Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common type of leukemia. The Cancer Genome Atlas Research Network has demonstrated the increasing genomic complexity of acute myeloid leukemia (AML). In addition, the network has facilitated our understanding of the molecular events leading to this deadly form of malignancy for which the prognosis has not improved over past decades. AML is a highly heterogeneous disease, and cytogenetics and molecular analysis of the various chromosome aberrations including deletions, duplications, aneuploidy, balanced reciprocal translocations and fusion of transcription factor genes and tyrosine kinases has led to better understanding and identification of subgroups of AML with different prognoses. Furthermore, molecular classification based on mRNA expression profiling has facilitated identification of novel subclasses and defined high-, poor-risk AML based on specific molecular signatures. However, despite increased understanding of AML genetics, the outcome for AML patients whose number is likely to rise as the population ages, has not changed significantly. Until it does, further investigation of the genomic complexity of the disease and advances in drug development are needed. In this review, leading AML clinicians and research investigators provide an up-to-date understanding of the molecular biology of the disease addressing advances in diagnosis, classification, prognostication and therapeutic strategies that may have significant promise and impact on overall patient survival

EUROPEAN CONFERENCE ON QUEUEING THEORY 2016

International audienceThis booklet contains the proceedings of the second European Conference in Queueing Theory (ECQT) that was held from the 18th to the 20th of July 2016 at the engineering school ENSEEIHT, Toulouse, France. ECQT is a biannual event where scientists and technicians in queueing theory and related areas get together to promote research, encourage interaction and exchange ideas. The spirit of the conference is to be a queueing event organized from within Europe, but open to participants from all over the world. The technical program of the 2016 edition consisted of 112 presentations organized in 29 sessions covering all trends in queueing theory, including the development of the theory, methodology advances, computational aspects and applications. Another exciting feature of ECQT2016 was the institution of the Takács Award for outstanding PhD thesis on "Queueing Theory and its Applications"

(Re-)Building Coalitions: The Role and Potential of Member States in Shaping the Future of the EU

Reforming the EU is hardly possible without coalitions of "builders" - member states willing and able to engage in sustainable coalition building at EU level. Since 2008, the EU and its members have found themselves in the middle of yet another formative phase. Will member states eventually succeed in shaping a Union able to guarantee the prosperity, security, and freedom of its citizens? This publication explores new patterns of member state interaction that emerged during recent crises and proposes ideas for strengthening coalition building at the EU level to encourage a sustained effort for EU reform by policymakers across Europe

The International Community and the CIS-7

The international community has sought to assist the development efforts of the CIS-7 countries since the collapse of the Soviet Union in the early 1990s. The international financial institutions have played a leading role in these efforts. Despite considerable engagement with the governments of these countries, overall progress has been disappointing. In this paper, we review the contribution of the international community to the transition challenge facing the CIS-7 countries and assess whether a change in strategy is warranted.CIS7, international financial institutions, policy reform, external debt

The International Community and the CIS-7

The international community has sought to assist the development efforts of the CIS-7 countries since the collapse of the Soviet Union in the early 1990s. The international financial institutions have played a leading role in these efforts. Despite considerable engagement with the govenments of these countries, overall progress has been disappointing. In this paper, we review the contribution of the international community to the transition challenge facing the CIS-7 countries and assess whether a change in strategy is warrented.

Business Groups and the Big Push: Meiji Japan's Mass Privatization and Subsequent Growth

Rosenstein-Rodan (1943) and others posit that rapid development requires a 'big push' -- the coordinated rapid growth of diverse complementary industries, and suggests a role for government in providing such coordination. We argue that Japan's zaibatsu, or pyramidal business groups, provided this coordination after the Meiji government failed at the task. We propose that pyramidal business groups are private sector mechanisms for coordinating and financing 'big push' growth, and that unique historical circumstances aided their success in prewar Japan. Specifically, Japan uniquely marginalized its feudal elite; withdrew its hand with a propitious mass privatization that rallied the private sector; marginalized an otherwise entrenched first generation of wealthy industrialists; and remained open to foreign trade and capital.