233 research outputs found

    Design and Evaluation of a Hardware System for Online Signal Processing within Mobile Brain-Computer Interfaces

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    Brain-Computer Interfaces (BCIs) sind innovative Systeme, die eine direkte Kommunikation zwischen dem Gehirn und externen Geräten ermöglichen. Diese Schnittstellen haben sich zu einer transformativen Lösung nicht nur für Menschen mit neurologischen Verletzungen entwickelt, sondern auch für ein breiteres Spektrum von Menschen, das sowohl medizinische als auch nicht-medizinische Anwendungen umfasst. In der Vergangenheit hat die Herausforderung, dass neurologische Verletzungen nach einer anfänglichen Erholungsphase statisch bleiben, die Forscher dazu veranlasst, innovative Wege zu beschreiten. Seit den 1970er Jahren stehen BCIs an vorderster Front dieser Bemühungen. Mit den Fortschritten in der Forschung haben sich die BCI-Anwendungen erweitert und zeigen ein großes Potenzial für eine Vielzahl von Anwendungen, auch für weniger stark eingeschränkte (zum Beispiel im Kontext von Hörelektronik) sowie völlig gesunde Menschen (zum Beispiel in der Unterhaltungsindustrie). Die Zukunft der BCI-Forschung hängt jedoch auch von der Verfügbarkeit zuverlässiger BCI-Hardware ab, die den Einsatz in der realen Welt gewährleistet. Das im Rahmen dieser Arbeit konzipierte und implementierte CereBridge-System stellt einen bedeutenden Fortschritt in der Brain-Computer-Interface-Technologie dar, da es die gesamte Hardware zur Erfassung und Verarbeitung von EEG-Signalen in ein mobiles System integriert. Die Architektur der Verarbeitungshardware basiert auf einem FPGA mit einem ARM Cortex-M3 innerhalb eines heterogenen ICs, was Flexibilität und Effizienz bei der EEG-Signalverarbeitung gewährleistet. Der modulare Aufbau des Systems, bestehend aus drei einzelnen Boards, gewährleistet die Anpassbarkeit an unterschiedliche Anforderungen. Das komplette System wird an der Kopfhaut befestigt, kann autonom arbeiten, benötigt keine externe Interaktion und wiegt einschließlich der 16-Kanal-EEG-Sensoren nur ca. 56 g. Der Fokus liegt auf voller Mobilität. Das vorgeschlagene anpassbare Datenflusskonzept erleichtert die Untersuchung und nahtlose Integration von Algorithmen und erhöht die Flexibilität des Systems. Dies wird auch durch die Möglichkeit unterstrichen, verschiedene Algorithmen auf EEG-Daten anzuwenden, um unterschiedliche Anwendungsziele zu erreichen. High-Level Synthesis (HLS) wurde verwendet, um die Algorithmen auf das FPGA zu portieren, was den Algorithmenentwicklungsprozess beschleunigt und eine schnelle Implementierung von Algorithmusvarianten ermöglicht. Evaluierungen haben gezeigt, dass das CereBridge-System in der Lage ist, die gesamte Signalverarbeitungskette zu integrieren, die für verschiedene BCI-Anwendungen erforderlich ist. Darüber hinaus kann es mit einer Batterie von mehr als 31 Stunden Dauerbetrieb betrieben werden, was es zu einer praktikablen Lösung für mobile Langzeit-EEG-Aufzeichnungen und reale BCI-Studien macht. Im Vergleich zu bestehenden Forschungsplattformen bietet das CereBridge-System eine bisher unerreichte Leistungsfähigkeit und Ausstattung für ein mobiles BCI. Es erfüllt nicht nur die relevanten Anforderungen an ein mobiles BCI-System, sondern ebnet auch den Weg für eine schnelle Übertragung von Algorithmen aus dem Labor in reale Anwendungen. Im Wesentlichen liefert diese Arbeit einen umfassenden Entwurf für die Entwicklung und Implementierung eines hochmodernen mobilen EEG-basierten BCI-Systems und setzt damit einen neuen Standard für BCI-Hardware, die in der Praxis eingesetzt werden kann.Brain-Computer Interfaces (BCIs) are innovative systems that enable direct communication between the brain and external devices. These interfaces have emerged as a transformative solution not only for individuals with neurological injuries, but also for a broader range of individuals, encompassing both medical and non-medical applications. Historically, the challenge of neurological injury being static after an initial recovery phase has driven researchers to explore innovative avenues. Since the 1970s, BCIs have been at one forefront of these efforts. As research has progressed, BCI applications have expanded, showing potential in a wide range of applications, including those for less severely disabled (e.g. in the context of hearing aids) and completely healthy individuals (e.g. entertainment industry). However, the future of BCI research also depends on the availability of reliable BCI hardware to ensure real-world application. The CereBridge system designed and implemented in this work represents a significant leap forward in brain-computer interface technology by integrating all EEG signal acquisition and processing hardware into a mobile system. The processing hardware architecture is centered around an FPGA with an ARM Cortex-M3 within a heterogeneous IC, ensuring flexibility and efficiency in EEG signal processing. The modular design of the system, consisting of three individual boards, ensures adaptability to different requirements. With a focus on full mobility, the complete system is mounted on the scalp, can operate autonomously, requires no external interaction, and weighs approximately 56g, including 16 channel EEG sensors. The proposed customizable dataflow concept facilitates the exploration and seamless integration of algorithms, increasing the flexibility of the system. This is further underscored by the ability to apply different algorithms to recorded EEG data to meet different application goals. High-Level Synthesis (HLS) was used to port algorithms to the FPGA, accelerating the algorithm development process and facilitating rapid implementation of algorithm variants. Evaluations have shown that the CereBridge system is capable of integrating the complete signal processing chain required for various BCI applications. Furthermore, it can operate continuously for more than 31 hours with a 1800mAh battery, making it a viable solution for long-term mobile EEG recording and real-world BCI studies. Compared to existing research platforms, the CereBridge system offers unprecedented performance and features for a mobile BCI. It not only meets the relevant requirements for a mobile BCI system, but also paves the way for the rapid transition of algorithms from the laboratory to real-world applications. In essence, this work provides a comprehensive blueprint for the development and implementation of a state-of-the-art mobile EEG-based BCI system, setting a new benchmark in BCI hardware for real-world applicability

    Comparative analysis of energy transfer mechanisms for neural implants

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    As neural implant technologies advance rapidly, a nuanced understanding of their powering mechanisms becomes indispensable, especially given the long-term biocompatibility risks like oxidative stress and inflammation, which can be aggravated by recurrent surgeries, including battery replacements. This review delves into a comprehensive analysis, starting with biocompatibility considerations for both energy storage units and transfer methods. The review focuses on four main mechanisms for powering neural implants: Electromagnetic, Acoustic, Optical, and Direct Connection to the Body. Among these, Electromagnetic Methods include techniques such as Near-Field Communication (RF). Acoustic methods using high-frequency ultrasound offer advantages in power transmission efficiency and multi-node interrogation capabilities. Optical methods, although still in early development, show promising energy transmission efficiencies using Near-Infrared (NIR) light while avoiding electromagnetic interference. Direct connections, while efficient, pose substantial safety risks, including infection and micromotion disturbances within neural tissue. The review employs key metrics such as specific absorption rate (SAR) and energy transfer efficiency for a nuanced evaluation of these methods. It also discusses recent innovations like the Sectored-Multi Ring Ultrasonic Transducer (S-MRUT), Stentrode, and Neural Dust. Ultimately, this review aims to help researchers, clinicians, and engineers better understand the challenges of and potentially create new solutions for powering neural implants

    Continuous Estimation of Smoking Lapse Risk from Noisy Wrist Sensor Data Using Sparse and Positive-Only Labels

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    Estimating the imminent risk of adverse health behaviors provides opportunities for developing effective behavioral intervention mechanisms to prevent the occurrence of the target behavior. One of the key goals is to find opportune moments for intervention by passively detecting the rising risk of an imminent adverse behavior. Significant progress in mobile health research and the ability to continuously sense internal and external states of individual health and behavior has paved the way for detecting diverse risk factors from mobile sensor data. The next frontier in this research is to account for the combined effects of these risk factors to produce a composite risk score of adverse behaviors using wearable sensors convenient for daily use. Developing a machine learning-based model for assessing the risk of smoking lapse in the natural environment faces significant outstanding challenges requiring the development of novel and unique methodologies for each of them. The first challenge is coming up with an accurate representation of noisy and incomplete sensor data to encode the present and historical influence of behavioral cues, mental states, and the interactions of individuals with their ever-changing environment. The next noteworthy challenge is the absence of confirmed negative labels of low-risk states and adequate precise annotations of high-risk states. Finally, the model should work on convenient wearable devices to facilitate widespread adoption in research and practice. In this dissertation, we develop methods that account for the multi-faceted nature of smoking lapse behavior to train and evaluate a machine learning model capable of estimating composite risk scores in the natural environment. We first develop mRisk, which combines the effects of various mHealth biomarkers such as stress, physical activity, and location history in producing the risk of smoking lapse using sequential deep neural networks. We propose an event-based encoding of sensor data to reduce the effect of noises and then present an approach to efficiently model the historical influence of recent and past sensor-derived contexts on the likelihood of smoking lapse. To circumvent the lack of confirmed negative labels (i.e., annotated low-risk moments) and only a few positive labels (i.e., sensor-based detection of smoking lapse corroborated by self-reports), we propose a new loss function to accurately optimize the models. We build the mRisk models using biomarker (stress, physical activity) streams derived from chest-worn sensors. Adapting the models to work with less invasive and more convenient wrist-based sensors requires adapting the biomarker detection models to work with wrist-worn sensor data. To that end, we develop robust stress and activity inference methodologies from noisy wrist-sensor data. We first propose CQP, which quantifies wrist-sensor collected PPG data quality. Next, we show that integrating CQP within the inference pipeline improves accuracy-yield trade-offs associated with stress detection from wrist-worn PPG sensors in the natural environment. mRisk also requires sensor-based precise detection of smoking events and confirmation through self-reports to extract positive labels. Hence, we develop rSmoke, an orientation-invariant smoking detection model that is robust to the variations in sensor data resulting from orientation switches in the field. We train the proposed mRisk risk estimation models using the wrist-based inferences of lapse risk factors. To evaluate the utility of the risk models, we simulate the delivery of intelligent smoking interventions to at-risk participants as informed by the composite risk scores. Our results demonstrate the envisaged impact of machine learning-based models operating on wrist-worn wearable sensor data to output continuous smoking lapse risk scores. The novel methodologies we propose throughout this dissertation help instigate a new frontier in smoking research that can potentially improve the smoking abstinence rate in participants willing to quit

    Artificial Intelligence for Cognitive Health Assessment: State-of-the-Art, Open Challenges and Future Directions

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    The subjectivity and inaccuracy of in-clinic Cognitive Health Assessments (CHA) have led many researchers to explore ways to automate the process to make it more objective and to facilitate the needs of the healthcare industry. Artificial Intelligence (AI) and machine learning (ML) have emerged as the most promising approaches to automate the CHA process. In this paper, we explore the background of CHA and delve into the extensive research recently undertaken in this domain to provide a comprehensive survey of the state-of-the-art. In particular, a careful selection of significant works published in the literature is reviewed to elaborate a range of enabling technologies and AI/ML techniques used for CHA, including conventional supervised and unsupervised machine learning, deep learning, reinforcement learning, natural language processing, and image processing techniques. Furthermore, we provide an overview of various means of data acquisition and the benchmark datasets. Finally, we discuss open issues and challenges in using AI and ML for CHA along with some possible solutions. In summary, this paper presents CHA tools, lists various data acquisition methods for CHA, provides technological advancements, presents the usage of AI for CHA, and open issues, challenges in the CHA domain. We hope this first-of-its-kind survey paper will significantly contribute to identifying research gaps in the complex and rapidly evolving interdisciplinary mental health field

    Behavior quantification as the missing link between fields: Tools for digital psychiatry and their role in the future of neurobiology

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    The great behavioral heterogeneity observed between individuals with the same psychiatric disorder and even within one individual over time complicates both clinical practice and biomedical research. However, modern technologies are an exciting opportunity to improve behavioral characterization. Existing psychiatry methods that are qualitative or unscalable, such as patient surveys or clinical interviews, can now be collected at a greater capacity and analyzed to produce new quantitative measures. Furthermore, recent capabilities for continuous collection of passive sensor streams, such as phone GPS or smartwatch accelerometer, open avenues of novel questioning that were previously entirely unrealistic. Their temporally dense nature enables a cohesive study of real-time neural and behavioral signals. To develop comprehensive neurobiological models of psychiatric disease, it will be critical to first develop strong methods for behavioral quantification. There is huge potential in what can theoretically be captured by current technologies, but this in itself presents a large computational challenge -- one that will necessitate new data processing tools, new machine learning techniques, and ultimately a shift in how interdisciplinary work is conducted. In my thesis, I detail research projects that take different perspectives on digital psychiatry, subsequently tying ideas together with a concluding discussion on the future of the field. I also provide software infrastructure where relevant, with extensive documentation. Major contributions include scientific arguments and proof of concept results for daily free-form audio journals as an underappreciated psychiatry research datatype, as well as novel stability theorems and pilot empirical success for a proposed multi-area recurrent neural network architecture.Comment: PhD thesis cop

    Induction of Hebbian associative plasticity through paired non-invasive brain stimulation of premotor-motor areas to elucidate the network's functional role

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    The ventral premotor cortex (PMv) is believed to play a pivotal role in a multitude of visuomotor behaviors, such as sensory-guided goal-directed visuomotor transformations, arbitrary visuomotor mapping, and hyper-learnt visuomotor associations underlying automatic imitative tendencies. All these functions are likely carried out through the copious projections connecting PMv to the primary motor cortex (M1). Yet, causal evidence investigating the functional relevance of the PMv-M1 network remains elusive and scarce. In the studies reported in this thesis we addressed this issue using a transcranial magnetic stimulation (TMS) protocol called cortico-cortical paired associative stimulation (ccPAS), which relies on multisite stimulation to induce Hebbian spike-timing dependent plasticity (STDP) by repeatedly stimulating the pathway connecting two target areas to manipulate their connectivity. Firstly, we show that ccPAS protocols informed by both short- and long-latency PMv-M1 interactions effectively modulate connectivity between the two nodes. Then, by pre-activating the network to apply ccPAS in a state-dependent manner, we were able to selectively target specific functional visuo-motor pathways, demonstrating the relevance of PMv-M1 connectivity to arbitrary visuomotor mapping. Subsequently, we addressed the PMv-to-M1 role in automatic imitation, and demonstrated that its connectivity manipulation has a corresponding impact on automatic imitative tendencies. Finally, by combining dual-coil TMS connectivity assessments and ccPAS in young and elderly individuals, we traced effective connectivity of premotor-motor networks and tested their plasticity and relevance to manual dexterity and force in healthy ageing. Our findings provide unprecedent causal evidence of the functional role of the PMv-to-M1 network in young and elderly individuals. The studies presented in this thesis suggest that ccPAS can effectively modulate the strength of connectivity between targeted areas, and coherently manipulate a networks’ behavioral output. Results open new research prospects into the causal role of cortico-cortical connectivity, and provide necessary information to the development of clinical interventions based on connectivity manipulation

    A compact dual-band implantable antenna for wireless biotelemetry in arteriovenous grafts

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    Arteriovenous grafts (AVGs) are indispensable life-saving implants for chronic kidney disease (CKD) patients undergoing hemodialysis. However, AVGs will often fail due to postoperative complications such as cellular accumulation termed restenosis, blood clots, and infections, which are dominant causes of morbidity and mortality. A new generation of hemodialysis implants equipped with biosensors and multi-band antennas for wireless power and telemetry systems that can detect specific pathological parameters and report AVGs’ patency would be transformative for CKD. Our study proposes a compact dual-band implantable antenna for hemodialysis monitoring applications. It operates in 1.4 GHz and 2.45 GHz for wireless power transfer and biotelemetry purposes. The miniaturized antenna with a current size of 5 × 5 × 0.635 mm 3 exhibits wide bandwidth (300 MHz at 1.4 GHz band and 380 MHz at 2.45 GHz band), along with good impedance matching at two resonance frequencies. In addition, simulations are performed separately in a three-layer homogenous phantom and a realistic human body model. Measurements of the proposed antenna are evaluated in minced pork. The measured results of the fabricated antenna prototype are closely harmonized with the simulation ones, and the effect of different proportions of fat tissue in pork mince was analyzed, to verify the sensitivity of the antenna to the contacting medium. The specific absorption rate (SAR) and link budget calculation are also analyzed. Finally, the wireless biotelemetry function of the proposed antenna is realized and visualized by adopting a pair of nRF24L01 wireless transceivers, and sustainable and stable wireless data transmission characteristics are shown at a high data rate of 2 Mbps with up to 20 cm transmission distance
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