3 research outputs found
Epilepsy
With the vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, InTech proudly presents the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well
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Investigating the function of alpha frequency oscillatory activity
This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonA fundamental challenge in modern neuroscience is to understand the role of synchronous oscillatory activity of groups of neurons in information processing. This thesis addressed the problem of how alpha frequency oscillatory activity might help control the flow of information from both the external world and from higher cognitive areas (responsible for inhibitory control, top-down and bottom-up information flow). A series of experiments investigated how alpha neuronal dynamics might aid/control cognition. In order to study the functional significance of alpha frequency oscillatory activity, the effects on performance in cognitive tasks of alpha activity directly elicited using photic stimulation were examined. Initially, we were interested in the role of alpha oscillations in information transfer across cortical areas, which was probed using a numerical Stroop task with every trial preceded by a flicker prime. The incongruent trials of the Stroop task introduce a conflict between competing responses which results in people being slower in responses to the task compared with congruent trials. That slower response has been related to increased communication between conflict processing fronto-parietal and early somatosensory regions. If alpha oscillations improve communication efficiency across the cortex it was predicted that inducing stronger alpha oscillations would affect the performance, (i.e. the Stroop cost would diminish). That hypothesis was tested in a series of three experiments. None of the manipulations (different frequencies, amplitudes induced and alpha phases where the Stroop task was initiated) showed that alpha oscillatory activity reduces the Stroop effect. However, the last task showed that people were faster when the task was preceded by an alpha frequency flicker prime, especially around 10Hz. The fourth experiment built on the well-established phenomena that when alpha activity is elicited in a particular hemisphere it attenuates processing of sensory information in that hemisphere, while the opposite hemisphere, is characterised by increased efficiency of information processing/flow. The study tested whether that could occur within a hemisphere by localised entrainment of part of the visual field. This hypothesis was tested by examining whether it could resolve differences in results previously published by Mathewson et al., (2012) and Spaak et al., (2014). In this study, a target circle was presented at time points after the offset of an alpha flicker prime, such that it was either in or out of phase with the prime. The target was displayed briefly, and then a masking ring appeared around the target location. There were two experimental conditions. First priming occurred at the central target location, and this was expected to inhibit perception at that location, (i.e. the target would be best detected at out of alpha phase time points). In contrast, in the second condition, the target surround area (e.g. the mask location) was stimulated, and this was expected to inhibit perception at that location, (i.e. the mask would be most effective in phase time points and so the target more easily detected). However, in both instances, target detection was best at in-phase time points and attenuated at out of phase time points, in line with Mathewson et al., (2012) results. This gives us some insight into the role of the alpha phase in allowing the external stimuli to be perceived/detected. The fifth experiment tested whether the level of spatial uncertainty of briefly presented target determines the alpha phase position for its best detection. This task used a similar masked circle paradigm as the fourth experiment, but the target could appear at one of two locations either side of fixation, which were both preceded by a flicker prime (either alpha frequency or randomly jittered) and followed by masking rings. The hypothesis was that the optimal alpha phase for target detection depends on whether people are pre-guided (by an arrow cue) to the target location or uncued (a higher level of spatial uncertainty). This hypothesis was again tested by examining whether it could resolve differences in results previously published by Mathewson et al., (2012) and Spaak et al., (2014). This experiment showed that the level of spatial uncertainty of briefly presented target determines the optimal alpha phase for its detection. Targets whose location was not pre-guided were the most likely to be detected when presented at time points out of phase with the entrained alpha prime; targets whose location was pre-guided by a brief arrow were the most likely to be detected when presented at time points in phase with the entrained alpha prime. The sixth experiment used EEG to investigate the neural dynamics underlying the behaviourally tested phenomenon in the previous experiment. Results showed that for targets with a high level of spatial uncertainty, the average alpha power peak was detected earlier in anterior electrodes compared with posterior electrodes, which is consistent with a greater reliance on alpha top-down dynamics. In contrast, for targets at a spatially cued location, the average alpha power peak was detected earlier at posterior electrodes, which suggests a greater reliance on bottom-up alpha neuronal dynamics. In summary, this thesis confirmed that mid-alpha phase determines the probability of detection of a briefly presented target. Also, it showed that optimal alpha phase for detecting briefly presented target would differ depending on the level of spatial uncertainty of that target. Targets at non-predictable locations are more likely to be detected at a trough in the phase of alpha activity whilst those at cued locations are most likely to be detected in-phase. Hence, perception depends not only on the internal neuronal alpha dynamics but also on the type of the visual percept. This difference may highlight the role of two different neuronal alpha sources which dominate in the different scenarios. When the target location is uncertain, top-down alpha dynamics dominate. However, when the target location is pre-guided, bottom-up alpha dynamics dominate
New approaches for EEG signal processing: artifact EOG removal by ICA-RLS scheme and tracks extraction method
Localizing the bioelectric phenomena originating from the cerebral cortex
and evoked by auditory and somatosensory stimuli are clear objectives to
both understand how the brain works and to recognize different pathologies.
Diseases such as Parkinsonâs, Alzheimerâs, schizophrenia and epilepsy are intensively
studied to find a cure or accurate diagnosis.
Epilepsy is considered the disease with major prevalence within disorders
with neurological origin. The recurrent and sudden incidence of seizures can
lead to dangerous and possibly life-threatening situations. Since disturbance
of consciousness and sudden loss of motor control often occur without any
warning, the ability to predict epileptic seizures would reduce patientsâ anxiety,
thus considerably improving quality of life and safety.
The common procedure for epilepsy seizure detection is based on brain
activity monitorization via electroencephalogram (EEG) data. This process
consumes a lot of time, especially in the case of long recordings, but the major
problem is the subjective nature of the analysis among specialists when
analyzing the same record. From this perspective, the identification of hidden
dynamical patterns is necessary because they could provide insight into
the underlying physiological mechanisms that occur in the brain.
Time-frequency distributions (TFDs) and adaptive methods have demonstrated
to be good alternatives in designing systems for detecting neurodegenerative
diseases. TFDs are appropriate transformations because they offer
the possibility of analyzing relatively long continuous segments of EEG data
even when the dynamics of the signal are rapidly changing. On the other
hand, most of the detection methods proposed in the literature assume a
clean EEG signal free of artifacts or noise, leaving the preprocessing problem
opened to any denoising algorithm.
In this thesis we have developed two proposals for EEG signal processing:
the first approach consists in electrooculogram (EOG) removal method based
on a combination of ICA and RLS algorithms which automatically cancels
the artifacts produced by eyes movement without the use of external âad
hocâ electrode. This method, called ICA-RLS has been compared with other
techniques that are in the state of the art and has shown to be a good
alternative for artifacts rejection. The second approach is a novel method
in EEG features extraction called tracks extraction (LFE features). This
method is based on the TFDs and partial tracking. Our results in pattern
extractions related to epileptic seizures have shown that tracks extraction is
appropriate in EEG detection and classification tasks, being practical, easily applicable in medical environment and has acceptable computational cost