7,134 research outputs found
You can't always sketch what you want: Understanding Sensemaking in Visual Query Systems
Visual query systems (VQSs) empower users to interactively search for line
charts with desired visual patterns, typically specified using intuitive
sketch-based interfaces. Despite decades of past work on VQSs, these efforts
have not translated to adoption in practice, possibly because VQSs are largely
evaluated in unrealistic lab-based settings. To remedy this gap in adoption, we
collaborated with experts from three diverse domains---astronomy, genetics, and
material science---via a year-long user-centered design process to develop a
VQS that supports their workflow and analytical needs, and evaluate how VQSs
can be used in practice. Our study results reveal that ad-hoc sketch-only
querying is not as commonly used as prior work suggests, since analysts are
often unable to precisely express their patterns of interest. In addition, we
characterize three essential sensemaking processes supported by our enhanced
VQS. We discover that participants employ all three processes, but in different
proportions, depending on the analytical needs in each domain. Our findings
suggest that all three sensemaking processes must be integrated in order to
make future VQSs useful for a wide range of analytical inquiries.Comment: Accepted for presentation at IEEE VAST 2019, to be held October 20-25
in Vancouver, Canada. Paper will also be published in a special issue of IEEE
Transactions on Visualization and Computer Graphics (TVCG) IEEE VIS
(InfoVis/VAST/SciVis) 2019 ACM 2012 CCS - Human-centered computing,
Visualization, Visualization design and evaluation method
A virtual imaging platform for multi-modality medical image simulation.
International audienceThis paper presents the Virtual Imaging Platform (VIP), a platform accessible at http://vip.creatis.insa-lyon.fr to facilitate the sharing of object models and medical image simulators, and to provide access to distributed computing and storage resources. A complete overview is presented, describing the ontologies designed to share models in a common repository, the workflow template used to integrate simulators, and the tools and strategies used to exploit computing and storage resources. Simulation results obtained in four image modalities and with different models show that VIP is versatile and robust enough to support large simulations. The platform currently has 200 registered users who consumed 33 years of CPU time in 2011
Community standards for open cell migration data
Cell migration research has become a high-content field. However, the quantitative information encapsulated in these complex and high-dimensional datasets is not fully exploited owing to the diversity of experimental protocols and non-standardized output formats. In addition, typically the datasets are not open for reuse. Making the data open and Findable, Accessible, Interoperable, and Reusable (FAIR) will enable meta-analysis, data integration, and data mining. Standardized data formats and controlled vocabularies are essential for building a suitable infrastructure for that purpose but are not available in the cell migration domain. We here present standardization efforts by the Cell Migration Standardisation Organisation (CMSO), an open community-driven organization to facilitate the development of standards for cell migration data. This work will foster the development of improved algorithms and tools and enable secondary analysis of public datasets, ultimately unlocking new knowledge of the complex biological process of cell migration
nmrML, mzML data exchange formats and associated terminologies for instrument raw data, with reference implementation guidelines and validation rules - D8.3
This deliverable reports on the creation of a new open NMR data standard and the update of another one for Mass Spectrometry to support the exchange and deposition of raw instrument NMR and MS data used for Metabolomics applications.
Furthermore, the report details how these formal specifications are now supported by software tools and implementations, facilitating format uptake and use by academics and manufacturers alike, linking to documentation and user guides
Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine
Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study. Furthermore, the demand for logistics, instrumentations, and computational resources for metabolic phenotyping studies has far exceeded our expectations. In this conceptual review, we will cover inclusive barriers of a metabolomics-based clinical study and suggest potential solutions in the hope of enhancing study robustness, usability, and transferability. The importance of quality assurance and quality control procedures is discussed, followed by a practical rule containing five phases, including two additional "pre-pre-" and "post-post-" analytical steps. Besides, we will elucidate the potential involvement of machine learning and demonstrate that the need for automated data mining algorithms to improve the quality of future research is undeniable. Consequently, we propose a comprehensive metabolomics framework, along with an appropriate checklist refined from current guidelines and our previously published assessment, in the attempt to accurately translate achievements in metabolomics into clinical and epidemiological research. Furthermore, the integration of multifaceted multi-omics approaches with metabolomics as the pillar member is in urgent need. When combining with other social or nutritional factors, we can gather complete omics profiles for a particular disease. Our discussion reflects the current obstacles and potential solutions toward the progressing trend of utilizing metabolomics in clinical research to create the next-generation healthcare system.11Ysciescopu
MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI
Many medical imaging techniques utilize fitting approaches for quantitative
parameter estimation and analysis. Common examples are pharmacokinetic modeling
in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and
Z-spectra analysis in chemical exchange saturation transfer MRI. Most available
software tools are limited to a special purpose and do not allow for own
developments and extensions. Furthermore, they are mostly designed as
stand-alone solutions using external frameworks and thus cannot be easily
incorporated natively in the analysis workflow. We present a framework for
medical image fitting tasks that is included in MITK, following a rigorous
open-source, well-integrated and operating system independent policy. Software
engineering-wise, the local models, the fitting infrastructure and the results
representation are abstracted and thus can be easily adapted to any model
fitting task on image data, independent of image modality or model. Several
ready-to-use libraries for model fitting and use-cases, including fit
evaluation and visualization, were implemented. Their embedding into MITK
allows for easy data loading, pre- and post-processing and thus a natural
inclusion of model fitting into an overarching workflow. As an example, we
present a comprehensive set of plug-ins for the analysis of DCE MRI data, which
we validated on existing and novel digital phantoms, yielding competitive
deviations between fit and ground truth. Providing a very flexible environment,
our software mainly addresses developers of medical imaging software that
includes model fitting algorithms and tools. Additionally, the framework is of
high interest to users in the domain of perfusion MRI, as it offers
feature-rich, freely available, validated tools to perform pharmacokinetic
analysis on DCE MRI data, with both interactive and automatized batch
processing workflows.Comment: 31 pages, 11 figures URL: http://mitk.org/wiki/MITK-ModelFi
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