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The role of HG in the analysis of temporal iteration and interaural correlation
An In-Depth Statistical Review of Retinal Image Processing Models from a Clinical Perspective
The burgeoning field of retinal image processing is critical in facilitating early diagnosis and treatment of retinal diseases, which are amongst the leading causes of vision impairment globally. Despite rapid advancements, existing machine learning models for retinal image processing are characterized by significant limitations, including disparities in pre-processing, segmentation, and classification methodologies, as well as inconsistencies in post-processing operations. These limitations hinder the realization of accurate, reliable, and clinically relevant outcomes. This paper provides an in-depth statistical review of extant machine learning models used in retinal image processing, meticulously comparing them based on their internal operating characteristics and performance levels. By adopting a robust analytical approach, our review delineates the strengths and weaknesses of current models, offering comprehensive insights that are instrumental in guiding future research and development in this domain. Furthermore, this review underscores the potential clinical impacts of these models, highlighting their pivotal role in enhancing diagnostic accuracy, prognostic assessments, and therapeutic interventions for retinal disorders. In conclusion, our work not only bridges the existing knowledge gap in the literature but also paves the way for the evolution of more sophisticated and clinically-aligned retinal image processing models, ultimately contributing to improved patient outcomes and advancements in ophthalmic care
RetiFluidNet: A Self-Adaptive and Multi-Attention Deep Convolutional Network for Retinal OCT Fluid Segmentation
Optical coherence tomography (OCT) helps ophthalmologists assess macular
edema, accumulation of fluids, and lesions at microscopic resolution.
Quantification of retinal fluids is necessary for OCT-guided treatment
management, which relies on a precise image segmentation step. As manual
analysis of retinal fluids is a time-consuming, subjective, and error-prone
task, there is increasing demand for fast and robust automatic solutions. In
this study, a new convolutional neural architecture named RetiFluidNet is
proposed for multi-class retinal fluid segmentation. The model benefits from
hierarchical representation learning of textural, contextual, and edge features
using a new self-adaptive dual-attention (SDA) module, multiple self-adaptive
attention-based skip connections (SASC), and a novel multi-scale deep self
supervision learning (DSL) scheme. The attention mechanism in the proposed SDA
module enables the model to automatically extract deformation-aware
representations at different levels, and the introduced SASC paths further
consider spatial-channel interdependencies for concatenation of counterpart
encoder and decoder units, which improve representational capability.
RetiFluidNet is also optimized using a joint loss function comprising a
weighted version of dice overlap and edge-preserved connectivity-based losses,
where several hierarchical stages of multi-scale local losses are integrated
into the optimization process. The model is validated based on three publicly
available datasets: RETOUCH, OPTIMA, and DUKE, with comparisons against several
baselines. Experimental results on the datasets prove the effectiveness of the
proposed model in retinal OCT fluid segmentation and reveal that the suggested
method is more effective than existing state-of-the-art fluid segmentation
algorithms in adapting to retinal OCT scans recorded by various image scanning
instruments.Comment: 11 pages, Early Access Version, IEEE Transactions on Medical Imagin
Deep Learning in Cardiology
The medical field is creating large amount of data that physicians are unable
to decipher and use efficiently. Moreover, rule-based expert systems are
inefficient in solving complicated medical tasks or for creating insights using
big data. Deep learning has emerged as a more accurate and effective technology
in a wide range of medical problems such as diagnosis, prediction and
intervention. Deep learning is a representation learning method that consists
of layers that transform the data non-linearly, thus, revealing hierarchical
relationships and structures. In this review we survey deep learning
application papers that use structured data, signal and imaging modalities from
cardiology. We discuss the advantages and limitations of applying deep learning
in cardiology that also apply in medicine in general, while proposing certain
directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table
A new convolutional neural network based on combination of circlets and wavelets for macular OCT classification
Artificial intelligence (AI) algorithms, encompassing machine learning and deep learning, can assist ophthalmologists in early detection of various ocular abnormalities through the analysis of retinal optical coherence tomography (OCT) images. Despite considerable progress in these algorithms, several limitations persist in medical imaging fields, where a lack of data is a common issue. Accordingly, specific image processing techniques, such as time–frequency transforms, can be employed in conjunction with AI algorithms to enhance diagnostic accuracy. This research investigates the influence of non-data-adaptive time–frequency transforms, specifically X-lets, on the classification of OCT B-scans. For this purpose, each B-scan was transformed using every considered X-let individually, and all the sub-bands were utilized as the input for a designed 2D Convolutional Neural Network (CNN) to extract optimal features, which were subsequently fed to the classifiers. Evaluating per-class accuracy shows that the use of the 2D Discrete Wavelet Transform (2D-DWT) yields superior outcomes for normal cases, whereas the circlet transform outperforms other X-lets for abnormal cases characterized by circles in their retinal structure (due to the accumulation of fluid). As a result, we propose a novel transform named CircWave by concatenating all sub-bands from the 2D-DWT and the circlet transform. The objective is to enhance the per-class accuracy of both normal and abnormal cases simultaneously. Our findings show that classification results based on the CircWave transform outperform those derived from original images or any individual transform. Furthermore, Grad-CAM class activation visualization for B-scans reconstructed from CircWave sub-bands highlights a greater emphasis on circular formations in abnormal cases and straight lines in normal cases, in contrast to the focus on irrelevant regions in original B-scans. To assess the generalizability of our method, we applied it to another dataset obtained from a different imaging system. We achieved promising accuracies of 94.5% and 90% for the first and second datasets, respectively, which are comparable with results from previous studies. The proposed CNN based on CircWave sub-bands (i.e. CircWaveNet) not only produces superior outcomes but also offers more interpretable results with a heightened focus on features crucial for ophthalmologists
Optic-Net: A Novel Convolutional Neural Network for Diagnosis of Retinal Diseases from Optical Tomography Images
Diagnosing different retinal diseases from Spectral Domain Optical Coherence
Tomography (SD-OCT) images is a challenging task. Different automated
approaches such as image processing, machine learning and deep learning
algorithms have been used for early detection and diagnosis of retinal
diseases. Unfortunately, these are prone to error and computational
inefficiency, which requires further intervention from human experts. In this
paper, we propose a novel convolution neural network architecture to
successfully distinguish between different degeneration of retinal layers and
their underlying causes. The proposed novel architecture outperforms other
classification models while addressing the issue of gradient explosion. Our
approach reaches near perfect accuracy of 99.8% and 100% for two separately
available Retinal SD-OCT data-set respectively. Additionally, our architecture
predicts retinal diseases in real time while outperforming human
diagnosticians.Comment: 8 pages. Accepted to 18th IEEE International Conference on Machine
Learning and Applications (ICMLA 2019
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