Integrated Development and Parallelization of Automated Dicentric Chromosome Identification Software to Expedite Biodosimetry Analysis

Manual cytogenetic biodosimetry lacks the ability to handle mass casualty events. We present an automated dicentric chromosome identification (ADCI) software utilizing parallel computing technology. A parallelization strategy combining data and task parallelism, as well as optimization of I/O operations, has been designed, implemented, and incorporated in ADCI. Experiments on an eight-core desktop show that our algorithm can expedite the process of ADCI by at least four folds. Experiments on Symmetric Computing, SHARCNET, Blue Gene/Q multi-processor computers demonstrate the capability of parallelized ADCI to process thousands of samples for cytogenetic biodosimetry in a few hours. This increase in speed underscores the effectiveness of parallelization in accelerating ADCI. Our software will be an important tool to handle the magnitude of mass casualty ionizing radiation events by expediting accurate detection of dicentric chromosomes

A model-based design flow for embedded vision applications on heterogeneous architectures

The ability to gather information from images is straightforward to human, and one of the principal input to understand external world. Computer vision (CV) is the process to extract such knowledge from the visual domain in an algorithmic fashion. The requested computational power to process these information is very high. Until recently, the only feasible way to meet non-functional requirements like performance was to develop custom hardware, which is costly, time-consuming and can not be reused in a general purpose. The recent introduction of low-power and low-cost heterogeneous embedded boards, in which CPUs are combine with heterogeneous accelerators like GPUs, DSPs and FPGAs, can combine the hardware efficiency needed for non-functional requirements with the flexibility of software development. Embedded vision is the term used to identify the application of the aforementioned CV algorithms applied in the embedded field, which usually requires to satisfy, other than functional requirements, also non-functional requirements such as real-time performance, power, and energy efficiency. Rapid prototyping, early algorithm parametrization, testing, and validation of complex embedded video applications for such heterogeneous architectures is a very challenging task. This thesis presents a comprehensive framework that: 1) Is based on a model-based paradigm. Differently from the standard approaches at the state of the art that require designers to manually model the algorithm in any programming language, the proposed approach allows for a rapid prototyping, algorithm validation and parametrization in a model-based design environment (i.e., Matlab/Simulink). The framework relies on a multi-level design and verification flow by which the high-level model is then semi-automatically refined towards the final automatic synthesis into the target hardware device. 2) Relies on a polyglot parallel programming model. The proposed model combines different programming languages and environments such as C/C++, OpenMP, PThreads, OpenVX, OpenCV, and CUDA to best exploit different levels of parallelism while guaranteeing a semi-automatic customization. 3) Optimizes the application performance and energy efficiency through a novel algorithm for the mapping and scheduling of the application 3 tasks on the heterogeneous computing elements of the device. Such an algorithm, called exclusive earliest finish time (XEFT), takes into consideration the possible multiple implementation of tasks for different computing elements (e.g., a task primitive for CPU and an equivalent parallel implementation for GPU). It introduces and takes advantage of the notion of exclusive overlap between primitives to improve the load balancing. This thesis is the result of three years of research activity, during which all the incremental steps made to compose the framework have been tested on real case studie

Scaling Robot Motion Planning to Multi-core Processors and the Cloud

Imagine a world in which robots safely interoperate with humans, gracefully and efficiently accomplishing everyday tasks. The robot's motions for these tasks, constrained by the design of the robot and task at hand, must avoid collisions with obstacles. Unfortunately, planning a constrained obstacle-free motion for a robot is computationally complex---often resulting in slow computation of inefficient motions. The methods in this dissertation speed up this motion plan computation with new algorithms and data structures that leverage readily available parallel processing, whether that processing power is on the robot or in the cloud, enabling robots to operate safer, more gracefully, and with improved efficiency. The contributions of this dissertation that enable faster motion planning are novel parallel lock-free algorithms, fast and concurrent nearest neighbor searching data structures, cache-aware operation, and split robot-cloud computation. Parallel lock-free algorithms avoid contention over shared data structures, resulting in empirical speedup proportional to the number of CPU cores working on the problem. Fast nearest neighbor data structures speed up searching in SO(3) and SE(3) metric spaces, which are needed for rigid body motion planning. Concurrent nearest neighbor data structures improve searching performance on metric spaces common to robot motion planning problems, while providing asymptotic wait-free concurrent operation. Cache-aware operation avoids long memory access times, allowing the algorithm to exhibit superlinear speedup. Split robot-cloud computation enables robots with low-power CPUs to react to changing environments by having the robot compute reactive paths in real-time from a set of motion plan options generated in a computationally intensive cloud-based algorithm. We demonstrate the scalability and effectiveness of our contributions in solving motion planning problems both in simulation and on physical robots of varying design and complexity. Problems include finding a solution to a complex motion planning problem, pre-computing motion plans that converge towards the optimal, and reactive interaction with dynamic environments. Robots include 2D holonomic robots, 3D rigid-body robots, a self-driving 1/10 scale car, articulated robot arms with and without mobile bases, and a small humanoid robot.Doctor of Philosoph

FPGA acceleration of the phylogenetic likelihood function for Bayesian MCMC inference methods

Background Likelihood (ML)-based phylogenetic inference has become a popular method for estimating the evolutionary relationships among species based on genomic sequence data. This method is used in applications such as RAxML, GARLI, MrBayes, PAML, and PAUP. The Phylogenetic Likelihood Function (PLF) is an important kernel computation for this method. The PLF consists of a loop with no conditional behavior or dependencies between iterations. As such it contains a high potential for exploiting parallelism using micro-architectural techniques. In this paper, we describe a technique for mapping the PLF and supporting logic onto a Field Programmable Gate Array (FPGA)-based co-processor. By leveraging the FPGA\u27s on-chip DSP modules and the high-bandwidth local memory attached to the FPGA, the resultant co-processor can accelerate ML-based methods and outperform state-of-the-art multi-core processors. Results We use the MrBayes 3 tool as a framework for designing our co-processor. For large datasets, we estimate that our accelerated MrBayes, if run on a current-generation FPGA, achieves a 10× speedup relative to software running on a state-of-the-art server-class microprocessor. The FPGA-based implementation achieves its performance by deeply pipelining the likelihood computations, performing multiple floating-point operations in parallel, and through a natural log approximation that is chosen specifically to leverage a deeply pipelined custom architecture. Conclusions Heterogeneous computing, which combines general-purpose processors with special-purpose co-processors such as FPGAs and GPUs, is a promising approach for high-performance phylogeny inference as shown by the growing body of literature in this field. FPGAs in particular are well-suited for this task because of their low power consumption as compared to many-core processors and Graphics Processor Units (GPUs)

Using reconfigurable computing technology to accelerate matrix decomposition and applications

Matrix decomposition plays an increasingly significant role in many scientific and engineering applications. Among numerous techniques, Singular Value Decomposition (SVD) and Eigenvalue Decomposition (EVD) are widely used as factorization tools to perform Principal Component Analysis for dimensionality reduction and pattern recognition in image processing, text mining and wireless communications, while QR Decomposition (QRD) and sparse LU Decomposition (LUD) are employed to solve the dense or sparse linear system of equations in bioinformatics, power system and computer vision. Matrix decompositions are computationally expensive and their sequential implementations often fail to meet the requirements of many time-sensitive applications. The emergence of reconfigurable computing has provided a flexible and low-cost opportunity to pursue high-performance parallel designs, and the use of FPGAs has shown promise in accelerating this class of computation. In this research, we have proposed and implemented several highly parallel FPGA-based architectures to accelerate matrix decompositions and their applications in data mining and signal processing. Specifically, in this dissertation we describe the following contributions: • We propose an efficient FPGA-based double-precision floating-point architecture for EVD, which can efficiently analyze large-scale matrices. • We implement a floating-point Hestenes-Jacobi architecture for SVD, which is capable of analyzing arbitrary sized matrices. • We introduce a novel deeply pipelined reconfigurable architecture for QRD, which can be dynamically configured to perform either Householder transformation or Givens rotation in a manner that takes advantage of the strengths of each. • We design a configurable architecture for sparse LUD that supports both symmetric and asymmetric sparse matrices with arbitrary sparsity patterns. • By further extending the proposed hardware solution for SVD, we parallelize a popular text mining tool-Latent Semantic Indexing with an FPGA-based architecture. • We present a configurable architecture to accelerate Homotopy l1-minimization, in which the modification of the proposed FPGA architecture for sparse LUD is used at its core to parallelize both Cholesky decomposition and rank-1 update. Our experimental results using an FPGA-based acceleration system indicate the efficiency of our proposed novel architectures, with application and dimension-dependent speedups over an optimized software implementation that range from 1.5ÃÂ to 43.6ÃÂ in terms of computation time

IMPROVING BWA-MEM WITH GPU PARALLEL COMPUTING

Due to the many advances made in designing algorithms, especially the ones used in bioinformatics, it is becoming harder and harder to improve their efficiencies. Therefore, hardware acceleration using General-Purpose computing on Graphics Processing Unit has become a popular choice. BWA-MEM is an important part of the BWA software package for sequence mapping. Because of its high speed and accuracy, we choose to parallelize the popular short DNA sequence mapper. BWA has been a prevalent single node tool in genome alignment, and it has been widely studied for acceleration for a long time since the first version of the BWA package came out. This thesis presents the Big Data GPGPU distributed BWA-MEM, a tool that combines GPGPU acceleration and distributed computing. The four hardware parallelization techniques used are CPU multi-threading, GPU paralleled, CPU distributed, and GPU distributed. The GPGPU distributed software typically outperforms other parallelization versions. The alignment is performed on a distributed network, and each node in the network executes a separate GPGPU paralleled version of the software. We parallelize the chain2aln function in three levels. In Level 1, the function ksw\_extend2, an algorithm based on Smith-Waterman, is parallelized to handle extension on one side of the seed. In Level 2, the function chain2aln is parallelized to handle chain extension, where all seeds within the same chain are extended. In Level 3, part of the function mem\_align1\_core is parallelized for extending multiple chains. Due to the program's complexity, the parallelization work was limited at the GPU version of ksw\_extend2 parallelization Level 3. However, we have successfully combined Spark with BWA-MEM and ksw\_extend2 at parallelization Level 1, which has shown that the proposed framework is possible. The paralleled Level 3 GPU version of ksw\_extend2 demonstrated noticeable speed improvement with the test data set

Neural Machine Translation Inspired Binary Code Similarity Comparison beyond Function Pairs

Binary code analysis allows analyzing binary code without having access to the corresponding source code. A binary, after disassembly, is expressed in an assembly language. This inspires us to approach binary analysis by leveraging ideas and techniques from Natural Language Processing (NLP), a rich area focused on processing text of various natural languages. We notice that binary code analysis and NLP share a lot of analogical topics, such as semantics extraction, summarization, and classification. This work utilizes these ideas to address two important code similarity comparison problems. (I) Given a pair of basic blocks for different instruction set architectures (ISAs), determining whether their semantics is similar or not; and (II) given a piece of code of interest, determining if it is contained in another piece of assembly code for a different ISA. The solutions to these two problems have many applications, such as cross-architecture vulnerability discovery and code plagiarism detection. We implement a prototype system INNEREYE and perform a comprehensive evaluation. A comparison between our approach and existing approaches to Problem I shows that our system outperforms them in terms of accuracy, efficiency and scalability. And the case studies utilizing the system demonstrate that our solution to Problem II is effective. Moreover, this research showcases how to apply ideas and techniques from NLP to large-scale binary code analysis.Comment: Accepted by Network and Distributed Systems Security (NDSS) Symposium 201

Virtualized Reconfigurable Resources and Their Secured Provision in an Untrusted Cloud Environment

The cloud computing business grows year after year. To keep up with increasing demand and to offer more services, data center providers are always searching for novel architectures. One of them are FPGAs, reconfigurable hardware with high compute power and energy efficiency. But some clients cannot make use of the remote processing capabilities. Not every involved party is trustworthy and the complex management software has potential security flaws. Hence, clients’ sensitive data or algorithms cannot be sufficiently protected. In this thesis state-of-the-art hardware, cloud and security concepts are analyzed and com- bined. On one side are reconfigurable virtual FPGAs. They are a flexible resource and fulfill the cloud characteristics at the price of security. But on the other side is a strong requirement for said security. To provide it, an immutable controller is embedded enabling a direct, confidential and secure transfer of clients’ configurations. This establishes a trustworthy compute space inside an untrusted cloud environment. Clients can securely transfer their sensitive data and algorithms without involving vulnerable software or a data center provider. This concept is implemented as a prototype. Based on it, necessary changes to current FPGAs are analyzed. To fully enable reconfigurable yet secure hardware in the cloud, a new hybrid architecture is required.Das Geschäft mit dem Cloud Computing wächst Jahr für Jahr. Um mit der steigenden Nachfrage mitzuhalten und neue Angebote zu bieten, sind Betreiber von Rechenzentren immer auf der Suche nach neuen Architekturen. Eine davon sind FPGAs, rekonfigurierbare Hardware mit hoher Rechenleistung und Energieeffizienz. Aber manche Kunden können die ausgelagerten Rechenkapazitäten nicht nutzen. Nicht alle Beteiligten sind vertrauenswürdig und die komplexe Verwaltungssoftware ist anfällig für Sicherheitslücken. Daher können die sensiblen Daten dieser Kunden nicht ausreichend geschützt werden. In dieser Arbeit werden modernste Hardware, Cloud und Sicherheitskonzept analysiert und kombiniert. Auf der einen Seite sind virtuelle FPGAs. Sie sind eine flexible Ressource und haben Cloud Charakteristiken zum Preis der Sicherheit. Aber auf der anderen Seite steht ein hohes Sicherheitsbedürfnis. Um dieses zu bieten ist ein unveränderlicher Controller eingebettet und ermöglicht eine direkte, vertrauliche und sichere Übertragung der Konfigurationen der Kunden. Das etabliert eine vertrauenswürdige Rechenumgebung in einer nicht vertrauenswürdigen Cloud Umgebung. Kunden können sicher ihre sensiblen Daten und Algorithmen übertragen ohne verwundbare Software zu nutzen oder den Betreiber des Rechenzentrums einzubeziehen. Dieses Konzept ist als Prototyp implementiert. Darauf basierend werden nötige Änderungen von modernen FPGAs analysiert. Um in vollem Umfang eine rekonfigurierbare aber dennoch sichere Hardware in der Cloud zu ermöglichen, wird eine neue hybride Architektur benötigt