Enhancement of the Sensory Capabilities of Mobile Robots through Artificial Olfaction

La presente tesis abarca varios aspectos del olfato artificial u olfato robótico, la capacidad de percibir información sobre la composición del aire que rodea a un sistema automático. En primer lugar, se desarrolla una nariz electrónica, un instrumento que combina sensores de gas de bajas prestaciones con un algoritmo de clasificación para medir e identificar gases. Aunque esta tecnología ya existía previamente, se aplica un nuevo enfoque que busca reducir las dimensiones y consumo para poder instalarlas en robots móviles, a la vez que se aumenta el número de gases detectables mediante un diseño modular. Posteriormente, se estudia la estrategia óptima para encontrar fugas de gas con un robot equipado con este tipo de narices electrónicas. Para ello se llevan a cabos varios experimentos basados en teleoperación para entender como afectan los sensores del robot al éxito de la tarea, de lo cual se deriva finalmente un algoritmo para generar con robots autónomos mapas de gas de un entorno dado, el cual se inspira en el comportamiento humano, a saber, maximizar la información conocida sobre el entorno. La principal virtud de este método, además de realizar una exploración óptima del entorno, es su capacidad para funcionar en entornos muy complejos y sujetos a corrientes de vientos mediante un nuevo método que también se presenta en esta tesis. Finalmente, se presentan dos casos de aplicación en los que se identifica de forma automática con una nariz electrónica la calidad subjetiva del aire en entornos urbanos

Error minimising gradients for improving cerebellar model articulation controller performance

In motion control applications where the desired trajectory velocity exceeds an actuator’s maximum velocity limitations, large position errors will occur between the desired and actual trajectory responses. In these situations standard control approaches cannot predict the output saturation of the actuator and thus the associated error summation cannot be minimised.An adaptive feedforward control solution such as the Cerebellar Model Articulation Controller (CMAC) is able to provide an inherent level of prediction for these situations, moving the system output in the direction of the excessive desired velocity before actuator saturation occurs. However the pre-empting level of a CMAC is not adaptive, and thus the optimal point in time to start moving the system output in the direction of the excessive desired velocity remains unsolved. While the CMAC can adaptively minimise an actuator’s position error, the minimisation of the summation of error over time created by the divergence of the desired and actual trajectory responses requires an additional adaptive level of control.This thesis presents an improved method of training CMACs to minimise the summation of error over time created when the desired trajectory velocity exceeds the actuator’s maximum velocity limitations. This improved method called the Error Minimising Gradient Controller (EMGC) is able to adaptively modify a CMAC’s training signal so that the CMAC will start to move the output of the system in the direction of the excessive desired velocity with an optimised pre-empting level.The EMGC was originally created to minimise the loss of linguistic information conveyed through an actuated series of concatenated hand sign gestures reproducing deafblind sign language. The EMGC concept however is able to be implemented on any system where the error summation associated with excessive desired velocities needs to be minimised, with the EMGC producing an improved output approximation over using a CMAC alone.In this thesis, the EMGC was tested and benchmarked against a feedforward / feedback combined controller using a CMAC and PID controller. The EMGC was tested on an air-muscle actuator for a variety of situations comprising of a position discontinuity in a continuous desired trajectory. Tested situations included various discontinuity magnitudes together with varying approach and departure gradient profiles.Testing demonstrated that the addition of an EMGC can reduce a situation’s error summation magnitude if the base CMAC controller has not already provided a prior enough pre-empting output in the direction of the situation. The addition of an EMGC to a CMAC produces an improved approximation of reproduced motion trajectories, not only minimising position error for a single sampling instance, but also over time for periodic signals

Design of a pneumatic soft robotic actuator using model-based optimization

In this thesis, the design and optimization process of a novel soft intelligent modular pad (IntelliPad) for the purpose of pressure injury prevention is presented. The structure of the IntelliPad consists of multiple individual multi-chamber soft pneumatic-driven actuators that use pressurized air and vacuum. Each actuator is able to provide both vertical and horizontal motions that can be controlled independently. An analytical modeling approach using multiple cantilever beams and virtual springs connected in a closed formed structure was developed to analyze the mechanical performance of the actuator. The analytical approach was validated by a finite element analysis. For optimizing the actuator\u27s mechanical performance, firefly algorithm and deep reinforcement learning-based design optimization frameworks were developed with the purpose of maximizing the horizontal motion of the top surface of the actuators, while minimizing its corresponding effect on the vertical motion. Four optimized designs were fabricated. The actuators were tested and validated experimentally to demonstrate their required mechanical performance in order to regulate normal and shear stresses at the skin-pad interface for pressure injury prevention applications

Acoustic emission monitoring of propulsion systems : a laboratory study on a small gas turbine

The motivation of the work is to investigate a new, non-intrusive condition monitoring system for gas turbines with capabilities for earlier identification of any changes and the possibility of locating the source of the faults. This thesis documents experimental research conducted on a laboratory-scale gas turbine to assess the monitoring capabilities of Acoustic Emission (AE). In particular it focuses on understanding the AE behaviour of gas turbines under various normal and faulty running conditions. A series of tests was performed with the turbine running normally, either idling or with load. Two abnormal running configurations were also instrumented in which the impeller was either prevented from rotation or removed entirely. With the help of demodulated resonance analysis and an ANN it was possible to identify two types of AE; a background broadband source which is associated with gas flow and flow resistance, and a set of spectral frequency peaks which are associated with reverberation in the exhaust and coupling between the alternator and the turbine. A second series of experiments was carried out with an impeller which had been damaged by removal of the tips of some of the blades (two damaged blades and four damaged blades). The results show the potential capability of AE to identify gas turbine blade faults. The AE records showed two obvious indicators of blade faults, the first being that the energy in the AE signals becomes much higher and is distinctly periodic at higher speeds, and the second being the appearance of particular pulse patterns which can be characterized in the demodulated frequency domain

Sensing and Signal Processing in Smart Healthcare

In the last decade, we have witnessed the rapid development of electronic technologies that are transforming our daily lives. Such technologies are often integrated with various sensors that facilitate the collection of human motion and physiological data and are equipped with wireless communication modules such as Bluetooth, radio frequency identification, and near-field communication. In smart healthcare applications, designing ergonomic and intuitive human–computer interfaces is crucial because a system that is not easy to use will create a huge obstacle to adoption and may significantly reduce the efficacy of the solution. Signal and data processing is another important consideration in smart healthcare applications because it must ensure high accuracy with a high level of confidence in order for the applications to be useful for clinicians in making diagnosis and treatment decisions. This Special Issue is a collection of 10 articles selected from a total of 26 contributions. These contributions span the areas of signal processing and smart healthcare systems mostly contributed by authors from Europe, including Italy, Spain, France, Portugal, Romania, Sweden, and Netherlands. Authors from China, Korea, Taiwan, Indonesia, and Ecuador are also included

Characterization and processing of novel neck photoplethysmography signals for cardiorespiratory monitoring

Epilepsy is a neurological disorder causing serious brain seizures that severely affect the patients' quality of life. Sudden unexpected death in epilepsy (SUDEP), for which no evident decease reason is found after post-mortem examination, is a common cause of mortality. The mechanisms leading to SUDEP are uncertain, but, centrally mediated apneic respiratory dysfunction, inducing dangerous hypoxemia, plays a key role. Continuous physiological monitoring appears as the only reliable solution for SUDEP prevention. However, current seizure-detection systems do not show enough sensitivity and present a high number of intolerable false alarms. A wearable system capable of measuring several physiological signals from the same body location, could efficiently overcome these limitations. In this framework, a neck wearable apnea detection device (WADD), sensing airflow through tracheal sounds, was designed. Despite the promising performance, it is still necessary to integrate an oximeter sensor into the system, to measure oxygen saturation in blood (SpO2) from neck photoplethysmography (PPG) signals, and hence, support the apnea detection decision. The neck is a novel PPG measurement site that has not yet been thoroughly explored, due to numerous challenges. This research work aims to characterize neck PPG signals, in order to fully exploit this alternative pulse oximetry location, for precise cardiorespiratory biomarkers monitoring. In this thesis, neck PPG signals were recorded, for the first time in literature, in a series of experiments under different artifacts and respiratory conditions. Morphological and spectral characteristics were analyzed in order to identify potential singularities of the signals. The most common neck PPG artifacts critically corrupting the signal quality, and other breathing states of interest, were thoroughly characterized in terms of the most discriminative features. An algorithm was further developed to differentiate artifacts from clean PPG signals. Both, the proposed characterization and classification model can be useful tools for researchers to denoise neck PPG signals and exploit them in a variety of clinical contexts. In addition to that, it was demonstrated that the neck also offered the possibility, unlike other body parts, to extract the Jugular Venous Pulse (JVP) non-invasively. Overall, the thesis showed how the neck could be an optimum location for multi-modal monitoring in the context of diseases affecting respiration, since it not only allows the sensing of airflow related signals, but also, the breathing frequency component of the PPG appeared more prominent than in the standard finger location. In this context, this property enabled the extraction of relevant features to develop a promising algorithm for apnea detection in near-real time. These findings could be of great importance for SUDEP prevention, facilitating the investigation of the mechanisms and risk factors associated to it, and ultimately reduce epilepsy mortality.Open Acces

Towards standardisation in breathomics

Exhaled breath VOCs analysis is safe and non-invasive method of monitoring for human metabolic profiles and has the potential to become diagnostic tool in clinical practise. This thesis first describe in detail the different aspects of exhaled breath VOCs and its use as diagnostic tool in respiratory diseases. The current exhaled breath analysis work-flow including breath sampling, analysis and data processing is also described. A single exhaled breath sample can contain in excess of 500 different chemical species. There is a wide range of factors that can cause the variability to individual breath profiles. In order to detect small changes in breath profiles, a standardised and reproducible approach to exhaled breath analysis methodology is required. The long term storage of exhaled breath samples using multi-sorbent tubes is investigated, the optimum storage protocol and condition is discussed. A portable breath sampling system was also developed for remote sampling. The introduction of this new feature enables breath sampling to be carried out outside the designated laboratory with no location restriction. This feature combined with the easy to use and non-invasive original sampling unit designed for subjects with impaired lung function minimise participant stress level and discomfort. It also utilises the custom developed air supply filtration assembly to create a standardised purified breathable air that can minimise the method variability and improve standardisation to breath samples collected. This methodology is tested in an excise induced bronchoconstriction (EIB) study where two groups of participants: healthy and excise induced bronchoconstriction (EIB) positive undergo high intensity cardiopulmonary exercise testing (CPET). The data from two groups of participants is analysed and three markers which shown correlation with EIB positive participants are determined

Digital phenotyping through multimodal, unobtrusive sensing

The growing adoption of multimodal wearable and mobile devices, such as smartphones and wrist-worn watches has generated an increase in the collection of physiological and behavioural data at scale. This digital phenotyping data enables researchers to make inferences regarding users’ physical and mental health at scale, for the first time. However, translating this data into actionable insights requires computational approaches that turn unlabelled, multimodal time-series sensor data into validated measures that can be interpreted at scale. This thesis describes the derivation of novel computational methods that leverage digital phenotyping data from wearable devices in large-scale populations to infer physical behaviours. These methods combine insights from signal processing, data mining and machine learning alongside domain knowledge in physical activity and sleep epidemiology. First, the inference of sleeping windows in free-living conditions through a heart rate sensing approach is explored. This algorithm is particularly valuable in the absence of ground truth or sleep diaries given its simplicity, adaptability and capacity for personalization. I then explore multistage sleep classification through combined movement and cardiac wearable sensing and machine learning. Further, I demonstrate that postural changes detected through wrist accelerometers can inform habitual behaviours and are valuable complements to traditional, intensity-based physical activity metrics. I then leverage the concomitant responses of heart rate to physical activity that can be captured through multimodal wearable sensors through a self-supervised training task. The resulting embeddings from this task are shown to be useful for the downstream classification of demographic factors, BMI, energy expenditure and cardiorespiratory fitness. Finally, I describe a deep learning model for the adaptive inference of cardiorespiratory fitness (VO2max) using wearable data in free living conditions. I demonstrate the robustness of the model in a large UK population and show the models’ adaptability by evaluating its performance in a subset of the population with repeated measures ~6 years after the original recordings. Together, this work increases the potential of multimodal wearable and mobile sensors for physical activity and behavioural inferences in population studies. In particular, this thesis showcases the potential of using wearable devices to make valuable physical activity, sleep and fitness inferences in large cohort studies. Given the nature of the data collected and the fact that most of this data is currently generated by commercial providers and not research institutes, laying the foundations for responsible data governance and ethical use of these technologies will be critical to building trust and enabling the development of the field of digital phenotyping.I was funded by GlaxoSmithKline and the Engineering and Physical Sciences Research Council. I was also supported by the Alan Turing Institute through their Enrichment Scheme

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development