24,764 research outputs found

    Distributed service orchestration : eventually consistent cloud operation and integration

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    Both researchers and industry players are facing the same obstacles when entering the big data field. Deploying and testing distributed data technologies requires a big up-front investment of both time and knowledge. Existing cloud automation solutions are not well suited for managing complex distributed data solutions. This paper proposes a distributed service orchestration architecture to better handle the complex orchestration logic needed in these cases. A novel service-engine based approach is proposed to cope with the versatility of the individual components. A hybrid integration approach bridges the gap between cloud modeling languages, automation artifacts, image-based schedulers and PaaS solutions. This approach is integrated in the distributed data experimentation platform Tengu, making it more flexible and robust

    Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases

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    Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible, including biomarkers, genomic profiles, cognitive and behavioral phenotypes, high-frequency assessments, and medical imaging. Although these data are incredibly complex, they can potentially be used to understand multi-determinant causal relationships, elucidate modifiable factors, and ultimately customize treatments based on individual parameters. Especially for neurodegenerative diseases, where an effective therapeutic agent has yet to be discovered, there remains a critical need for an interdisciplinary perspective on data and information management due to the number of unanswered questions. Biomedical informatics is a multidisciplinary field that falls at the intersection of information technology, computer and data science, engineering, and healthcare that will be instrumental for uncovering novel insights into neurodegenerative disease research, including both causal relationships and therapeutic targets and maximizing the utility of both clinical and research data. The present study aims to provide a brief overview of biomedical informatics and how clinical data applications such as clinical decision support tools can be developed to derive new knowledge from the wealth of available data to advance clinical care and scientific research of neurodegenerative diseases in the era of precision medicine

    White paper – On the use of LiDAR data at AmeriFlux sites

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    Our aim is to inform the AmeriFlux community on existing and upcoming LiDAR technologies (atmospheric Doppler or Raman LiDAR often deployed at flux sites are not considered here), how it is currently used at flux sites, and how we believe it could, in the future, further contribute to the AmeriFlux vision. Heterogeneity in vegetation and ground properties at various spatial scales is omnipresent at flux sites, and 3D mapping of canopy, understory, and ground surface can help move the science forward
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