Information visualization for DNA microarray data analysis: A critical review

Graphical representation may provide effective means of making sense of the complexity and sheer volume of data produced by DNA microarray experiments that monitor the expression patterns of thousands of genes simultaneously. The ability to use ldquoabstractrdquo graphical representation to draw attention to areas of interest, and more in-depth visualizations to answer focused questions, would enable biologists to move from a large amount of data to particular records they are interested in, and therefore, gain deeper insights in understanding the microarray experiment results. This paper starts by providing some background knowledge of microarray experiments, and then, explains how graphical representation can be applied in general to this problem domain, followed by exploring the role of visualization in gene expression data analysis. Having set the problem scene, the paper then examines various multivariate data visualization techniques that have been applied to microarray data analysis. These techniques are critically reviewed so that the strengths and weaknesses of each technique can be tabulated. Finally, several key problem areas as well as possible solutions to them are discussed as being a source for future work

Performance comparison of point and spatial access methods

In the past few years a large number of multidimensional point access methods, also called multiattribute index structures, has been suggested, all of them claiming good performance. Since no performance comparison of these structures under arbitrary (strongly correlated nonuniform, short "ugly") data distributions and under various types of queries has been performed, database researchers and designers were hesitant to use any of these new point access methods. As shown in a recent paper, such point access methods are not only important in traditional database applications. In new applications such as CAD/CIM and geographic or environmental information systems, access methods for spatial objects are needed. As recently shown such access methods are based on point access methods in terms of functionality and performance. Our performance comparison naturally consists of two parts. In part I we w i l l compare multidimensional point access methods, whereas in part I I spatial access methods for rectangles will be compared. In part I we present a survey and classification of existing point access methods. Then we carefully select the following four methods for implementation and performance comparison under seven different data files (distributions) and various types of queries: the 2-level grid file, the BANG file, the hB-tree and a new scheme, called the BUDDY hash tree. We were surprised to see one method to be the clear winner which was the BUDDY hash tree. It exhibits an at least 20 % better average performance than its competitors and is robust under ugly data and queries. In part I I we compare spatial access methods for rectangles. After presenting a survey and classification of existing spatial access methods we carefully selected the following four methods for implementation and performance comparison under six different data files (distributions) and various types of queries: the R-tree, the BANG file, PLOP hashing and the BUDDY hash tree. The result presented two winners: the BANG file and the BUDDY hash tree. This comparison is a first step towards a standardized testbed or benchmark. We offer our data and query files to each designer of a new point or spatial access method such that he can run his implementation in our testbed

Quantifying perception of nonlinear elastic tissue models using multidimensional scaling

Simplified soft tissue models used in surgical simulations cannot perfectly reproduce all material behaviors. In particular, many tissues exhibit the Poynting effect, which results in normal forces during shearing of tissue and is only observed in nonlinear elastic material models. In order to investigate and quantify the role of the Poynting effect on material discrimination, we performed a multidimensional scaling (MDS) study. Participants were presented with several pairs of shear and normal forces generated by a haptic device during interaction with virtual soft objects. Participants were asked to rate the similarity between the forces felt. The selection of the material parameters – and thus the magnitude of the shear\ud and normal forces – was based on a pre-study prior to the MDS experiment. It was observed that for nonlinear elastic tissue models exhibiting the Poynting effect, MDS analysis indicated that both shear and normal forces affect user perception

Data driven wireless network design : a multi-level modeling approach

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ASSESSING THE RELATIVE INFLUENCES OF ABIOTIC AND BIOTIC FACTORS ON A SPECIES’ DISTRIBUTION USING PSEUDO-ABSENCE AND FUNCTIONAL TRAIT DATA: A CASE STUDY WITH THE AMERICAN EEL (Anguilla rostrata)

Species’ distributions are influenced by abiotic and biotic factors but direct comparison of their relative importance is difficult, particularly when working with complex, multi-species datasets. Here, we present a flexible method to compare abiotic and biotic influences at common scales. First, data representing abiotic and biotic factors are collected using a combination of geographic information system, remotely sensed, and species’ functional trait data. Next, the relative influences of each predictor variable on the occurrence of a focal species are compared. Specifically, ‘sample’ data from sites of known occurrence are compared with ‘background’ data (i.e. pseudo-absence data collected at sites where occurrence is unknown, combined with sample data). Predictor variables that may have the strongest influence on the focal species are identified as those where sample data are clearly distinct from the corresponding background distribution. To demonstrate the method, effects of hydrology, physical habitat, and co-occurring fish functional traits are assessed relative to the contemporary (1950 – 1990) distribution of the American Eel (Anguilla rostrata) in six Mid-Atlantic (USA) rivers. We find that Eel distribution has likely been influenced by the functional characteristics of co-occurring fishes and by local dam density, but not by other physical habitat or hydrologic factors