The distribution of word matches between Markovian sequences with periodic boundary conditions

Word match counts have traditionally been proposed as an alignment-free measure of similarity for biological sequences. The D2 statistic, which simply counts the number of exact word matches between two sequences, is a useful test bed for developing rigorous mathematical results, which can then be extended to more biologically useful measures. The distributional properties of the D2 statistic under the null hypothesis of identically and independently distributed letters have been studied extensively, but no comprehensive study of the D2 distribution for biologically more realistic higher-order Markovian sequences exists. Here we derive exact formulas for the mean and variance of the D2 statistic for Markovian sequences of any order, and demonstrate through Monte Carlo simulations that the entire distribution is accurately characterized by a Pólya-Aeppli distribution for sequence lengths of biological interest. The approach is novel in that Markovian dependency is defined for sequences with periodic boundary conditions, and this enables exact analytic formulas for the mean and variance to be derived. We also carry out a preliminary comparison between the approximate D2 distribution computed with the theoretical mean and variance under a Markovian hypothesis and an empirical D2 distribution from the human genome

Helping Low-Income Families Manage Childhood Asthma: Solutions for Healthcare & Beyond

Asthma is the most common childhood chronic illness, affecting more than seven million children nationwide. Managing chronic illness in a child is challenging for any family. Among the challenges is constant fear of an acute episode, a complex regimen of medications given daily or many times each day, frequent changes in prescriptions or dosages, coordinating multiple healthcare providers, and helping a child have as "normal" and active a childhood as his/her condition allows. Low-income children of color bear a heavier asthma burden than their white or more affluent peers. Those low-income children who live in urban areas such as Baltimore, Chicago, Los Angeles, and New York are particularly vulnerable. Families with limited resources struggle to provide their children with asthma the support that these children need

Caregiver Burden and Perceived Health Competence when Caring for Family Members Diagnosed with Alzheimer’s Disease and Related Dementia

Purpose: To identify if there is a relationship between perceived health competence and burden of care of informal caregivers of family members with Alzheimer’s Disease and Related Dementia (ADRD). Methods: Informal caregivers 18 years and older who received services from the Alzheimer’s Resource of Alaska were invited to complete a survey. Conclusion: Findings indicate that there was a significant negative correlation between Perceived Health Competence and Burden of Care (N = 64, r = -.54, p <.001). Furthermore, the three subscales of the Modified Montgomery-Borgatta Caregiver Burden Scale: Relationship burden (r = -.29, p = .021), Objective burden (r = -.65, p = < .001) and Stress burden (r = -.41, p = .001) indicated that different types of burden affect informal caregivers’ health competence. Implications for practice: Based on the findings of this study, it is important to ensure that informal caregivers do have time for themselves as well as taking care of their own health needs. Nurse Practitioners can play an important role in early detection and prevention, with periodic screening to help identify current needs and to ensure optimal health for these informal caregivers

Cooking practices, air quality, and the acceptability of advanced cookstoves in Haryana, India: an exploratory study to inform large-scale interventions.

BackgroundIn India, approximately 66% of households rely on dung or woody biomass as fuels for cooking. These fuels are burned under inefficient conditions, leading to household air pollution (HAP) and exposure to smoke containing toxic substances. Large-scale intervention efforts need to be informed by careful piloting to address multiple methodological and sociocultural issues. This exploratory study provides preliminary data for such an exercise from Palwal District, Haryana, India.MethodsTraditional cooking practices were assessed through semi-structured interviews in participating households. Philips and Oorja, two brands of commercially available advanced cookstoves with small blowers to improve combustion, were deployed in these households. Concentrations of particulate matter (PM) with a diameter &lt;2.5 μm (PM2.5) and carbon monoxide (CO) related to traditional stove use were measured using real-time and integrated personal, microenvironmental samplers for optimizing protocols to evaluate exposure reduction. Qualitative data on acceptability of advanced stoves and objective measures of stove usage were also collected.ResultsTwenty-eight of the thirty-two participating households had outdoor primary cooking spaces. Twenty households had liquefied petroleum gas (LPG) but preferred traditional stoves as the cost of LPG was higher and because meals cooked on traditional stoves were perceived to taste better. Kitchen area concentrations and kitchen personal concentrations assessed during cooking events were very high, with respective mean PM2.5 concentrations of 468 and 718 µg/m3. Twenty-four hour outdoor concentrations averaged 400 µg/m3. Twenty-four hour personal CO concentrations ranged between 0.82 and 5.27 ppm. The Philips stove was used more often and for more hours than the Oorja.ConclusionsThe high PM and CO concentrations reinforce the need for interventions that reduce HAP exposure in the aforementioned community. Of the two stoves tested, participants expressed satisfaction with the Philips brand as it met the local criteria for usability. Further understanding of how the introduction of an advanced stove influences patterns of household energy use is needed. The preliminary data provided here would be useful for designing feasibility and/or pilot studies aimed at intervention efforts locally and nationally

INNOVATIONS AND SUSTAINABILITY ISSUES INVOLVED IN GREEN PROJECT MANAGEMENT

The paper describes the attempt made in the direction of innovative approach to management and sustainability of Green projects concept. Green project concept involved the practice of increasing the efficiency with which building use resources-energy, water, materials, while reducing building impact on human health and the environment. Atmosphere above the earth has suffered high degree of pollution from buildings in recent times resulting in destabilization of ecosystem and ozone layer depletion which culminates in global warming phenomenon. In order to curtail the effect of negative impact of building on human health and environment, the complete building life cycle from design to post construction period should be thoroughly monitored. To this end, this study attempt, to describe innovative approaches to a sustainable Green project development including the attendant sustainability issues