305 research outputs found

    Independent component analysis for naive bayes classification

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    Ph.DDOCTOR OF PHILOSOPH

    Evaluating Microarray-based Classifiers: An Overview

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    For the last eight years, microarray-based class prediction has been the subject of numerous publications in medicine, bioinformatics and statistics journals. However, in many articles, the assessment of classification accuracy is carried out using suboptimal procedures and is not paid much attention. In this paper, we carefully review various statistical aspects of classifier evaluation and validation from a practical point of view. The main topics addressed are accuracy measures, error rate estimation procedures, variable selection, choice of classifiers and validation strategy

    Parameter clustering in Bayesian functional principal component analysis of neuroscientific data

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    The extraordinary advancements in neuroscientific technology for brain recordings over the last decades have led to increasingly complex spatiotemporal data sets. To reduce oversimplifications, new models have been developed to be able to identify meaningful patterns and new insights within a highly demanding data environment. To this extent, we propose a new model called parameter clustering functional principal component analysis (PCl-fPCA) that merges ideas from functional data analysis and Bayesian nonparametrics to obtain a flexible and computationally feasible signal reconstruction and exploration of spatiotemporal neuroscientific data. In particular, we use a Dirichlet process Gaussian mixture model to cluster functional principal component scores within the standard Bayesian functional PCA framework. This approach captures the spatial dependence structure among smoothed time series (curves) and its interaction with the time domain without imposing a prior spatial structure on the data. Moreover, by moving the mixture from data to functional principal component scores, we obtain a more general clustering procedure, thus allowing a higher level of intricate insight and understanding of the data. We present results from a simulation study showing improvements in curve and correlation reconstruction compared with different Bayesian and frequentist fPCA models and we apply our method to functional magnetic resonance imaging and electroencephalogram data analyses providing a rich exploration of the spatiotemporal dependence in brain time series.Publisher PDFPeer reviewe

    Parameter clustering in Bayesian functional PCA of neuroscientific data

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    The extraordinary advancements in neuroscientific technology for brain recordings over the last decades have led to increasingly complex spatiotemporal data sets. To reduce oversimplifications, new models have been developed to be able to identify meaningful patterns and new insights within a highly demanding data environment. To this extent, we propose a new model called parameter clustering functional principal component analysis (PCl-fPCA) that merges ideas from functional data analysis and Bayesian nonparametrics to obtain a flexible and computationally feasible signal reconstruction and exploration of spatiotemporal neuroscientific data. In particular, we use a Dirichlet process Gaussian mixture model to cluster functional principal component scores within the standard Bayesian functional PCA framework. This approach captures the spatial dependence structure among smoothed time series (curves) and its interaction with the time domain without imposing a prior spatial structure on the data. Moreover, by moving the mixture from data to functional principal component scores, we obtain a more general clustering procedure, thus allowing a higher level of intricate insight and understanding of the data. We present results from a simulation study showing improvements in curve and correlation reconstruction compared with different Bayesian and frequentist fPCA models and we apply our method to functional magnetic resonance imaging and electroencephalogram data analyses providing a rich exploration of the spatiotemporal dependence in brain time series.Publisher PDFPeer reviewe
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