On the performance of the hybridisation between migrating birds optimisation variants and differential evolution for large scale continuous problems

Migrating Birds Optimisation (mbo) is a nature-inspired approach which has been shown to be very effective when solving a variety of combinatorial optimisation problems. More recently, an adaptation of the algorithm has been proposed that enables it to deal with continuous search spaces. We extend this work in two ways.Firstly, a novel leader replacement strategy is proposed to counter the slow convergence of the existing mbo algorithms due to low selection pressure. Secondly, mbo is hybridised with adaptive neighbourhood operators borrowed from Differential Evolution (de) that promote exploration and exploitation. The new variants are tested on two sets of continuous large scale optimisation problems. Results show that mbo variants using adaptive, exploration-based operators outperform de on the cec benchmark suite with 1000variables. Further experiments on a second suite of 19 problems show that mbo variants outperform de on 90% of these test-cases

Advances in Artificial Intelligence: Models, Optimization, and Machine Learning

The present book contains all the articles accepted and published in the Special Issue “Advances in Artificial Intelligence: Models, Optimization, and Machine Learning” of the MDPI Mathematics journal, which covers a wide range of topics connected to the theory and applications of artificial intelligence and its subfields. These topics include, among others, deep learning and classic machine learning algorithms, neural modelling, architectures and learning algorithms, biologically inspired optimization algorithms, algorithms for autonomous driving, probabilistic models and Bayesian reasoning, intelligent agents and multiagent systems. We hope that the scientific results presented in this book will serve as valuable sources of documentation and inspiration for anyone willing to pursue research in artificial intelligence, machine learning and their widespread applications

Biochemical Testing

Clinical Correlation and Diagnosis highlights the improvements in methodological approaches for the purposes of disease diagnosis and health research. Chapters cover such topics as serum protein electrophoresis, urinary iodine measurement, blood collection tubes, semi-solid phase assay and advancement in analytical and bioanalytical techniques, and serological diagnostic tools for Zika virus, among other subjects. All these will not be possible without a proper laboratory management where this book also includes the Tissue Bank ATMP Production as a model. The chapters are expected to provide a new perspective in health science which may trigger a further exploration into the diagnostic and research field

Optimal sensor placement for sewer capacity risk management

2019 Spring.Includes bibliographical references.Complex linear assets, such as those found in transportation and utilities, are vital to economies, and in some cases, to public health. Wastewater collection systems in the United States are vital to both. Yet effective approaches to remediating failures in these systems remains an unresolved shortfall for system operators. This shortfall is evident in the estimated 850 billion gallons of untreated sewage that escapes combined sewer pipes each year (US EPA 2004a) and the estimated 40,000 sanitary sewer overflows and 400,000 backups of untreated sewage into basements (US EPA 2001). Failures in wastewater collection systems can be prevented if they can be detected in time to apply intervention strategies such as pipe maintenance, repair, or rehabilitation. This is the essence of a risk management process. The International Council on Systems Engineering recommends that risks be prioritized as a function of severity and occurrence and that criteria be established for acceptable and unacceptable risks (INCOSE 2007). A significant impediment to applying generally accepted risk models to wastewater collection systems is the difficulty of quantifying risk likelihoods. These difficulties stem from the size and complexity of the systems, the lack of data and statistics characterizing the distribution of risk, the high cost of evaluating even a small number of components, and the lack of methods to quantify risk. This research investigates new methods to assess risk likelihood of failure through a novel approach to placement of sensors in wastewater collection systems. The hypothesis is that iterative movement of water level sensors, directed by a specialized metaheuristic search technique, can improve the efficiency of discovering locations of unacceptable risk. An agent-based simulation is constructed to validate the performance of this technique along with testing its sensitivity to varying environments. The results demonstrated that a multi-phase search strategy, with a varying number of sensors deployed in each phase, could efficiently discover locations of unacceptable risk that could be managed via a perpetual monitoring, analysis, and remediation process. A number of promising well-defined future research opportunities also emerged from the performance of this research

Evolutionary Computation

This book presents several recent advances on Evolutionary Computation, specially evolution-based optimization methods and hybrid algorithms for several applications, from optimization and learning to pattern recognition and bioinformatics. This book also presents new algorithms based on several analogies and metafores, where one of them is based on philosophy, specifically on the philosophy of praxis and dialectics. In this book it is also presented interesting applications on bioinformatics, specially the use of particle swarms to discover gene expression patterns in DNA microarrays. Therefore, this book features representative work on the field of evolutionary computation and applied sciences. The intended audience is graduate, undergraduate, researchers, and anyone who wishes to become familiar with the latest research work on this field

Optimizing the planning of remote construction sites to minimize the consequences of explosive attacks

Remote construction sites, such as oil production facilities and military forward operating bases, are often located in hostile areas that are vulnerable to the threat of explosive attacks. These attacks produce devastating and far-reaching consequences. From 2011-2015, explosive attacks targeting facilities and infrastructure resulted in more than 45,000 casualties and $73 billion in direct economic losses worldwide. Furthermore, the post-traumatic stress disorder rate among victims of explosive attacks is reported to be as high as 40%. To minimize the consequences of explosive attacks, site layout planners of remote construction sites utilize three primary protection measures that are designed to: (i) increase the standoff distances between site facilities and the potential location of an explosive device; (ii) construct perimeter walls to mitigate blast loads on facilities; and (iii) harden facilities to withstand blast loads. The integration of these protection measures increases construction costs and they can be challenging to implement when site space is limited. Accordingly, designers need to identify an optimum combination of these protection measures that minimizes the aforementioned explosive attack consequences while minimizing site construction costs. The main goal of this research study is to develop novel models for optimizing the planning of remote construction sites that provide the capability of minimizing facility destruction levels and consequences resulting from explosive attacks. To accomplish this goal, the research objectives of this study are to: (1) develop an innovative blast effects assessment model capable of efficiently quantifying and visualizing blast effects on facilities behind blast walls; (2) develop an original multi-objective facility protection model for optimizing the site layout and selection of perimeter blast walls and building materials in order to minimize facility destruction levels from explosive attacks while minimizing site construction costs; and (3) develop a novel multi-objective optimization model for the layout and security planning of remote construction sites that provides the capability of simultaneously minimizing the consequences of an explosive attack and the construction costs of remote sites. The performance of the developed optimization models was analyzed using case studies of hypothetical remote construction sites. The results of analyzing these case studies illustrated the novel and distinctive capabilities of the developed models in enabling designers to search for and select optimum design configurations based on the mission of the remote construction site. These capabilities will result in the construction of cost-effective, secure sites that will reduce the risks to site personnel and facilities from the devastating effects of an explosive attack

Robust Model Predictive Control for Linear Parameter Varying Systems along with Exploration of its Application in Medical Mobile Robots

This thesis seeks to develop a robust model predictive controller (MPC) for Linear Parameter Varying (LPV) systems. LPV models based on input-output display are employed. We aim to improve robust MPC methods for LPV systems with an input-output display. This improvement will be examined from two perspectives. First, the system must be stable in conditions of uncertainty (in signal scheduling or due to disturbance) and perform well in both tracking and regulation problems. Secondly, the proposed method should be practical, i.e., it should have a reasonable computational load and not be conservative. Firstly, an interpolation approach is utilized to minimize the conservativeness of the MPC. The controller is calculated as a linear combination of a set of offline predefined control laws. The coefficients of these offline controllers are derived from a real-time optimization problem. The control gains are determined to ensure stability and increase the terminal set. Secondly, in order to test the system's robustness to external disturbances, a free control move was added to the control law. Also, a Recurrent Neural Network (RNN) algorithm is applied for online optimization, showing that this optimization method has better speed and accuracy than traditional algorithms. The proposed controller was compared with two methods (robust MPC and MPC with LPV model based on input-output) in reference tracking and disturbance rejection scenarios. It was shown that the proposed method works well in both parts. However, two other methods could not deal with the disturbance. Thirdly, a support vector machine was introduced to identify the input-output LPV model to estimate the output. The estimated model was compared with the actual nonlinear system outputs, and the identification was shown to be effective. As a consequence, the controller can accurately follow the reference. Finally, an interpolation-based MPC with free control moves is implemented for a wheeled mobile robot in a hospital setting, where an RNN solves the online optimization problem. The controller was compared with a robust MPC and MPC-LPV in reference tracking, disturbance rejection, online computational load, and region of attraction. The results indicate that our proposed method surpasses and can navigate quickly and reliably while avoiding obstacles

Deriving Protein Structures Efficiently by Integrating Experimental Data into Biomolecular Simulations

Proteine sind molekulare Nanomaschinen in biologischen Zellen. Sie sind wesentliche Bausteine aller bekannten Lebensformen, von Einzellern bis hin zu Menschen, und erfüllen vielfältige Funktionen, wie beispielsweise den Sauerstofftransport im Blut oder als Bestandteil von Haaren. Störungen ihrer physiologischen Funktion können jedoch schwere degenerative Krankheiten wie Alzheimer und Parkinson verursachen. Die Entwicklung wirksamer Therapien für solche Proteinfehlfaltungserkrankungen erfordert ein tiefgreifendes Verständnis der molekularen Struktur und Dynamik von Proteinen. Da Proteine aufgrund ihrer lichtmikroskopisch nicht mehr auflösbaren Größe nur indirekt beobachtet werden können, sind experimentelle Strukturdaten meist uneindeutig. Dieses Problem lässt sich in silico mittels physikalischer Modellierung biomolekularer Dynamik lösen. In diesem Feld haben sich datengestützte Molekulardynamiksimulationen als neues Paradigma für das Zusammenfügen der einzelnen Datenbausteine zu einem schlüssigen Gesamtbild der enkodierten Proteinstruktur etabliert. Die Strukturdaten werden dabei als integraler Bestandteil in ein physikbasiertes Modell eingebunden. In dieser Arbeit untersuche ich, wie sogenannte strukturbasierte Modelle verwendet werden können, um mehrdeutige Strukturdaten zu komplementieren und die enthaltenen Informationen zu extrahieren. Diese Modelle liefern eine effiziente Beschreibung der aus der evolutionär optimierten nativen Struktur eines Proteins resultierenden Dynamik. Mithilfe meiner systematischen Simulationsmethode XSBM können biologische Kleinwinkelröntgenstreudaten mit möglichst geringem Rechenaufwand als physikalische Proteinstrukturen interpretiert werden. Die Funktionalität solcher datengestützten Methoden hängt stark von den verwendeten Simulationsparametern ab. Eine große Herausforderung besteht darin, experimentelle Informationen und theoretisches Wissen in geeigneter Weise relativ zueinander zu gewichten. In dieser Arbeit zeige ich, wie die entsprechenden Simulationsparameterräume mit Computational-Intelligence-Verfahren effizient erkundet und funktionale Parameter ausgewählt werden können, um die Leistungsfähigkeit komplexer physikbasierter Simulationstechniken zu optimieren. Ich präsentiere FLAPS, eine datengetriebene metaheuristische Optimierungsmethode zur vollautomatischen, reproduzierbaren Parametersuche für biomolekulare Simulationen. FLAPS ist ein adaptiver partikelschwarmbasierter Algorithmus inspiriert vom Verhalten natürlicher Vogel- und Fischschwärme, der das Problem der relativen Gewichtung verschiedener Kriterien in der multivariaten Optimierung generell lösen kann. Neben massiven Fortschritten in der Verwendung von künstlichen Intelligenzen zur Proteinstrukturvorhersage ermöglichen leistungsoptimierte datengestützte Simulationen detaillierte Einblicke in die komplexe Beziehung von biomolekularer Struktur, Dynamik und Funktion. Solche computergestützten Methoden können Zusammenhänge zwischen den einzelnen Puzzleteilen experimenteller Strukturinformationen herstellen und so unser Verständnis von Proteinen als den Grundbausteinen des Lebens vertiefen

Book of abstracts of the 10th International Chemical and Biological Engineering Conference: CHEMPOR 2008

This book contains the extended abstracts presented at the 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008, held in Braga, Portugal, over 3 days, from the 4th to the 6th of September, 2008. Previous editions took place in Lisboa (1975, 1889, 1998), Braga (1978), Póvoa de Varzim (1981), Coimbra (1985, 2005), Porto (1993), and Aveiro (2001). The conference was jointly organized by the University of Minho, “Ordem dos Engenheiros”, and the IBB - Institute for Biotechnology and Bioengineering with the usual support of the “Sociedade Portuguesa de Química” and, by the first time, of the “Sociedade Portuguesa de Biotecnologia”. Thirty years elapsed since CHEMPOR was held at the University of Minho, organized by T.R. Bott, D. Allen, A. Bridgwater, J.J.B. Romero, L.J.S. Soares and J.D.R.S. Pinheiro. We are fortunate to have Profs. Bott, Soares and Pinheiro in the Honor Committee of this 10th edition, under the high Patronage of his Excellency the President of the Portuguese Republic, Prof. Aníbal Cavaco Silva. The opening ceremony will confer Prof. Bott with a “Long Term Achievement” award acknowledging the important contribution Prof. Bott brought along more than 30 years to the development of the Chemical Engineering science, to the launch of CHEMPOR series and specially to the University of Minho. Prof. Bott’s inaugural lecture will address the importance of effective energy management in processing operations, particularly in the effectiveness of heat recovery and the associated reduction in greenhouse gas emission from combustion processes. The CHEMPOR series traditionally brings together both young and established researchers and end users to discuss recent developments in different areas of Chemical Engineering. The scope of this edition is broadening out by including the Biological Engineering research. One of the major core areas of the conference program is life quality, due to the importance that Chemical and Biological Engineering plays in this area. “Integration of Life Sciences & Engineering” and “Sustainable Process-Product Development through Green Chemistry” are two of the leading themes with papers addressing such important issues. This is complemented with additional leading themes including “Advancing the Chemical and Biological Engineering Fundamentals”, “Multi-Scale and/or Multi-Disciplinary Approach to Process-Product Innovation”, “Systematic Methods and Tools for Managing the Complexity”, and “Educating Chemical and Biological Engineers for Coming Challenges” which define the extended abstracts arrangements along this book. A total of 516 extended abstracts are included in the book, consisting of 7 invited lecturers, 15 keynote, 105 short oral presentations given in 5 parallel sessions, along with 6 slots for viewing 389 poster presentations. Full papers are jointly included in the companion Proceedings in CD-ROM. All papers have been reviewed and we are grateful to the members of scientific and organizing committees for their evaluations. It was an intensive task since 610 submitted abstracts from 45 countries were received. It has been an honor for us to contribute to setting up CHEMPOR 2008 during almost two years. We wish to thank the authors who have contributed to yield a high scientific standard to the program. We are thankful to the sponsors who have contributed decisively to this event. We also extend our gratefulness to all those who, through their dedicated efforts, have assisted us in this task. On behalf of the Scientific and Organizing Committees we wish you that together with an interesting reading, the scientific program and the social moments organized will be memorable for all.Fundação para a Ciência e a Tecnologia (FCT

Green Technologies for Production Processes

This book focuses on original research works about Green Technologies for Production Processes, including discrete production processes and process production processes, from various aspects that tackle product, process, and system issues in production. The aim is to report the state-of-the-art on relevant research topics and highlight the barriers, challenges, and opportunities we are facing. This book includes 22 research papers and involves energy-saving and waste reduction in production processes, design and manufacturing of green products, low carbon manufacturing and remanufacturing, management and policy for sustainable production, technologies of mitigating CO2 emissions, and other green technologies