1,131 research outputs found

    Forest planning utilizing high spatial resolution data

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    This thesis presents planning approaches adapted for high spatial resolution data from remote sensing and evaluate whether such approaches can enhance the provision of ecosystem services from forests. The presented methods are compared with conventional, stand-level methods. The main focus lies on the planning concept of dynamic treatment units (DTU), where treatments in small units for modelling ecosystem processes and forest management are clustered spatiotemporally to form treatment units realistic in practical forestry. The methodological foundation of the thesis is mainly airborne laser scanning data (raster cells 12.5x12.5 m2), different optimization methods and the forest decision support system Heureka. Paper I demonstrates a mixed-integer programming model for DTU planning, and the results highlight the economic advances of clustering harvests. Paper II and III presents an addition to a DTU heuristic from the literature and further evaluates its performance. Results show that direct modelling of fixed costs for harvest operations can improve plans and that DTU planning enhances the economic outcome of forestry. The higher spatial resolution of data in the DTU approach enables the planning model to assign management with higher precision than if stand-based planning is applied. Paper IV evaluates whether this phenomenon is also valid for ecological values. Here, an approach adapted for cell-level data is compared to a schematic approach, dealing with stand-level data, for the purpose of allocating retention patches. The evaluation of economic and ecological values indicate that high spatial resolution data and an adapted planning approach increased the ecological values, while differences in economy were small. In conclusion, the studies in this thesis demonstrate how forest planning can utilize high spatial resolution data from remote sensing, and the results suggest that there is a potential to increase the overall provision of ecosystem services if such methods are applied

    Integrating Experimental and Computational Approaches to Optimize 3D Bioprinting of Cancer Cells

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    A key feature distinguishing 3D bioprinting from other 3D cell culture techniques is its precise control over created structures. This property allows for the high-resolution fabrication of biomimetic structures with controlled structural and mechanical properties such as porosity, permeability, and stiffness. However, for bioprinting to be successful, a comprehensive understanding of cell behavior is essential, yet challenging. This includes the survivability of cells throughout the printing process, their interactions with the printed structures, and their responses to environmental cues after printing. There are numerous variables in bioprinting which influence the cell behavior, so bioprinting quality during and after the procedure. Thus, to achieve desirable results, it is necessary to consider and optimize these influential variables. So far, these optimizations have been accomplished primarily through trial and error and replicating several experiments, a procedure that is not only time-consuming but also costly. This issue motivated the development of computational techniques in the bioprinting process to more precisely predict and elucidate cells’ function within 3D printed structures during and after printing. During printing, we developed predictive machine learning models to determine the effect of different variables such as cell type, bioink formulation, printing settings parameters, and crosslinking condition on cell viability in extrusion-based bioprinting. To do this, we first created a dataset of these parameters for gelatin and alginate-based bioinks and the corresponding cell viability by integrating data obtained in our laboratory and those derived from the literature. Then, we developed regression and classification neural networks to predict cell viability based on these bioprinting variables. Compared to models that have been developed so far, the performance of our models was superior and showed great prediction results. The study further demonstrated that among the variables investigated in bioprinting, cell type, printing pressure, and crosslinker concentration, respectively, had the most significant impact on the survival of cells. Additionally, we introduced a new optimization strategy that employs the Bayesian optimization model based on the developed regression neural network to determine the optimal combination of the selected bioprinting parameters for maximizing cell viability and eliminating trial-and-error experiments. In our study, this strategy enabled us to identify the optimal crosslinking parameters, within a specified range, including those not previously explored, resulting in optimum cell viability. Finally, we experimentally validated the optimization model's performance. After printing, we developed a cellular automata model for the first time to predict and elucidate the post-printing cell behavior within the 3D bioprinted construct. To improve our model, we bioprinted a 3D construct using cell-laden hydrogel and evaluated cellular functions, including viability and proliferation, in 11 days. The results showed that our model successfully simulated the 3D bioprinted structure and captured in-vitro observations. The proposed model is beneficial for demonstrating complex cellular systems, including cellular proliferation, movement, cell interactions with the environment (e.g., extracellular microenvironment and neighboring cells), and cell aggregation within the scaffold. We also demonstrated that this computational model could predict post-printing biological functions for different initial cell numbers in bioink and different bioink formulations with gelatin and alginate without replicating several in-vitro measurements. Taken all together, this thesis introduces novel bioprinting process design strategies by presenting mathematical and computational frameworks for both during and after bioprinting. We believe such frameworks will substantially impact 3D bioprinting's future application and inspire researchers to further realize how computational methods might be utilized to advance in-vitro 3D bioprinting research

    Towards a muon collider

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    A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work

    2017 GREAT Day Program

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    SUNY Geneseo’s Eleventh Annual GREAT Day.https://knightscholar.geneseo.edu/program-2007/1011/thumbnail.jp

    Navigation of a compartmentalized robot system

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    After making progression in developing the fundamental problems related to single-robot control, many researchers swerved and diverged their focus to studying multi-robot coordination. This research aims to take the motion planning and control (MPC) problem of a multi-robot system into a new space by considering a compartmentalized robot. An efficient variant of globally rigid formation, in which multiple car-like units are adjoint and move in parallel without collisions. The motion is governed by one of the sub-units acting as a leader, while other units maintain the fixed distance amongst each other and the leader in a rigid formation. The minimum distance technique is an important input to facilitate collision avoidance, robot decision making, and robot navigation. In this study a novel method to analytically compute the minimum distance between the closest point on the line segments of rectangular protective region and the obstacle is presented. Utilizing the Lyapunov-based Control Scheme a set of autonomous controllers are designed. Computer simulations of the proposed Lyapunov-based controllers for the compartmentalized robot are presented in interesting scenarios to show the efficacy of the unique set of controllers. In these simulations, the compartmentalized robot shows strict maintenance of a rigid formation with efficient collision and obstacle avoidance. The results open up research in the design and implementation of controllers by considering multiple compartmentalized robots into swarm models, splitting and re-joining units, and applying rotational leadership ideas

    Hidden Citations Obscure True Impact in Science

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    References, the mechanism scientists rely on to signal previous knowledge, lately have turned into widely used and misused measures of scientific impact. Yet, when a discovery becomes common knowledge, citations suffer from obliteration by incorporation. This leads to the concept of hidden citation, representing a clear textual credit to a discovery without a reference to the publication embodying it. Here, we rely on unsupervised interpretable machine learning applied to the full text of each paper to systematically identify hidden citations. We find that for influential discoveries hidden citations outnumber citation counts, emerging regardless of publishing venue and discipline. We show that the prevalence of hidden citations is not driven by citation counts, but rather by the degree of the discourse on the topic within the text of the manuscripts, indicating that the more discussed is a discovery, the less visible it is to standard bibliometric analysis. Hidden citations indicate that bibliometric measures offer a limited perspective on quantifying the true impact of a discovery, raising the need to extract knowledge from the full text of the scientific corpus

    LIPIcs, Volume 261, ICALP 2023, Complete Volume

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    LIPIcs, Volume 261, ICALP 2023, Complete Volum

    2010 GREAT Day Program

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    SUNY Geneseo’s Fourth Annual GREAT Day. This file has a supplement of three additional pages, linked in this record.https://knightscholar.geneseo.edu/program-2007/1004/thumbnail.jp

    2014 GREAT Day Program

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    SUNY Geneseo’s Eighth Annual GREAT Day.https://knightscholar.geneseo.edu/program-2007/1008/thumbnail.jp
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