducibility.Comment: 31 pages (10 in previous version), not including references and glossary, 51 in total. Inclusion of a large number of recent publications and expansion of the discussion accordingl

Synthetic sequence generator for recommender systems - memory biased random walk on sequence multilayer network

Personalized recommender systems rely on each user's personal usage data in the system, in order to assist in decision making. However, privacy policies protecting users' rights prevent these highly personal data from being publicly available to a wider researcher audience. In this work, we propose a memory biased random walk model on multilayer sequence network, as a generator of synthetic sequential data for recommender systems. We demonstrate the applicability of the synthetic data in training recommender system models for cases when privacy policies restrict clickstream publishing.Comment: The new updated version of the pape