LaNi5 hydride cryogenic refrigerator test results

A complete LaNi5 hydrogen absorption cryogenic refrigerator system was developed. The system uses low temperature waste heat of approximately 100 C as a power source, and has no moving parts other than self operating valves. The cycle continues automatically by an electronic sequencing timing mechanism for the three compressors which are phased such that a constant supply of high pressure hydrogen gas is provided. It is indicated that with a fully clean hydrogen system, hundreds of thousand cycles should be attainable, even though some degradation may eventually occur. Simple vacuum reactivation of the hydride of moving parts, other than self operating, long life valves, the refrigerators predicted life is extremely long

Distributed Resources Shift Paradigms on Power System Design, Planning, and Operation: An Application of the GAP Model

Power systems have evolved following a century-old paradigm of planning and operating a grid based on large central generation plants connected to load centers through a transmission grid and distribution lines with radial flows. This paradigm is being challenged by the development and diffusion of modular generation and storage technologies. We use a novel approach to assess the sequencing and pacing of centralized, distributed, and off-grid electrification strategies by developing and employing the grid and access planning (GAP) model. GAP is a capacity expansion model to jointly assess operation and investment in utility-scale generation, transmission, distribution, and demand-side resources. This paper conceptually studies the investment and operation decisions for a power system with and without distributed resources. Contrary to the current practice, we find hybrid systems that pair grid connections with distributed energy resources (DERs) are the preferred mode of electricity supply for greenfield expansion under conservative reductions in photovoltaic panel (PV) and energy storage prices. We also find that when distributed PV and storage are employed in power system expansion, there are savings of 15%-20% mostly in capital deferment and reduced diesel use. Results show that enhanced financing mechanisms for DER PV and storage could enable 50%-60% of additional deployment and save 15 /MWh in system costs. These results have important implications to reform current utility business models in developed power systems and to guide the development of electrification strategies in underdeveloped grids

Optimal Rotational Load Shedding via Bilinear Integer Programming

This paper addresses the problem of managing rotational load shedding schedules for a power distribution network with multiple load zones. An integer optimization problem is formulated to find the optimal number and duration of planned power outages. Various types of damage costs are proposed to capture the heterogeneous load shedding preferences of different zones. The McCormick relaxation along with an effective procedure feasibility recovery is developed to solve the resulting bilinear integer program, which yields a high-quality suboptimal solution. Extensive simulation results corroborate the merit of the proposed approach, which has a substantial edge over existing load shedding schemes.Comment: 6 pages, 11 figures. To appear at the conference of APSIPA ASC 201

Entirely off-grid and solar-powered DNA sequencing of microbial communities during an ice cap traverse expedition

Microbial communities in remote locations remain under-studied. This is particularly true on glaciers and icecaps, which cover approximately 11% of the Earth’s surface. The principal reason for this is the inaccessibility of most of these areas due to their extreme isolation and challenging environmental conditions. While remote research stations have significantly lowered the barrier to studying the microbial communities on icecaps, their use has led to a bias for data collection in the near vicinity of these institutions. Here, miniaturisation of a DNA sequencing lab suitable for off-grid metagenomic studies is demonstrated. Using human power alone, this lab was transported across Europe’s largest ice cap (Vatnajökull, Iceland) by ski and sledge. After 11 days of unsupported polar-style travel, a metagenomic study of a geothermal hot spring gorge was conducted on the remote northern edge of the ice cap. This tent-based metagenomic study resulted in over 24 h of Nanopore sequencing, powered by solar power alone. This study demonstrates the ability to conduct DNA sequencing in remote locations, far from civilised resources (mechanised transport, external power supply, internet connection, etc.), whilst greatly reducing the time from sample collection to data acquisition

Applications and Challenges of Real-time Mobile DNA Analysis

The DNA sequencing is the process of identifying the exact order of nucleotides within a given DNA molecule. The new portable and relatively inexpensive DNA sequencers, such as Oxford Nanopore MinION, have the potential to move DNA sequencing outside of laboratory, leading to faster and more accessible DNA-based diagnostics. However, portable DNA sequencing and analysis are challenging for mobile systems, owing to high data throughputs and computationally intensive processing performed in environments with unreliable connectivity and power. In this paper, we provide an analysis of the challenges that mobile systems and mobile computing must address to maximize the potential of portable DNA sequencing, and in situ DNA analysis. We explain the DNA sequencing process and highlight the main differences between traditional and portable DNA sequencing in the context of the actual and envisioned applications. We look at the identified challenges from the perspective of both algorithms and systems design, showing the need for careful co-design

PolyTB: a genomic variation map for Mycobacterium tuberculosis

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second major cause of death from an infectious disease worldwide. Recent advances in DNA sequencing are leading to the ability to generate whole genome information in clinical isolates of M. tuberculosis complex (MTBC). The identification of informative genetic variants such as phylogenetic markers and those associated with drug resistance or virulence will help barcode Mtb in the context of epidemiological, diagnostic and clinical studies. Mtb genomic datasets are increasingly available as raw sequences, which are potentially difficult and computer intensive to process, and compare across studies. Here we have processed the raw sequence data (>1500 isolates, eight studies) to compile a catalogue of SNPs (n = 74,039, 63% non-synonymous, 51.1% in more than one isolate, i.e. non-private), small indels (n = 4810) and larger structural variants (n = 800). We have developed the PolyTB web-based tool (http://pathogenseq.lshtm.ac.uk/polytb) to visualise the resulting variation and important meta-data (e.g. in silico inferred strain-types, location) within geographical map and phylogenetic views. This resource will allow researchers to identify polymorphisms within candidate genes of interest, as well as examine the genomic diversity and distribution of strains. PolyTB source code is freely available to researchers wishing to develop similar tools for their pathogen of interest