Incremental complexity of a bi-objective hypergraph transversal problem

The hypergraph transversal problem has been intensively studied, from both a theoretical and a practical point of view. In particular , its incremental complexity is known to be quasi-polynomial in general and polynomial for bounded hypergraphs. Recent applications in computational biology however require to solve a generalization of this problem, that we call bi-objective transversal problem. The instance is in this case composed of a pair of hypergraphs (A, B), and the aim is to find minimal sets which hit all the hyperedges of A while intersecting a minimal set of hyperedges of B. In this paper, we formalize this problem, link it to a problem on monotone boolean $\land$ -- $\lor$ formulae of depth 3 and study its incremental complexity

A Polynomial Delay Algorithm for Enumerating Minimal Dominating Sets in Chordal Graphs

An output-polynomial algorithm for the listing of minimal dominating sets in graphs is a challenging open problem and is known to be equivalent to the well-known Transversal problem which asks for an output-polynomial algorithm for listing the set of minimal hitting sets in hypergraphs. We give a polynomial delay algorithm to list the set of minimal dominating sets in chordal graphs, an important and well-studied graph class where such an algorithm was open for a while.Comment: 13 pages, 1 figure, submitte

Minimal dominating sets enumeration with FPT-delay parameterized by the degeneracy and maximum degree

At STOC 2002, Eiter, Gottlob, and Makino presented a technique called ordered generation that yields an $n^{O(d)}$-delay algorithm listing all minimal transversals of an $n$-vertex hypergraph of degeneracy $d$. Recently at IWOCA 2019, Conte, Kant\'e, Marino, and Uno asked whether this XP-delay algorithm parameterized by $d$ could be made FPT-delay parameterized by $d$ and the maximum degree $\Delta$, i.e., an algorithm with delay $f(d,\Delta)\cdot n^{O(1)}$ for some computable function $f$. Moreover, as a first step toward answering that question, they note that the same delay is open for the intimately related problem of listing all minimal dominating sets in graphs. In this paper, we answer the latter question in the affirmative.Comment: 18 pages, 2 figure

Computing knock out strategies in metabolic networks

Given a metabolic network in terms of its metabolites and reactions, our goal is to efficiently compute the minimal knock out sets of reactions required to block a given behaviour. We describe an algorithm which improves the computation of these knock out sets when the elementary modes (minimal functional subsystems) of the network are given. We also describe an algorithm which computes both the knock out sets and the elementary modes containing the blocked reactions directly from the description of the network and whose worst-case computational complexity is better than the algorithms currently in use for these problems. Computational results are included.Comment: 12 page