Challenges and advanced concepts for the assessment of learning and memory function in mice

The mechanisms underlying the formation and retrieval of memories are still an active area of research and discussion. Manifold models have been proposed and refined over the years, with most assuming a dichotomy between memory processes involving non-conscious and conscious mechanisms. Despite our incomplete understanding of the underlying mechanisms, tests of memory and learning count among the most performed behavioral experiments. Here, we will discuss available protocols for testing learning and memory using the example of the most prevalent animal species in research, the laboratory mouse. A wide range of protocols has been developed in mice to test, e.g., object recognition, spatial learning, procedural memory, sequential problem solving, operant- and fear conditioning, and social recognition. Those assays are carried out with individual subjects in apparatuses such as arenas and mazes, which allow for a high degree of standardization across laboratories and straightforward data interpretation but are not without caveats and limitations. In animal research, there is growing concern about the translatability of study results and animal welfare, leading to novel approaches beyond established protocols. Here, we present some of the more recent developments and more advanced concepts in learning and memory testing, such as multi-step sequential lockboxes, assays involving groups of animals, as well as home cage-based assays supported by automated tracking solutions; and weight their potential and limitations against those of established paradigms. Shifting the focus of learning tests from the classical experimental chamber to settings which are more natural for rodents comes with a new set of challenges for behavioral researchers, but also offers the opportunity to understand memory formation and retrieval in a more conclusive way than has been attainable with conventional test protocols. We predict and embrace an increase in studies relying on methods involving a higher degree of automatization, more naturalistic- and home cage-based experimental setting as well as more integrated learning tasks in the future. We are confident these trends are suited to alleviate the burden on animal subjects and improve study designs in memory research

The Impact of Occupational Safety on Logistics and Automation in Industrial Plants

Research on workplace health and safety analyses the integration of work practices with safety, health and wealth of people at work. The aim of occupational safety is to realize a safe and health work environment, eliminating or reducing the risks for workers' safety and health. The objective of this thesis is the study, integration, development and application of innovative approaches and models for decision-making support in the context of occupational safety in industrial plants and logistics. Such methodologies are expected to lead practitioners and decision-makers, in particular safety professionals and companies, in the management of occupational safety. In particular, this research focuses on the integration and application of ergonomics principles to reduce biomechanical overload of manual work, and methodologies and solutions to improve safety of confined space work in industrial plants. The study of biomechanical overload due to manual handling of loads and awkward postures is the object of several researches and publications addressing the ergonomic risk assessment and the ergonomic approach to remove or reduce the risk of manual handling injuries and disorders. Furthermore, when awkward postures are assumed in high-risk workplaces as confined spaces, the overall risk of work is extremely high. Confined space work is a high-risk activity, posing a significant hazard for both workers and rescuers involved in the emergency response. The leading cause of accidents and fatalities in confined spaces is atmospheric condition (Sahli & Armstrong 1992, Harris et al. 2005, Flynn & Susi, 2010, Meeker, Susi & Flynn 2010, Ye 2011, Bellamy 2015). Further common causes are fire, explosion, ignition of flammable contaminants, spontaneous combustion and contact with temperature extremes. Besides, work activities in confined spaces (e.g., welding and maintenance tasks) frequently require awkward and static postures, at high temperatures. This thesis stresses the importance of implementing health and safety interventions at workplace. These interventions have impact not only on enterprise level but also on individual and social levels. Furthermore, protection of human life is a matter of human rights and human life has an invaluable value. In this thesis, the role of occupational safety and safety strategy as means for the improvement of workers and companies’ performances clearly emerges. Two parallel research fields on occupational safety are investigated: ergonomics and confined spaces. Selected data are introduced related to occupational accidents and diseases due to biomechanical overload and work in confined spaces. The literature survey on controls for risk elimination and reduction shows that technology for safety is available. Nevertheless, injuries and accidents still occur, i.e. safety is frequently considered an expensive investment and a compliance obligation. Specifically, administrative and engineering controls for risk elimination and reduction are introduced for each research field. Administrative controls include work procedures and mathematical models for the design of safe work processes. Such control methods reduce the workers' exposure to occupational risk factors. The ergonomic analysis of manual handling activities drives the modelling by multi-objective optimisation problems in the design of administrative controls for the ergonomic risk reduction in different industries. Administrative controls for risks in confined spaces include work procedures, a multi-criteria decision tool and the analysis of the requirements of Internet of Things (IOT) technologies for reducing the risk of confined space work. The introduction of automation to replace manual work and engineering controls for confined space work are analysed for the risk elimination. Results show that the integration of ergonomics and safety principles in the industrial processes plays a leading role in the successful implementation of the overall strategy. Technologies for safe confined space work and technical solutions assisting workers during manual material handling tasks have been the focus of the Solutions Database Project, funded by the Azienda Unità Sanitaria Locale of Bologna (AUSL), Italy. The study of such technological and technical solutions lead to the development of the Solutions Database, a free access database available online for researchers and practitioners (http://safetyengineering.din.unibo.it/en/banca-delle-soluzioni). The thesis ends with the recommendation that companies should integrate workplace health and safety principles to human resource management and work organisation. The management of health and safety issues should be considered to be crucial for workplace development, as a lever to increase performance and productivity. Finally, this research aims to support and reinforce the evolution of the concept of safety in industry, from ex post required obligation, to ex ante optimisation strategy

Measuring Behavior 2018 Conference Proceedings

These proceedings contain the papers presented at Measuring Behavior 2018, the 11th International Conference on Methods and Techniques in Behavioral Research. The conference was organised by Manchester Metropolitan University, in collaboration with Noldus Information Technology. The conference was held during June 5th – 8th, 2018 in Manchester, UK. Building on the format that has emerged from previous meetings, we hosted a fascinating program about a wide variety of methodological aspects of the behavioral sciences. We had scientific presentations scheduled into seven general oral sessions and fifteen symposia, which covered a topical spread from rodent to human behavior. We had fourteen demonstrations, in which academics and companies demonstrated their latest prototypes. The scientific program also contained three workshops, one tutorial and a number of scientific discussion sessions. We also had scientific tours of our facilities at Manchester Metropolitan Univeristy, and the nearby British Cycling Velodrome. We hope this proceedings caters for many of your interests and we look forward to seeing and hearing more of your contributions

DRONE DELIVERY OF CBNRECy – DEW WEAPONS Emerging Threats of Mini-Weapons of Mass Destruction and Disruption (WMDD)

Drone Delivery of CBNRECy – DEW Weapons: Emerging Threats of Mini-Weapons of Mass Destruction and Disruption (WMDD) is our sixth textbook in a series covering the world of UASs and UUVs. Our textbook takes on a whole new purview for UAS / CUAS/ UUV (drones) – how they can be used to deploy Weapons of Mass Destruction and Deception against CBRNE and civilian targets of opportunity. We are concerned with the future use of these inexpensive devices and their availability to maleficent actors. Our work suggests that UASs in air and underwater UUVs will be the future of military and civilian terrorist operations. UAS / UUVs can deliver a huge punch for a low investment and minimize human casualties.https://newprairiepress.org/ebooks/1046/thumbnail.jp

Implementation of Sensors and Artificial Intelligence for Environmental Hazards Assessment in Urban, Agriculture and Forestry Systems

The implementation of artificial intelligence (AI), together with robotics, sensors, sensor networks, Internet of Things (IoT), and machine/deep learning modeling, has reached the forefront of research activities, moving towards the goal of increasing the efficiency in a multitude of applications and purposes related to environmental sciences. The development and deployment of AI tools requires specific considerations, approaches, and methodologies for their effective and accurate applications. This Special Issue focused on the applications of AI to environmental systems related to hazard assessment in urban, agriculture, and forestry areas

The Largest Unethical Medical Experiment in Human History

This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants. The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated. Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment