Predicting Renal Failure Progression in Chronic Kidney Disease Using Integrated Intelligent Fuzzy Expert System

Background. Chronic kidney disease (CKD) is a covert disease. Accurate prediction of CKD progression over time is necessary for reducing its costs and mortality rates. The present study proposes an adaptive neurofuzzy inference system (ANFIS) for predicting the renal failure timeframe of CKD based on real clinical data. Methods. This study used 10-year clinical records of newly diagnosed CKD patients. The threshold value of 15 cc/kg/min/1.73 m2 of glomerular filtration rate (GFR) was used as the marker of renal failure. A Takagi-Sugeno type ANFIS model was used to predict GFR values. Variables of age, sex, weight, underlying diseases, diastolic blood pressure, creatinine, calcium, phosphorus, uric acid, and GFR were initially selected for the predicting model. Results. Weight, diastolic blood pressure, diabetes mellitus as underlying disease, and current GFR(t) showed significant correlation with GFRs and were selected as the inputs of model. The comparisons of the predicted values with the real data showed that the ANFIS model could accurately estimate GFR variations in all sequential periods (Normalized Mean Absolute Error lower than 5%). Conclusions. Despite the high uncertainties of human body and dynamic nature of CKD progression, our model can accurately predict the GFR variations at long future periods

Designing and Implementing an ANFIS Based Medical Decision Support System to Predict Chronic Kidney Disease Progression

Background and objective: Chronic kidney disease (CKD) has a covert nature in its early stages that could postpone its diagnosis. Early diagnosis can reduce or prevent the progression of renal damage. The present study introduces an expert medical decision support system (MDSS) based on adaptive neuro-fuzzy inference system (ANFIS) to predict the timeframe of renal failure.Methods: The core system of the MDSS is a Takagi-Sugeno type ANFIS model that predicts the glomerular filtration rate (GFR) values as the biological marker of the renal failure. The model uses 10-year clinical records of newly diagnosed CKD patients and considers the threshold value of 15 cc/kg/min/1.73 m2 of GFR as the marker of renal failure. Following the evaluation of 10 variables, the ANFIS model uses the weight, diastolic blood pressure, and diabetes mellitus as underlying disease, and current GFR(t) as the inputs of the predicting model to predict the GFR values at future intervals. Then, a user-friendly graphical user interface of the model was built in MATLAB, in which the user can enter the physiological parameters obtained from patient recordings to determine the renal failure time as the output.Results: Assessing the performance of the MDSS against the real data of male and female CKD patients showed that this decision support model could accurately estimate GFR variations in all sequential periods of 6, 12, and 18 months, with a normalized mean absolute error lower than 5%. Despite the high uncertainties of the human body and the dynamic nature of CKD progression, our model can accurately predict the GFR variations at long future periods.Conclusions: The MDSS GUI could be useful in medical centers and used by experts to predict renal failure progression and, through taking effective actions, CKD can be prevented or effectively delayed

ROLE OF MACHINE VISION FOR IDENTIFICATION OF KIDNEY STONES USING MULTI FEATURES ANALYSIS

The purpose of this study is to highlight the significance of machine vision for the Classification of kidney stone identification. A novel optimized fused texture features frame work was designed to identify the stones in kidney.  A fused 234 texture feature namely (GLCM, RLM and Histogram) feature set was acquired by each region of interest (ROI). It was observed that on each image 8 ROI’s of sizes (16x16, 20x20 and 22x22) were taken. It was difficult to handle a large feature space 280800 (1200x234). Now to overcome this data handling issue we have applied feature optimization technique namely POE+ACC and acquired 30 most optimized features set for each ROI. The optimized fused features data set 3600(1200x30) was used to four machine vision Classifiers that is Random Forest, MLP, j48 and Naïve Bayes. Finally, it was observed that Random Forest provides best results of 90% accuracy on ROI 22x22 among the above discussed deployed Classifier

Applying Machine Learning Algorithms for the Analysis of Biological Sequences and Medical Records

The modern sequencing technology revolutionizes the genomic research and triggers explosive growth of DNA, RNA, and protein sequences. How to infer the structure and function from biological sequences is a fundamentally important task in genomics and proteomics fields. With the development of statistical and machine learning methods, an integrated and user-friendly tool containing the state-of-the-art data mining methods are needed. Here, we propose SeqFea-Learn, a comprehensive Python pipeline that integrating multiple steps: feature extraction, dimensionality reduction, feature selection, predicting model constructions based on machine learning and deep learning approaches to analyze sequences. We used enhancers, RNA N6- methyladenosine sites and protein-protein interactions datasets to evaluate the validation of the tool. The results show that the tool can effectively perform biological sequence analysis and classification tasks. Applying machine learning algorithms for Electronic medical record (EMR) data analysis is also included in this dissertation. Chronic kidney disease (CKD) is prevalent across the world and well defined by an estimated glomerular filtration rate (eGFR). The progression of kidney disease can be predicted if future eGFR can be accurately estimated using predictive analytics. Thus, I present a prediction model of eGFR that was built using Random Forest regression. The dataset includes demographic, clinical and laboratory information from a regional primary health care clinic. The final model included eGFR, age, gender, body mass index (BMI), obesity, hypertension, and diabetes, which achieved a mean coefficient of determination of 0.95. The estimated eGFRs were used to classify patients into CKD stages with high macro-averaged and micro-averaged metrics

Kidney Ailment Prediction under Data Imbalance

Chronic Kidney Disease (CKD) is the leading cause for kidney failure. It is a global health problem affecting approximately 10% of the world population and about 15% of US adults. Chronic Kidney Diseases do not generally show any disease specific symptoms in early stages thus it is hard to detect and prevent such diseases. Early detection and classification are the key factors in managing Chronic Kidney Diseases. In this thesis, we propose a new machine learning technique for Kidney Ailment Prediction. We focus on two key issues in machine learning, especially in its application to disease prediction. One is related to class imbalance problem. This occurs when at least one of the classes are represented by significantly smaller number of samples than the others in the training set. The problem with imbalanced dataset is that the classifiers tend to classify all samples as majority class, ignoring the minority class samples. The second issue is on the specific type of data to be used for a given problem. Here, we focused on predicting kidney diseases based on patient information extracted from laboratory and questionnaire data. Most recent approaches for predicting kidney diseases or other chronic diseases rely on the usage of prescription drugs. In this study, we focus on biomarker and anthropometry data of patients to analyze and predict kidney-related diseases. In this research, we adopted a learning approach which involves repeated random data sub-sampling to tackle the class imbalance problem. This technique divides the samples into multiple sub-samples, while keeping each training sub-sample completely balanced. We then trained classification models on the balanced data to predict the risk of kidney failure. Further, we developed an intelligent fusion mechanism to combine information from both the biomarker and anthropometry data sets for improved prediction accuracy and stability. Results are included to demonstrate the performance

Predicting outcomes in chronic kidney disease:needs and preferences of patients and nephrologists

Introduction: Guidelines on chronic kidney disease (CKD) recommend that nephrologists use clinical prediction models (CPMs). However, the actual use of CPMs seems limited in clinical practice. We conducted a national survey study to evaluate: 1) to what extent CPMs are used in Dutch CKD practice, 2) patients’ and nephrologists’ needs and preferences regarding predictions in CKD, and 3) determinants that may affect the adoption of CPMs in clinical practice. Methods: We conducted semi-structured interviews with CKD patients to inform the development of two online surveys; one for CKD patients and one for nephrologists. Survey participants were recruited through the Dutch Kidney Patient Association and the Dutch Federation of Nephrology. Results: A total of 126 patients and 50 nephrologists responded to the surveys. Most patients (89%) reported they had discussed predictions with their nephrologists. They most frequently discussed predictions regarded CKD progression: when they were expected to need kidney replacement therapy (KRT) (n = 81), and how rapidly their kidney function was expected to decline (n = 68). Half of the nephrologists (52%) reported to use CPMs in clinical practice, in particular CPMs predicting the risk of cardiovascular disease. Almost all nephrologists (98%) reported discussing expected CKD trajectories with their patients; even those that did not use CPMs (42%). The majority of patients (61%) and nephrologists (84%) chose a CPM predicting when patients would need KRT in the future as the most important prediction. However, a small portion of patients indicated they did not want to be informed on predictions regarding CKD progression at all (10–15%). Nephrologists not using CPMs (42%) reported they did not know CPMs they could use or felt that they had insufficient knowledge regarding CPMs. According to the nephrologists, the most important determinants for the adoption of CPMs in clinical practice were: 1) understandability for patients, 2) integration as standard of care, 3) the clinical relevance. Conclusion: Even though the majority of patients in Dutch CKD practice reported discussing predictions with their nephrologists, CPMs are infrequently used for this purpose. Both patients and nephrologists considered a CPM predicting CKD progression most important to discuss. Increasing awareness about existing CPMs that predict CKD progression may result in increased adoption in clinical practice. When using CPMs regarding CKD progression, nephrologists should ask whether patients want to hear predictions beforehand, since individual patients’ preferences vary.</p

Artificial intelligence methodologies and their application to diabetes

In the past decade diabetes management has been transformed by the addition of continuous glucose monitoring and insulin pump data. More recently, a wide variety of functions and physiologic variables, such as heart rate, hours of sleep, number of steps walked and movement, have been available through wristbands or watches. New data, hydration, geolocation, and barometric pressure, among others, will be incorporated in the future. All these parameters, when analyzed, can be helpful for patients and doctors' decision support. Similar new scenarios have appeared in most medical fields, in such a way that in recent years, there has been an increased interest in the development and application of the methods of artificial intelligence (AI) to decision support and knowledge acquisition. Multidisciplinary research teams integrated by computer engineers and doctors are more and more frequent, mirroring the need of cooperation in this new topic. AI, as a science, can be defined as the ability to make computers do things that would require intelligence if done by humans. Increasingly, diabetes-related journals have been incorporating publications focused on AI tools applied to diabetes. In summary, diabetes management scenarios have suffered a deep transformation that forces diabetologists to incorporate skills from new areas. This recently needed knowledge includes AI tools, which have become part of the diabetes health care. The aim of this article is to explain in an easy and plane way the most used AI methodologies to promote the implication of health care providers?doctors and nurses?in this field

Comparative Analysis of Some Prominent Machine Learning Algorithm for the Prediction of Chronic Kidney Disease

Chronic Kidney Disease (CKD) is a disorder against proper function regarding kidneys, as kidneys filter our blood whenever CKD gets worse, our blood receives wastes at a higher level, which results in sickness. It also has a substantial financial problem for families of subjects with a medical issue in&nbsp; Nigeria. Among the necessary measures that need action concerning the increase of CKD is detecting the disease early and with different data mining&nbsp; techniques. Data mining is gradually becoming more prevalent nowadays in healthcare, as also in fraud, abuse detection etc. Classification is a more&nbsp; useful data mining function to handle items in a collection to class or target categories. For obtaining essential information from medical database,&nbsp; machine learning and statistical analysis can assist in extracting hidden patterns and identify relationships from vast among of data. In this study, we&nbsp; compared five (5) different models namely: Deep Neural Network (DNN), Artificial Neural Network (ANN), Naïve Bayes (NB), Logistic Regression (LR), and&nbsp; K-Neighbor Nearest (KNN) to predict CKD on Gashua General Hospital (GGH) dataset. The study achieved an accuracy of 98% for DNN, KNN: 96%, NB:&nbsp; 97%, LR: 96% and ANN: 96%. The best performance was obtained with DNN with the highest accuracy and can be applied in real world application.&nbsp;&nbsp