Design of Neuromemristive Systems for Visual Information Processing

Neuromemristive systems (NMSs) are brain-inspired, adaptive computer architectures based on emerging resistive memory technology (memristors). NMSs adopt a mixed-signal design approach with closely-coupled memory and processing, resulting in high area and energy efficiencies. Previous work suggests that NMSs could even supplant conventional architectures in niche application domains such as visual information processing. However, given the infancy of the field, there are still several obstacles impeding the transition of these systems from theory to practice. This dissertation advances the state of NMS research by addressing open design problems spanning circuit, architecture, and system levels. Novel synapse, neuron, and plasticity circuits are designed to reduce NMSs’ area and power consumption by using current-mode design techniques and exploiting device variability. Circuits are designed in a 45 nm CMOS process with memristor models based on multilevel (W/Ag-chalcogenide/W) and bistable (Ag/GeS2/W) device data. Higher-level behavioral, power, area, and variability models are ported into MATLAB to accelerate the overall simulation time. The circuits designed in this work are integrated into neural network architectures for visual information processing tasks, including feature detection, clustering, and classification. Networks in the NMSs are trained with novel stochastic learning algorithms that achieve 3.5 reduction in circuit area, reduced design complexity, and exhibit similar convergence properties compared to the least-mean-squares algorithm. This work also examines the effects of device-level variations on NMS performance, which has received limited attention in previous work. The impact of device variations is reduced with a partial on-chip training methodology that enables NMSs to be configured with relatively sophisticated algorithms (e.g. resilient backpropagation), while maximizing their area-accuracy tradeoff

Kablosuz sensör ağlarinda yönlü antenlerle enerji̇ veri̇mli̇ yönlendi̇rme

Without measurements, sustainable development effort can not progress in the right direction. Wireless sensor networks are vital for monitoring in real time and making accurate measurements for such an endeavor. However small energy storage in the sensors can become a bottleneck if the wireless sensor network is not optimized at the hardware and software level. Directional antennas are such optimization technologies at the hardware level. They have advantages over the omnidirectional antennas, such as high gain, less interference, longer transmission range, and less power consumption. In wireless sensor networks, most of the energy is consumed for communication. Considering the limited energy in small scale batteries of the sensors, energy efficient (aware) routing, is one of the most important software optimization techniques. The main goal of the technique is to improve the lifetime of the wireless sensor networks. In the light of these observations, it is desirable to do a coupled design of directional antennas with network software, for fully exploiting the advantages offered by directional antenna technology. In this thesis, the possibilities of doing such integrated design are surveyed and improvements are suggested. The design of the proposed microstrip patch antenna array is discussed and the performance characteristics are assessed through simulations. In the benchmarks, the proposed routing method showed improvements in energy usage compared to the existing approaches.Ölçümler olmadan sürdürülebilir kalkınma çabaları doğru yönde ilerleyemez. Bu tür çabalar için, kablosuz sensör ağları, gerçek zamanlı olarak izleme ve kesin ölçümler yapmak için vazgeçilemez unsurdur. Ancak, sensör ağı, donanım ve yazılım düzeylerinde optimize edilmemişse, sensörlerde enerji yetersizliği görülebilinir. Yönlü antenler, donanım düzeyinde uygulanan optimizasyon teknolojilerinden biri olmakla birlikte, çok yönlü antenlerden farklı olarak, yüksek kazanç, daha az parazit, daha uzun iletim mesafesi ve daha az güç tüketimi sağlarlar. Kablosuz sensör ağlarında enerjinin çoğu iletişim için tüketilir. Sensörlerdeki limitli enerjili küçük ölçekli piller göz önüne alındığında, yazılım düzeyindeki önemli metodlardan biri olan enerji verimli (duyarlı) yönlendirme protokolü, kablosuz sensör ağının genel enerji kullanımını optimize etmek ve ömrünü uzatmak için gereklidir. Bu gözlemlerin ışığında, yönlü anten teknolojisinin sunduğu potansiyel avantajlardan tam olarak yararlanmak için, yönlü antenlerin ağ yazılımıyla birlikte entegre tasarımını yapmak arzu edilir. Bu tezde, böyle bir entegre tasarımın yapılma olasılıkları araştırılmış ve iyileştirmeler önerilmiştir. Tezde, küçük şeritli yamalı anten dizisinin tasarımı tartışılmış ve performans karakteristikleri simulasyonlarla ölçülmüştür. Önerilen yönlendirme algoritması, diğer yönlendirme algoritmaları ile karşılaştırıldığında, enerji kullanımında iyileştirmeler göstermiştirM.S. - Master of Scienc

Broadcast-oriented wireless network-on-chip : fundamentals and feasibility

Premi extraordinari doctorat UPC curs 2015-2016, àmbit Enginyeria de les TICRecent years have seen the emergence and ubiquitous adoption of Chip Multiprocessors (CMPs), which rely on the coordinated operation of multiple execution units or cores. Successive CMP generations integrate a larger number of cores seeking higher performance with a reasonable cost envelope. For this trend to continue, however, important scalability issues need to be solved at different levels of design. Scaling the interconnect fabric is a grand challenge by itself, as new Network-on-Chip (NoC) proposals need to overcome the performance hurdles found when dealing with the increasingly variable and heterogeneous communication demands of manycore processors. Fast and flexible NoC solutions are needed to prevent communication become a performance bottleneck, situation that would severely limit the design space at the architectural level and eventually lead to the use of software frameworks that are slow, inefficient, or less programmable. The emergence of novel interconnect technologies has opened the door to a plethora of new NoCs promising greater scalability and architectural flexibility. In particular, wireless on-chip communication has garnered considerable attention due to its inherent broadcast capabilities, low latency, and system-level simplicity. Most of the resulting Wireless Network-on-Chip (WNoC) proposals have set the focus on leveraging the latency advantage of this paradigm by creating multiple wireless channels to interconnect far-apart cores. This strategy is effective as the complement of wired NoCs at moderate scales, but is likely to be overshadowed at larger scales by technologies such as nanophotonics unless bandwidth is unrealistically improved. This dissertation presents the concept of Broadcast-Oriented Wireless Network-on-Chip (BoWNoC), a new approach that attempts to foster the inherent simplicity, flexibility, and broadcast capabilities of the wireless technology by integrating one on-chip antenna and transceiver per processor core. This paradigm is part of a broader hybrid vision where the BoWNoC serves latency-critical and broadcast traffic, tightly coupled to a wired plane oriented to large flows of data. By virtue of its scalable broadcast support, BoWNoC may become the key enabler of a wealth of unconventional hardware architectures and algorithmic approaches, eventually leading to a significant improvement of the performance, energy efficiency, scalability and programmability of manycore chips. The present work aims not only to lay the fundamentals of the BoWNoC paradigm, but also to demonstrate its viability from the electronic implementation, network design, and multiprocessor architecture perspectives. An exploration at the physical level of design validates the feasibility of the approach at millimeter-wave bands in the short term, and then suggests the use of graphene-based antennas in the terahertz band in the long term. At the link level, this thesis provides an insightful context analysis that is used, afterwards, to drive the design of a lightweight protocol that reliably serves broadcast traffic with substantial latency improvements over state-of-the-art NoCs. At the network level, our hybrid vision is evaluated putting emphasis on the flexibility provided at the network interface level, showing outstanding speedups for a wide set of traffic patterns. At the architecture level, the potential impact of the BoWNoC paradigm on the design of manycore chips is not only qualitatively discussed in general, but also quantitatively assessed in a particular architecture for fast synchronization. Results demonstrate that the impact of BoWNoC can go beyond simply improving the network performance, thereby representing a possible game changer in the manycore era.Avenços en el disseny de multiprocessadors han portat a una àmplia adopció dels Chip Multiprocessors (CMPs), que basen el seu potencial en la operació coordinada de múltiples nuclis de procés. Generacions successives han anat integrant més nuclis en la recerca d'alt rendiment amb un cost raonable. Per a que aquesta tendència continuï, però, cal resoldre importants problemes d'escalabilitat a diferents capes de disseny. Escalar la xarxa d'interconnexió és un gran repte en ell mateix, ja que les noves propostes de Networks-on-Chip (NoC) han de servir un tràfic eminentment variable i heterogeni dels processadors amb molts nuclis. Són necessàries solucions ràpides i flexibles per evitar que les comunicacions dins del xip es converteixin en el pròxim coll d'ampolla de rendiment, situació que limitaria en gran mesura l'espai de disseny a nivell d'arquitectura i portaria a l'ús d'arquitectures i models de programació lents, ineficients o poc programables. L'aparició de noves tecnologies d'interconnexió ha possibilitat la creació de NoCs més flexibles i escalables. En particular, la comunicació intra-xip sense fils ha despertat un interès considerable en virtut de les seva baixa latència, simplicitat, i bon rendiment amb tràfic broadcast. La majoria de les Wireless NoC (WNoC) proposades fins ara s'han centrat en aprofitar l'avantatge en termes de latència d'aquest nou paradigma creant múltiples canals sense fils per interconnectar nuclis allunyats entre sí. Aquesta estratègia és efectiva per complementar a NoCs clàssiques en escales mitjanes, però és probable que altres tecnologies com la nanofotònica puguin jugar millor aquest paper a escales més grans. Aquesta tesi presenta el concepte de Broadcast-Oriented WNoC (BoWNoC), un nou enfoc que intenta rendibilitzar al màxim la inherent simplicitat, flexibilitat, i capacitats broadcast de la tecnologia sense fils integrant una antena i transmissor/receptor per cada nucli del processador. Aquest paradigma forma part d'una visió més àmplia on un BoWNoC serviria tràfic broadcast i urgent, mentre que una xarxa convencional serviria fluxos de dades més pesats. En virtut de la escalabilitat i del seu suport broadcast, BoWNoC podria convertir-se en un element clau en una gran varietat d'arquitectures i algoritmes poc convencionals que milloressin considerablement el rendiment, l'eficiència, l'escalabilitat i la programabilitat de processadors amb molts nuclis. El present treball té com a objectius no només estudiar els aspectes fonamentals del paradigma BoWNoC, sinó també demostrar la seva viabilitat des dels punts de vista de la implementació, i del disseny de xarxa i arquitectura. Una exploració a la capa física valida la viabilitat de l'enfoc usant tecnologies longituds d'ona milimètriques en un futur proper, i suggereix l'ús d'antenes de grafè a la banda dels terahertz ja a més llarg termini. A capa d'enllaç, la tesi aporta una anàlisi del context de l'aplicació que és, més tard, utilitzada per al disseny d'un protocol d'accés al medi que permet servir tràfic broadcast a baixa latència i de forma fiable. A capa de xarxa, la nostra visió híbrida és avaluada posant èmfasi en la flexibilitat que aporta el fet de prendre les decisions a nivell de la interfície de xarxa, mostrant grans millores de rendiment per una àmplia selecció de patrons de tràfic. A nivell d'arquitectura, l'impacte que el concepte de BoWNoC pot tenir sobre el disseny de processadors amb molts nuclis no només és debatut de forma qualitativa i genèrica, sinó també avaluat quantitativament per una arquitectura concreta enfocada a la sincronització. Els resultats demostren que l'impacte de BoWNoC pot anar més enllà d'una millora en termes de rendiment de xarxa; representant, possiblement, un canvi radical a l'era dels molts nuclisAward-winningPostprint (published version

Broadcast-oriented wireless network-on-chip : fundamentals and feasibility

Premi extraordinari doctorat UPC curs 2015-2016, àmbit Enginyeria de les TICRecent years have seen the emergence and ubiquitous adoption of Chip Multiprocessors (CMPs), which rely on the coordinated operation of multiple execution units or cores. Successive CMP generations integrate a larger number of cores seeking higher performance with a reasonable cost envelope. For this trend to continue, however, important scalability issues need to be solved at different levels of design. Scaling the interconnect fabric is a grand challenge by itself, as new Network-on-Chip (NoC) proposals need to overcome the performance hurdles found when dealing with the increasingly variable and heterogeneous communication demands of manycore processors. Fast and flexible NoC solutions are needed to prevent communication become a performance bottleneck, situation that would severely limit the design space at the architectural level and eventually lead to the use of software frameworks that are slow, inefficient, or less programmable. The emergence of novel interconnect technologies has opened the door to a plethora of new NoCs promising greater scalability and architectural flexibility. In particular, wireless on-chip communication has garnered considerable attention due to its inherent broadcast capabilities, low latency, and system-level simplicity. Most of the resulting Wireless Network-on-Chip (WNoC) proposals have set the focus on leveraging the latency advantage of this paradigm by creating multiple wireless channels to interconnect far-apart cores. This strategy is effective as the complement of wired NoCs at moderate scales, but is likely to be overshadowed at larger scales by technologies such as nanophotonics unless bandwidth is unrealistically improved. This dissertation presents the concept of Broadcast-Oriented Wireless Network-on-Chip (BoWNoC), a new approach that attempts to foster the inherent simplicity, flexibility, and broadcast capabilities of the wireless technology by integrating one on-chip antenna and transceiver per processor core. This paradigm is part of a broader hybrid vision where the BoWNoC serves latency-critical and broadcast traffic, tightly coupled to a wired plane oriented to large flows of data. By virtue of its scalable broadcast support, BoWNoC may become the key enabler of a wealth of unconventional hardware architectures and algorithmic approaches, eventually leading to a significant improvement of the performance, energy efficiency, scalability and programmability of manycore chips. The present work aims not only to lay the fundamentals of the BoWNoC paradigm, but also to demonstrate its viability from the electronic implementation, network design, and multiprocessor architecture perspectives. An exploration at the physical level of design validates the feasibility of the approach at millimeter-wave bands in the short term, and then suggests the use of graphene-based antennas in the terahertz band in the long term. At the link level, this thesis provides an insightful context analysis that is used, afterwards, to drive the design of a lightweight protocol that reliably serves broadcast traffic with substantial latency improvements over state-of-the-art NoCs. At the network level, our hybrid vision is evaluated putting emphasis on the flexibility provided at the network interface level, showing outstanding speedups for a wide set of traffic patterns. At the architecture level, the potential impact of the BoWNoC paradigm on the design of manycore chips is not only qualitatively discussed in general, but also quantitatively assessed in a particular architecture for fast synchronization. Results demonstrate that the impact of BoWNoC can go beyond simply improving the network performance, thereby representing a possible game changer in the manycore era.Avenços en el disseny de multiprocessadors han portat a una àmplia adopció dels Chip Multiprocessors (CMPs), que basen el seu potencial en la operació coordinada de múltiples nuclis de procés. Generacions successives han anat integrant més nuclis en la recerca d'alt rendiment amb un cost raonable. Per a que aquesta tendència continuï, però, cal resoldre importants problemes d'escalabilitat a diferents capes de disseny. Escalar la xarxa d'interconnexió és un gran repte en ell mateix, ja que les noves propostes de Networks-on-Chip (NoC) han de servir un tràfic eminentment variable i heterogeni dels processadors amb molts nuclis. Són necessàries solucions ràpides i flexibles per evitar que les comunicacions dins del xip es converteixin en el pròxim coll d'ampolla de rendiment, situació que limitaria en gran mesura l'espai de disseny a nivell d'arquitectura i portaria a l'ús d'arquitectures i models de programació lents, ineficients o poc programables. L'aparició de noves tecnologies d'interconnexió ha possibilitat la creació de NoCs més flexibles i escalables. En particular, la comunicació intra-xip sense fils ha despertat un interès considerable en virtut de les seva baixa latència, simplicitat, i bon rendiment amb tràfic broadcast. La majoria de les Wireless NoC (WNoC) proposades fins ara s'han centrat en aprofitar l'avantatge en termes de latència d'aquest nou paradigma creant múltiples canals sense fils per interconnectar nuclis allunyats entre sí. Aquesta estratègia és efectiva per complementar a NoCs clàssiques en escales mitjanes, però és probable que altres tecnologies com la nanofotònica puguin jugar millor aquest paper a escales més grans. Aquesta tesi presenta el concepte de Broadcast-Oriented WNoC (BoWNoC), un nou enfoc que intenta rendibilitzar al màxim la inherent simplicitat, flexibilitat, i capacitats broadcast de la tecnologia sense fils integrant una antena i transmissor/receptor per cada nucli del processador. Aquest paradigma forma part d'una visió més àmplia on un BoWNoC serviria tràfic broadcast i urgent, mentre que una xarxa convencional serviria fluxos de dades més pesats. En virtut de la escalabilitat i del seu suport broadcast, BoWNoC podria convertir-se en un element clau en una gran varietat d'arquitectures i algoritmes poc convencionals que milloressin considerablement el rendiment, l'eficiència, l'escalabilitat i la programabilitat de processadors amb molts nuclis. El present treball té com a objectius no només estudiar els aspectes fonamentals del paradigma BoWNoC, sinó també demostrar la seva viabilitat des dels punts de vista de la implementació, i del disseny de xarxa i arquitectura. Una exploració a la capa física valida la viabilitat de l'enfoc usant tecnologies longituds d'ona milimètriques en un futur proper, i suggereix l'ús d'antenes de grafè a la banda dels terahertz ja a més llarg termini. A capa d'enllaç, la tesi aporta una anàlisi del context de l'aplicació que és, més tard, utilitzada per al disseny d'un protocol d'accés al medi que permet servir tràfic broadcast a baixa latència i de forma fiable. A capa de xarxa, la nostra visió híbrida és avaluada posant èmfasi en la flexibilitat que aporta el fet de prendre les decisions a nivell de la interfície de xarxa, mostrant grans millores de rendiment per una àmplia selecció de patrons de tràfic. A nivell d'arquitectura, l'impacte que el concepte de BoWNoC pot tenir sobre el disseny de processadors amb molts nuclis no només és debatut de forma qualitativa i genèrica, sinó també avaluat quantitativament per una arquitectura concreta enfocada a la sincronització. Els resultats demostren que l'impacte de BoWNoC pot anar més enllà d'una millora en termes de rendiment de xarxa; representant, possiblement, un canvi radical a l'era dels molts nuclisAward-winningPostprint (published version

Channel modeling for diffusive molecular communication - a tutorial review

Molecular communication (MC) is a new communication engineering paradigm where molecules are employed as information carriers. MC systems are expected to enable new revolutionary applications such as sensing of target substances in biotechnology, smart drug delivery in medicine, and monitoring of oil pipelines or chemical reactors in industrial settings. As for any other kind of communication, simple yet sufficiently accurate channel models are needed for the design, analysis, and efficient operation of MC systems. In this paper, we provide a tutorial review on mathematical channel modeling for diffusive MC systems. The considered end-to-end MC channel models incorporate the effects of the release mechanism, the MC environment, and the reception mechanism on the observed information molecules. Thereby, the various existing models for the different components of an MC system are presented under a common framework and the underlying biological, chemical, and physical phenomena are discussed. Deterministic models characterizing the expected number of molecules observed at the receiver and statistical models characterizing the actual number of observed molecules are developed. In addition, we provide channel models for timevarying MC systems with moving transmitters and receivers, which are relevant for advanced applications such as smart drug delivery with mobile nanomachines. For complex scenarios, where simple MC channel models cannot be obtained from first principles, we investigate simulation-driven and experiment-driven channel models. Finally, we provide a detailed discussion of potential challenges, open research problems, and future directions in channel modeling for diffusive MC systems

Advances of Machine Learning in Materials Science: Ideas and Techniques

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution, with large database and repositories appearing everywhere. Traditionally, materials science is a trial-and-error field, in both the computational and experimental departments. With the advent of machine learning-based techniques, there has been a paradigm shift: materials can now be screened quickly using ML models and even generated based on materials with similar properties; ML has also quietly infiltrated many sub-disciplinary under materials science. However, ML remains relatively new to the field and is expanding its wing quickly. There are a plethora of readily-available big data architectures and abundance of ML models and software; The call to integrate all these elements in a comprehensive research procedure is becoming an important direction of material science research. In this review, we attempt to provide an introduction and reference of ML to materials scientists, covering as much as possible the commonly used methods and applications, and discussing the future possibilities.Comment: 80 pages; 22 figures. To be published in Frontiers of Physics, 18, xxxxx, (2023

Channel Modeling for Diffusive Molecular Communication - A Tutorial Review

Molecular communication (MC) is a new communication engineering paradigm where molecules are employed as information carriers. MC systems are expected to enable new revolutionary applications such as sensing of target substances in biotechnology, smart drug delivery in medicine, and monitoring of oil pipelines or chemical reactors in industrial settings. As for any other kind of communication, simple yet sufficiently accurate channel models are needed for the design, analysis, and efficient operation of MC systems. In this paper, we provide a tutorial review on mathematical channel modeling for diffusive MC systems. The considered end-to-end MC channel models incorporate the effects of the release mechanism, the MC environment, and the reception mechanism on the observed information molecules. Thereby, the various existing models for the different components of an MC system are presented under a common framework and the underlying biological, chemical, and physical phenomena are discussed. Deterministic models characterizing the expected number of molecules observed at the receiver and statistical models characterizing the actual number of observed molecules are developed. In addition, we provide channel models for time-varying MC systems with moving transmitters and receivers, which are relevant for advanced applications such as smart drug delivery with mobile nanomachines. For complex scenarios, where simple MC channel models cannot be obtained from first principles, we investigate simulation-driven and experimentally-driven channel models. Finally, we provide a detailed discussion of potential challenges, open research problems, and future directions in channel modeling for diffusive MC systems.Comment: 40 pages; 23 figures, 2 tables; this paper is submitted to the Proceedings of IEE

Cell Migration within 3D Microenvironments: an Integrative Perspective from the Membrane to the Nucleus

La migración celular es fundamental para la vida y el desarrollo. Desafortunadamente, la movilidad celular también está asociada con algunas de las principales causas de morbilidad y mortalidad, incluidos los trastornos inmunitarios, esqueléticos y cardiovasculares, así como la metástasis del cáncer. Las células dependen en su capacidad para percibir y responder a estímulos externos en muchos procesos fisiológicos y patológicos (p. ej., desarrollo embrionario, angiogénesis, reparación de tejidos y progresión tumoral). El objetivo global de esta tesis doctoral fue investigar la respuesta migratoria de células individuales a señales bioquímicas y biofísicas. En particular, el enfoque de esta investigación se centró en los mecanismos que permiten a las células percibir e internalizar señales bioquímicas y biofísicas y la influencia de estos estímulos en la respuesta migratoria de las células individuales.El primer estudio tuvo como objetivo establecer una metodología para facilitar la integración de estudios teóricos con datos experimentales. Al minimizar la intervención del usuario, el sistema propuesto basado en técnicas de optimización Bayesiana gestionó de manera eficiente la calibración de los modelos in silico, que de otro modo sería tediosa y propensa a errores. Posteriormente, se construyó un modelo in silico para investigar cómo los estímulos bioquímicos y biofísicos influyen en el movimiento celular en tres dimensiones. Este modelo computacional integró algunos de los principales actores que permiten a las células percibir y responder a señales externas, que pueden actuar a diferentes escalas e interactuar entre sí. Los resultados mostraron, por un lado, que las células cambian su comportamiento migratorio en función de la pendiente de los gradientes químicos y la concentración absoluta de factores químicos (por ejemplo, factores de crecimiento) a su alrededor. Por otro lado, estos resultados revelaron que la respuesta migratoria de las células a la rigidez y densidad de la matriz depende de su fenotipo. En general, la tesis destaca la dependencia de la migración celular tridimensional al fenotipo de las células (es decir, el tamaño de su núcleo, la deformabilidad del mismo) y las propiedades del microambiente circundante (por ejemplo, el perfil químico, la rigidez de la matriz, el confinamiento).Cell migration is fundamental for life and development. Unfortunately, cell motility is also associated with some of the leading causes of morbidity and mortality, including immune, skeletal, and cardiovascular disorders as well as cancer metastasis. Cells rely on their ability to perceive and respond to external stimuli in many physiological and pathological processes (e.g., embryonic development, angiogenesis, tissue repair, and tumor progression). The global objective of this doctoral thesis was to investigate the migratory response of individual cells to biochemical and biophysical cues. In particular, the focus of this research was on the mechanisms enabling cells to perceive and internalize biochemical and biophysical cues and the influence of these stimuli on the migratory response of individual cells. The first study aimed at establishing a methodology to facilitate the integration of theoretical studies with experimental data. By minimizing user intervention, the proposed framework based on Bayesian optimization techniques efficiently handled the otherwise tedious and error-prone calibration of in silico models. Afterward, an in silico model was built to investigate how biochemical and biophysical stimuli influence three-dimensional cell motion. This computational model integrated some of the main actors enabling cells to probe and respond to external cues, which may act at different scales and interact with each other. The results showed, on the one hand, that cells change their migratory behavior based on the slope of chemical gradients and the absolute concentration of chemical factors (e.g., growth factors) around them. On the other hand, these results revealed that cells’ migratory response to matrix stiffness and density depends on their phenotype. Overall, this thesis highlights the dependence of three-dimensional cell migration on both cells’ phenotype (i.e., nucleus size, deformability) and the properties of the surrounding microenvironment (e.g., chemical profile, matrix rigidity, confinement).<br /