Radiation therapy calculations using an on-demand virtual cluster via cloud computing

Computer hardware costs are the limiting factor in producing highly accurate radiation dose calculations on convenient time scales. Because of this, large-scale, full Monte Carlo simulations and other resource intensive algorithms are often considered infeasible for clinical settings. The emerging cloud computing paradigm promises to fundamentally alter the economics of such calculations by providing relatively cheap, on-demand, pay-as-you-go computing resources over the Internet. We believe that cloud computing will usher in a new era, in which very large scale calculations will be routinely performed by clinics and researchers using cloud-based resources. In this research, several proof-of-concept radiation therapy calculations were successfully performed on a cloud-based virtual Monte Carlo cluster. Performance evaluations were made of a distributed processing framework developed specifically for this project. The expected 1/n performance was observed with some caveats. The economics of cloud-based virtual computing clusters versus traditional in-house hardware is also discussed. For most situations, cloud computing can provide a substantial cost savings for distributed calculations.Comment: 12 pages, 4 figure

Charged hadron beam therapy : fast computational physics methods

Charged hadron beams have been investigated for use in radiation therapy of cancer since the 1940s due to their unique potential to place tightly conformal radiation doses deep inside tissue. This is achieved by exploiting the phenomenon of the so-called Bragg peak. In both research and clinical settings, fast and accurate radiation calculations play a crucial role in charged hadron therapy physics. Unfortunately, physicists are often faced with the fundamental trade off of speed versus accuracy in their calculations. This dissertation addresses this trade off by presenting three computational physics methods for specific and general charged hadron beam therapy calculations. In this dissertation the pseudo-Monte Carlo method of track repeating is adapted for fast calculations of linear energy transfer (LET) and for fast estimation of dose in the peripheral regions of the target volume (i.e. secondary dose estimation). Additionally, the first proof-of-concept framework for carrying out massively distributed parallel Monte Carlo calculations for radiation therapy using cloud computing is presented. Performance and accuracy assessments of each calculation method are also presented

First results from the LUCID-Timepix spacecraft payload onboard the TechDemoSat-1 satellite in Low Earth Orbit

The Langton Ultimate Cosmic ray Intensity Detector (LUCID) is a payload onboard the satellite TechDemoSat-1, used to study the radiation environment in Low Earth Orbit ($\sim$635km). LUCID operated from 2014 to 2017, collecting over 2.1 million frames of radiation data from its five Timepix detectors on board. LUCID is one of the first uses of the Timepix detector technology in open space, with the data providing useful insight into the performance of this technology in new environments. It provides high-sensitivity imaging measurements of the mixed radiation field, with a wide dynamic range in terms of spectral response, particle type and direction. The data has been analysed using computing resources provided by GridPP, with a new machine learning algorithm that uses the Tensorflow framework. This algorithm provides a new approach to processing Medipix data, using a training set of human labelled tracks, providing greater particle classification accuracy than other algorithms. For managing the LUCID data, we have developed an online platform called Timepix Analysis Platform at School (TAPAS). This provides a swift and simple way for users to analyse data that they collect using Timepix detectors from both LUCID and other experiments. We also present some possible future uses of the LUCID data and Medipix detectors in space.Comment: Accepted for publication in Advances in Space Researc

Virtual Reality Games for Motor Rehabilitation

This paper presents a fuzzy logic based method to track user satisfaction without the need for devices to monitor users physiological conditions. User satisfaction is the key to any product’s acceptance; computer applications and video games provide a unique opportunity to provide a tailored environment for each user to better suit their needs. We have implemented a non-adaptive fuzzy logic model of emotion, based on the emotional component of the Fuzzy Logic Adaptive Model of Emotion (FLAME) proposed by El-Nasr, to estimate player emotion in UnrealTournament 2004. In this paper we describe the implementation of this system and present the results of one of several play tests. Our research contradicts the current literature that suggests physiological measurements are needed. We show that it is possible to use a software only method to estimate user emotion

The impact of cellular characteristics on the evolution of shape homeostasis

The importance of individual cells in a developing multicellular organism is well known but precisely how the individual cellular characteristics of those cells collectively drive the emergence of robust, homeostatic structures is less well understood. For example cell communication via a diffusible factor allows for information to travel across large distances within the population, and cell polarisation makes it possible to form structures with a particular orientation, but how do these processes interact to produce a more robust and regulated structure? In this study we investigate the ability of cells with different cellular characteristics to grow and maintain homeostatic structures. We do this in the context of an individual-based model where cell behaviour is driven by an intra-cellular network that determines the cell phenotype. More precisely, we investigated evolution with 96 different permutations of our model, where cell motility, cell death, long-range growth factor (LGF), short-range growth factor (SGF) and cell polarisation were either present or absent. The results show that LGF has the largest positive impact on the fitness of the evolved solutions. SGF and polarisation also contribute, but all other capabilities essentially increase the search space, effectively making it more difficult to achieve a solution. By perturbing the evolved solutions, we found that they are highly robust to both mutations and wounding. In addition, we observed that by evolving solutions in more unstable environments they produce structures that were more robust and adaptive. In conclusion, our results suggest that robust collective behaviour is most likely to evolve when cells are endowed with long range communication, cell polarisation, and selection pressure from an unstable environment