Breast Cancer: Modelling and Detection

This paper reviews a number of the mathematical models used in cancer modelling and then chooses a specific cancer, breast carcinoma, to illustrate how the modelling can be used in aiding detection. We then discuss mathematical models that underpin mammographic image analysis, which complements models of tumour growth and facilitates diagnosis and treatment of cancer. Mammographic images are notoriously difficult to interpret, and we give an overview of the primary image enhancement technologies that have been introduced, before focusing on a more detailed description of some of our own recent work on the use of physics-based modelling in mammography. This theoretical approach to image analysis yields a wealth of information that could be incorporated into the mathematical models, and we conclude by describing how current mathematical models might be enhanced by use of this information, and how these models in turn will help to meet some of the major challenges in cancer detection

Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Abnormality Detection in Mammography using Deep Convolutional Neural Networks

Breast cancer is the most common cancer in women worldwide. The most common screening technology is mammography. To reduce the cost and workload of radiologists, we propose a computer aided detection approach for classifying and localizing calcifications and masses in mammogram images. To improve on conventional approaches, we apply deep convolutional neural networks (CNN) for automatic feature learning and classifier building. In computer-aided mammography, deep CNN classifiers cannot be trained directly on full mammogram images because of the loss of image details from resizing at input layers. Instead, our classifiers are trained on labelled image patches and then adapted to work on full mammogram images for localizing the abnormalities. State-of-the-art deep convolutional neural networks are compared on their performance of classifying the abnormalities. Experimental results indicate that VGGNet receives the best overall accuracy at 92.53\% in classifications. For localizing abnormalities, ResNet is selected for computing class activation maps because it is ready to be deployed without structural change or further training. Our approach demonstrates that deep convolutional neural network classifiers have remarkable localization capabilities despite no supervision on the location of abnormalities is provided.Comment: 6 page

Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

An Efficient Automatic Mass Classification Method In Digitized Mammograms Using Artificial Neural Network

In this paper we present an efficient computer aided mass classification method in digitized mammograms using Artificial Neural Network (ANN), which performs benign-malignant classification on region of interest (ROI) that contains mass. One of the major mammographic characteristics for mass classification is texture. ANN exploits this important factor to classify the mass into benign or malignant. The statistical textural features used in characterizing the masses are mean, standard deviation, entropy, skewness, kurtosis and uniformity. The main aim of the method is to increase the effectiveness and efficiency of the classification process in an objective manner to reduce the numbers of false-positive of malignancies. Three layers artificial neural network (ANN) with seven features was proposed for classifying the marked regions into benign and malignant and 90.91% sensitivity and 83.87% specificity is achieved that is very much promising compare to the radiologist's sensitivity 75%.Comment: 13 pages, 10 figure

Boundary Extraction in Images Using Hierarchical Clustering-based Segmentation

Hierarchical organization is one of the main characteristics of human segmentation. A human subject segments a natural image by identifying physical objects and marking their boundaries up to a certain level of detail [1]. Hierarchical clustering based segmentation (HCS) process mimics this capability of the human vision. The HCS process automatically generates a hierarchy of segmented images. The hierarchy represents the continuous merging of similar, spatially adjacent or disjoint, regions as the allowable threshold value of dissimilarity between regions, for merging, is gradually increased. HCS process is unsupervised and is completely data driven. This ensures that the segmentation process can be applied to any image, without any prior information about the image data and without any need for prior training of the segmentation process with the relevant image data. The implementation details of HCS process have been described elsewhere in the author's work [2]. The purpose of the current study is to demonstrate the performance of the HCS process in outlining boundaries in images and its possible application in processing medical images. [1] P. Arbelaez. Boundary Extraction in Natural Images Using Ultrametric Contour Maps. Proceedings 5th IEEE Workshop on Perceptual Organization in Computer Vision (POCV'06). June 2006. New York, USA. [2] A. N. Selvan. Highlighting Dissimilarity in Medical Images Using Hierarchical Clustering Based Segmentation (HCS). M. Phil. dissertation, Faculty of Arts Computing Engineering and Sciences Sheffield Hallam Univ., Sheffield, UK, 2007.</p