High-Level Programming for Medical Imaging on Multi-GPU Systems Using the SkelCL Library

Application development for modern high-performance systems with Graphics Processing Units (GPUs) relies on low-level programming approaches like CUDA and OpenCL, which leads to complex, lengthy and error-prone programs. In this paper, we present SkelCL – a high-level programming model for systems with multiple GPUs and its implementation as a library on top of OpenCL. SkelCL provides three main enhancements to the OpenCL standard: 1) computations are conveniently expressed using parallel patterns (skeletons); 2) memory management is simplified using parallel container data types; 3) an automatic data (re)distribution mechanism allows for scalability when using multi-GPU systems. We use a real-world example from the field of medical imaging to motivate the design of our programming model and we show how application development using SkelCL is simplified without sacrificing performance: we were able to reduce the code size in our imaging example application by 50% while introducing only a moderate runtime overhead of less than 5%

Convolutional Dictionary Learning through Tensor Factorization

Tensor methods have emerged as a powerful paradigm for consistent learning of many latent variable models such as topic models, independent component analysis and dictionary learning. Model parameters are estimated via CP decomposition of the observed higher order input moments. However, in many domains, additional invariances such as shift invariances exist, enforced via models such as convolutional dictionary learning. In this paper, we develop novel tensor decomposition algorithms for parameter estimation of convolutional models. Our algorithm is based on the popular alternating least squares method, but with efficient projections onto the space of stacked circulant matrices. Our method is embarrassingly parallel and consists of simple operations such as fast Fourier transforms and matrix multiplications. Our algorithm converges to the dictionary much faster and more accurately compared to the alternating minimization over filters and activation maps

Novel high performance techniques for high definition computer aided tomography

Mención Internacional en el título de doctorMedical image processing is an interdisciplinary field in which multiple research areas are involved: image acquisition, scanner design, image reconstruction algorithms, visualization, etc. X-Ray Computed Tomography (CT) is a medical imaging modality based on the attenuation suffered by the X-rays as they pass through the body. Intrinsic differences in attenuation properties of bone, air, and soft tissue result in high-contrast images of anatomical structures. The main objective of CT is to obtain tomographic images from radiographs acquired using X-Ray scanners. The process of building a 3D image or volume from the 2D radiographs is known as reconstruction. One of the latest trends in CT is the reduction of the radiation dose delivered to patients through the decrease of the amount of acquired data. This reduction results in artefacts in the final images if conventional reconstruction methods are used, making it advisable to employ iterative reconstruction algorithms. There are numerous reconstruction algorithms available, from which we can highlight two specific types: traditional algorithms, which are fast but do not enable the obtaining of high quality images in situations of limited data; and iterative algorithms, slower but more reliable when traditional methods do not reach the quality standard requirements. One of the priorities of reconstruction is the obtaining of the final images in near real time, in order to reduce the time spent in diagnosis. To accomplish this objective, new high performance techniques and methods for accelerating these types of algorithms are needed. This thesis addresses the challenges of both traditional and iterative reconstruction algorithms, regarding acceleration and image quality. One common approach for accelerating these algorithms is the usage of shared-memory and heterogeneous architectures. In this thesis, we propose a novel simulation/reconstruction framework, namely FUX-Sim. This framework follows the hypothesis that the development of new flexible X-ray systems can benefit from computer simulations, which may also enable performance to be checked before expensive real systems are implemented. Its modular design abstracts the complexities of programming for accelerated devices to facilitate the development and evaluation of the different configurations and geometries available. In order to obtain near real execution times, low-level optimizations for the main components of the framework are provided for Graphics Processing Unit (GPU) architectures. Other alternative tackled in this thesis is the acceleration of iterative reconstruction algorithms by using distributed memory architectures. We present a novel architecture that unifies the two most important computing paradigms for scientific computing nowadays: High Performance Computing (HPC). The proposed architecture combines Big Data frameworks with the advantages of accelerated computing. The proposed methods presented in this thesis provide more flexible scanner configurations as they offer an accelerated solution. Regarding performance, our approach is as competitive as the solutions found in the literature. Additionally, we demonstrate that our solution scales with the size of the problem, enabling the reconstruction of high resolution images.El procesamiento de imágenes médicas es un campo interdisciplinario en el que participan múltiples áreas de investigación como la adquisición de imágenes, diseño de escáneres, algoritmos de reconstrucción de imágenes, visualización, etc. La tomografía computarizada (TC) de rayos X es una modalidad de imágen médica basada en el cálculo de la atenuación sufrida por los rayos X a medida que pasan por el cuerpo a escanear. Las diferencias intrínsecas en la atenuación de hueso, aire y tejido blando dan como resultado imágenes de alto contraste de estas estructuras anatómicas. El objetivo principal de la TC es obtener imágenes tomográficas a partir estas radiografías obtenidas mediante escáneres de rayos X. El proceso de construir una imagen o volumen en 3D a partir de las radiografías 2D se conoce como reconstrucción. Una de las últimas tendencias en la tomografía computarizada es la reducción de la dosis de radiación administrada a los pacientes a través de la reducción de la cantidad de datos adquiridos. Esta reducción da como resultado artefactos en las imágenes finales si se utilizan métodos de reconstrucción convencionales, por lo que es aconsejable emplear algoritmos de reconstrucción iterativos. Existen numerosos algoritmos de reconstrucción disponibles a partir de los cuales podemos destacar dos categorías: algoritmos tradicionales, rápidos pero no permiten obtener imágenes de alta calidad en situaciones en las que los datos son limitados; y algoritmos iterativos, más lentos pero más estables en situaciones donde los métodos tradicionales no alcanzan los requisitos en cuanto a la calidad de la imagen. Una de las prioridades de la reconstrucción es la obtención de las imágenes finales en tiempo casi real, con el fin de reducir el tiempo de diagnóstico. Para lograr este objetivo, se necesitan nuevas técnicas y métodos de alto rendimiento para acelerar estos algoritmos. Esta tesis aborda los desafíos de los algoritmos de reconstrucción tradicionales e iterativos, con respecto a la aceleración y la calidad de imagen. Un enfoque común para acelerar estos algoritmos es el uso de arquitecturas de memoria compartida y heterogéneas. En esta tesis, proponemos un nuevo sistema de simulación/reconstrucción, llamado FUX-Sim. Este sistema se construye alrededor de la hipótesis de que el desarrollo de nuevos sistemas de rayos X flexibles puede beneficiarse de las simulaciones por computador, en los que también se puede realizar un control del rendimiento de los nuevos sistemas a desarrollar antes de su implementación física. Su diseño modular abstrae las complejidades de la programación para aceleradores con el objetivo de facilitar el desarrollo y la evaluación de las diferentes configuraciones y geometrías disponibles. Para obtener ejecuciones en casi tiempo real, se proporcionan optimizaciones de bajo nivel para los componentes principales del sistema en las arquitecturas GPU. Otra alternativa abordada en esta tesis es la aceleración de los algoritmos de reconstrucción iterativa mediante el uso de arquitecturas de memoria distribuidas. Presentamos una arquitectura novedosa que unifica los dos paradigmas informáticos más importantes en la actualidad: computación de alto rendimiento (HPC) y Big Data. La arquitectura propuesta combina sistemas Big Data con las ventajas de los dispositivos aceleradores. Los métodos propuestos presentados en esta tesis proporcionan configuraciones de escáner más flexibles y ofrecen una solución acelerada. En cuanto al rendimiento, nuestro enfoque es tan competitivo como las soluciones encontradas en la literatura. Además, demostramos que nuestra solución escala con el tamaño del problema, lo que permite la reconstrucción de imágenes de alta resolución.This work has been mainly funded thanks to a FPU fellowship (FPU14/03875) from the Spanish Ministry of Education. It has also been partially supported by other grants: • DPI2016-79075-R. “Nuevos escenarios de tomografía por rayos X”, from the Spanish Ministry of Economy and Competitiveness. • TIN2016-79637-P Towards unification of HPC and Big Data Paradigms from the Spanish Ministry of Economy and Competitiveness. • Short-term scientific missions (STSM) grant from NESUS COST Action IC1305. • TIN2013-41350-P, Scalable Data Management Techniques for High-End Computing Systems from the Spanish Ministry of Economy and Competitiveness. • RTC-2014-3028-1 NECRA Nuevos escenarios clinicos con radiología avanzada from the Spanish Ministry of Economy and Competitiveness.Programa Oficial de Doctorado en Ciencia y Tecnología InformáticaPresidente: José Daniel García Sánchez.- Secretario: Katzlin Olcoz Herrero.- Vocal: Domenico Tali

Accelerated iterative image reconstruction for cone-beam computed tomography through Big Data frameworks

One of the latest trends in Computed Tomography (CT) is the reduction of the radiation dose delivered to patients through the decrease of the amount of acquired data. This reduction results in artifacts in the final images if conventional reconstruction methods are used, making it advisable to employ iterative algorithms to enhance image quality. Most approaches are built around two main operators, backprojection and projection, which are computationally expensive. In this work, we present an implementation of those operators for iterative reconstruction methods exploiting the Big Data paradigm. We define an architecture based on Apache Spark that supports both Graphical Processing Units (GPU) and CPU-based architectures. The aforementioned are parallelized using a partitioning scheme based on the division of the volume and irregular data structures in order to reduce the cost of communication and computation of the final images. Our solution accelerates the execution of the two most computational expensive components with Apache Spark, improving the programming experience of new iterative reconstruction algorithms and the maintainability of the source code increasing the level of abstraction for non-experienced high performance programmers. Through an experimental evaluation, we show that we can obtain results up to 10 faster for projection and 21 faster for backprojection when using a GPU-based cluster compared to a traditional multi-core version. Although a linear speed up was not reached, the proposed approach can be a good alternative for porting previous medical image reconstruction applications already implemented in C/C++ or even with CUDA or OpenCL programming models. Our solution enables the automatic detection of the GPU devices and execution on CPU and GPU tasks at the same time under the same system, using all the available resources.This work was supported by the NIH, United States under Grant R01-HL-098686 and Grant U01 EB018753, the Spanish Ministerio de Economia y Competitividad (projects TEC2013-47270-R, RTC-2014-3028 and TIN2016-79637-P), the Spanish Ministerio de Educacion (grant FPU14/03875), the Spanish Ministerio de Ciencia, Innovacion y Universidades (Instituto de Salud Carlos III, project DTS17/00122; Agencia Estatal de Investigacion, project DPI2016-79075-R-AEI/FEDER, UE), co-funded by European Regional Development Fund (ERDF), ‘‘A way of making Europe’’. The CNIC is supported by the Ministerio de Ciencia, Spain, Innovacion y Universidades, Spain and the Pro CNIC Foundation, Spain, and is a Severo Ochoa Center of Excellence, Spain (SEV-2015-0505). Finally, this research was partially supported by Madrid regional Government, Spain under the grant ’’Convergencia Big data-Hpc: de los sensores a las Aplicaciones. (CABAHLA-CM)’’. Ref: S2018/TCS-4423