Behavioural robustness and the distributed mechanisms hypothesis

A current challenge in neuroscience and systems biology is to better understand properties that allow organisms to exhibit and sustain appropriate behaviours despite the effects of perturbations (behavioural robustness). There are still significant theoretical difficulties in this endeavour, mainly due to the context-dependent nature of the problem. Biological robustness, in general, is considered in the literature as a property that emerges from the internal structure of organisms, rather than being a dynamical phenomenon involving agent-internal controls, the organism body, and the environment. Our hypothesis is that the capacity for behavioural robustness is rooted in dynamical processes that are distributed between agent ‘brain’, body, and environment, rather than warranted exclusively by organisms’ internal mechanisms. Distribution is operationally defined here based on perturbation analyses. Evolutionary Robotics (ER) techniques are used here to construct four computational models to study behavioural robustness from a systemic perspective. Dynamical systems theory provides the conceptual framework for these investigations. The first model evolves situated agents in a goalseeking scenario in the presence of neural noise perturbations. Results suggest that evolution implicitly selects neural systems that are noise-resistant during coupling behaviour by concentrating search in regions of the fitness landscape that retain functionality for goal approaching. The second model evolves situated, dynamically limited agents exhibiting minimalcognitive behaviour (categorization task). Results indicate a small but significant tendency toward better performance under most types of perturbations by agents showing further cognitivebehavioural dependency on their environments. The third model evolves experience-dependent robust behaviour in embodied, one-legged walking agents. Evidence suggests that robustness is rooted in both internal and external dynamics, but robust motion emerges always from the systemin-coupling. The fourth model implements a historically dependent, mobile-object tracking task under sensorimotor perturbations. Results indicate two different modes of distribution, one in which inner controls necessarily depend on a set of specific environmental factors to exhibit behaviour, then these controls will be more vulnerable to perturbations on that set, and another for which these factors are equally sufficient for behaviours. Vulnerability to perturbations depends on the particular distribution. In contrast to most existing approaches to the study of robustness, this thesis argues that behavioural robustness is better understood in the context of agent-environment dynamical couplings, not in terms of internal mechanisms. Such couplings, however, are not always the full determinants of robustness. Challenges and limitations of our approach are also identified for future studies

Variable weight neural networks and their applications on material surface and epilepsy seizure phase classifications

This paper presents a novel neural network having variable weights, which is able to improve its learning and generalization capabilities, to deal with classification problems. The variable weight neural network (VWNN) allows its weights to be changed in operation according to the characteristic of the network inputs so that it demonstrates the ability to adapt to different characteristics of input data resulting in better performance compared with ordinary neural networks with fixed weights. The effectiveness of the VWNN is tested with the consideration of two real-life applications. The first application is on the classification of materials using the data collected by a robot finger with tactile sensors sliding along the surface of a given material. The second application considers the classification of seizure phases of epilepsy (seizure-free, pre-seizure and seizure phases) using real clinical data. Comparisons are performed with some traditional classification methods including neural network, k-nearest neighbors and naive Bayes classification techniques. It is shown that the VWNN classifier outperforms the traditional methods in terms of classification accuracy and robustness property when input datais contaminated by noise

Inferring Geodesic Cerebrovascular Graphs: Image Processing, Topological Alignment and Biomarkers Extraction

A vectorial representation of the vascular network that embodies quantitative features - location, direction, scale, and bifurcations - has many potential neuro-vascular applications. Patient-specific models support computer-assisted surgical procedures in neurovascular interventions, while analyses on multiple subjects are essential for group-level studies on which clinical prediction and therapeutic inference ultimately depend. This first motivated the development of a variety of methods to segment the cerebrovascular system. Nonetheless, a number of limitations, ranging from data-driven inhomogeneities, the anatomical intra- and inter-subject variability, the lack of exhaustive ground-truth, the need for operator-dependent processing pipelines, and the highly non-linear vascular domain, still make the automatic inference of the cerebrovascular topology an open problem. In this thesis, brain vessels’ topology is inferred by focusing on their connectedness. With a novel framework, the brain vasculature is recovered from 3D angiographies by solving a connectivity-optimised anisotropic level-set over a voxel-wise tensor field representing the orientation of the underlying vasculature. Assuming vessels joining by minimal paths, a connectivity paradigm is formulated to automatically determine the vascular topology as an over-connected geodesic graph. Ultimately, deep-brain vascular structures are extracted with geodesic minimum spanning trees. The inferred topologies are then aligned with similar ones for labelling and propagating information over a non-linear vectorial domain, where the branching pattern of a set of vessels transcends a subject-specific quantized grid. Using a multi-source embedding of a vascular graph, the pairwise registration of topologies is performed with the state-of-the-art graph matching techniques employed in computer vision. Functional biomarkers are determined over the neurovascular graphs with two complementary approaches. Efficient approximations of blood flow and pressure drop account for autoregulation and compensation mechanisms in the whole network in presence of perturbations, using lumped-parameters analog-equivalents from clinical angiographies. Also, a localised NURBS-based parametrisation of bifurcations is introduced to model fluid-solid interactions by means of hemodynamic simulations using an isogeometric analysis framework, where both geometry and solution profile at the interface share the same homogeneous domain. Experimental results on synthetic and clinical angiographies validated the proposed formulations. Perspectives and future works are discussed for the group-wise alignment of cerebrovascular topologies over a population, towards defining cerebrovascular atlases, and for further topological optimisation strategies and risk prediction models for therapeutic inference. Most of the algorithms presented in this work are available as part of the open-source package VTrails

Fingerprint-based biometric recognition allied to fuzzy-neural feature classification.

The research investigates fingerprint recognition as one of the most reliable biometrics identification methods. An automatic identification process of humans-based on fingerprints requires the input fingerprint to be matched with a large number of fingerprints in a database. To reduce the search time and computational complexity, it is desirable to classify the database of fingerprints into an accurate and consistent manner so that the input fingerprint is matched only with a subset of the fingerprints in the database. In this regard, the research addressed fingerprint classification. The goal is to improve the accuracy and speed up of existing automatic fingerprint identification algorithms. The investigation is based on analysis of fingerprint characteristics and feature classification using neural network and fuzzy-neural classifiers.The methodology developed, is comprised of image processing, computation of a directional field image, singular-point detection, and feature vector encoding. The statistical distribution of feature vectors was analysed using SPSS. Three types of classifiers, namely, multi-layered perceptrons, radial basis function and fuzzy-neural methods were implemented. The developed classification systems were tested and evaluated on 4,000 fingerprint images on the NIST-4 database. For the five-class problem, classification accuracy of 96.2% for FNN, 96.07% for MLP and 84.54% for RBF was achieved, without any rejection. FNN and MLP classification results are significant in comparison with existing studies, which have been reviewed

Whole Brain Network Dynamics of Epileptic Seizures at Single Cell Resolution

Epileptic seizures are characterised by abnormal brain dynamics at multiple scales, engaging single neurons, neuronal ensembles and coarse brain regions. Key to understanding the cause of such emergent population dynamics, is capturing the collective behaviour of neuronal activity at multiple brain scales. In this thesis I make use of the larval zebrafish to capture single cell neuronal activity across the whole brain during epileptic seizures. Firstly, I make use of statistical physics methods to quantify the collective behaviour of single neuron dynamics during epileptic seizures. Here, I demonstrate a population mechanism through which single neuron dynamics organise into seizures: brain dynamics deviate from a phase transition. Secondly, I make use of single neuron network models to identify the synaptic mechanisms that actually cause this shift to occur. Here, I show that the density of neuronal connections in the network is key for driving generalised seizure dynamics. Interestingly, such changes also disrupt network response properties and flexible dynamics in brain networks, thus linking microscale neuronal changes with emergent brain dysfunction during seizures. Thirdly, I make use of non-linear causal inference methods to study the nature of the underlying neuronal interactions that enable seizures to occur. Here I show that seizures are driven by high synchrony but also by highly non-linear interactions between neurons. Interestingly, these non-linear signatures are filtered out at the macroscale, and therefore may represent a neuronal signature that could be used for microscale interventional strategies. This thesis demonstrates the utility of studying multi-scale dynamics in the larval zebrafish, to link neuronal activity at the microscale with emergent properties during seizures

Entrainment dynamics organised by global manifolds in a circadian pacemaker model

This is the final version. Available on open access from Frontiers Media via the DOI in this recordCircadian rhythms are established by the entrainment of our intrinsic body clock to periodic forcing signals provided by the external environment, primarily variation in light intensity across the day/night cycle. Loss of entrainment can cause a multitude of physiological difficulties associated with misalignment of circadian rhythms, including insomnia, excessive daytime sleepiness, gastrointestinal disturbances, and general malaise. This can occur after travel to different time zones, known as jet lag; when changing shift work patterns; or if the period of an individual’s body clock is too far from the 24-hour period of environmental cycles. We consider the loss of entrainment and the dynamics of re-entrainment in a two-dimensional variant of the Forger-Jewett-Kronauer model of the human circadian pacemaker forced by a 24-hour light/dark cycle. We explore the loss of entrainment by continuing bifurcations of one-to-one entrained orbits under variation of forcing parameters and the intrinsic clock period. We show that the severity of the loss of entrainment is dependent on the type of bifurcation inducing the change of stability of the entrained orbit, which is in turn dependent on the environmental light intensity. We further show that for certain perturbations, the model pblackicts a counter-intuitive rapid re-entrainment if the light intensity is sufficiently high. We explain this phenomenon via computation of invariant manifolds of fixed points of a 24-hour stroboscopic map and show how the manifolds organise re-entrainment times following transitions between day and night shift work.Medical Research Council (MRC)US-UK Fulbright CommissionEngineering and Physical Sciences Research Council (EPSRC)National Science Foundation (NSF

A Complexity Approach

“How can we understand the dynamics of procurement management?” An answer to this question has predominantly been explained by procurement management experiencing dissatisfaction with the status quo, where the procurement organisation was viewed from other entities in the company as an insignificant, reactive and an administrative part of the business. The potential, however, for the procurement organisation to be significant in the company was argued to be vast (Ammer 1989, Ellram & Carr 1994, Van Weele 2005). In order to change the situation of the procurement organisation, procurement management was informed that they should in gradual steps develop the procurement organisation towards more sophistication and significance (Reck & Long 1988) producing strategies that were aligned with the overall company strategy including the development of policies, procedures, systems, tools and processes (Cousins 2002, Cousins et al 2008). This process changed the perspective of the procurement organisation which among other things, allowed the procurement entity to contribute to the implementation of the concept of supply chain management (Freeman & Cavinato 1990). Ever since I first got familiar with the practices of procurement and its management, I have been puzzled by its complexity. At the same time, I have wondered about how the same space of complexity in the procurement management domain literature has explained the same practices by reductionism, smoothness and simplicity as just described

Complexity, Emergent Systems and Complex Biological Systems:\ud Complex Systems Theory and Biodynamics. [Edited book by I.C. Baianu, with listed contributors (2011)]

An overview is presented of System dynamics, the study of the behaviour of complex systems, Dynamical system in mathematics Dynamic programming in computer science and control theory, Complex systems biology, Neurodynamics and Psychodynamics.\u

Pattern breaking: a complex systems approach to psychedelic medicine

Recent research has demonstrated the potential of psychedelic therapy for mental health care. However, the psychological experience underlying its therapeutic effects remains poorly understood. This paper proposes a framework that suggests psychedelics act as destabilizers, both psychologically and neurophysiologically. Drawing on the ‘entropic brain’ hypothesis and the ‘RElaxed Beliefs Under pSychedelics’ model, this paper focuses on the richness of psychological experience. Through a complex systems theory perspective, we suggest that psychedelics destabilize fixed points or attractors, breaking reinforced patterns of thinking and behaving. Our approach explains how psychedelic-induced increases in brain entropy destabilize neurophysiological set points and lead to new conceptualizations of psychedelic psychotherapy. These insights have important implications for risk mitigation and treatment optimization in psychedelic medicine, both during the peak psychedelic experience and during the subacute period of potential recovery