Project Final Report Use and Dissemination of Foreground

This document is the final report on use and dissemination of foreground, part of the CONNECT final report. The document provides the lists of: publications, dissemination activities, and exploitable foregroun

Reconfigurable component connectors

This thesis provides formal methods for reconfigurable component connectors.UBL - phd migration 201

Design of Approaches for Dependability and Initial Prototypes

The aim of CONNECT is to achieve universal interoperability between heterogeneous Networked Systems. For this, the non-functional properties required at each side of the connection going to be established must be fulfilled. By the one inclusive term "CONNECTability" we comprehend properties belonging to all four non-functional concerns of interest for CONNECT, namely dependability, performance, security and trust. We model such properties in conformance with a meta-model which establishes the relevant concepts and their relations. Then, building on the conceptual models proposed in the first year in Deliverable D5.1, in this document we present the approaches developed for assuring CONNECTability both at synthesis time and at runtime. The contributions include: the Dependability&Performance analysis Enabler, for which we release a modular architecture supporting stochastic verification and state-based analysis; incremental verification and event-based monitoring for runtime analysis; a model-based approach to interoperable trust management; the Security-by-Contract-with-Trust framework, which guarantees and enforces the expected trust levels and security policies

Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation.

BACKGROUND:Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 transcriptionally regulated genes are largely unknown. METHODS:In this study, we performed a global transcriptional analysis using gene array technology to investigate the transcriptional role of CDK11 in osteosarcoma. The promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay were used to identify direct transcriptional targets of CDK11. Clinical relevance and function of core-binding factor subunit beta (CBFβ) were further accessed in osteosarcoma. RESULTS:We identified a transcriptional role of protein-DNA interaction for CDK11p110, but not CDK11p58, in the regulation of CBFβ expression in osteosarcoma cells. The CBFβ promoter luciferase assay, chromatin immunoprecipitation assay, and Gel Shift assay confirmed that CBFβ is a direct transcriptional target of CDK11. High expression of CBFβ is associated with poor outcome in osteosarcoma patients. Expression of CBFβ contributes to the proliferation and metastatic behavior of osteosarcoma cells. CONCLUSIONS:These data establish CBFβ as a mediator of CDK11p110 dependent oncogenesis and suggest that targeting the CDK11- CBFβ pathway may be a promising therapeutic strategy for osteosarcoma treatment

Stochastic models for quality of service of component connectors

The intensifying need for scalable software has motivated modular development and using systems distributed over networks to implement large-scale applications. In Service-oriented Computing, distributed services are composed to provide large-scale services with a specific functionality. In this way, reusability of existing services can be increased. However, due to the heterogeneity of distributed software systems, software composition is not easy and requires additional mechanisms to impose some form of a coordination on a distributed software system. Besides functional correctness, a composed service must satisfy various quantitative requirements for its clients, which are generically called its quality of service (QoS). Particularly, it is tricky to obtain the overall QoS of a composed service even if the QoS information of its constituent distributed services is given. In this thesis, we propose Stochastic Reo to specify software composition with QoS aspects and its compositional semantic models. They are also used as intermediate models to generate their corresponding stochastic models for practical analysis. Based on this, we have implemented the tool Reo2MC. Using Reo2MC, we have modeled and analyzed an industrial software, the ASK system. Its analysis results provided the best cost-effective resource utilization and some suggestions to improve the performance of the system.UBL - phd migration 201

Software framework for the development of context-aware reconfigurable systems

In this project we propose a new software framework for the development of context-aware and secure controlling software of distributed reconfigurable systems. Context-awareness is a key feature allowing the adaptation of systems behaviour according to the changing environment. We introduce a new definition of the term “context” for reconfigurable systems then we define a new context modelling and reasoning approach. Afterwards, we define a meta-model of context-aware reconfigurable applications that paves the way to the proposed framework. The proposed framework has a three-layer architecture: reconfiguration, context control, and services layer, where each layer has its well-defined role. We define also a new secure conversation protocol between distributed trustless parts based on the blockchain technology as well as the elliptic curve cryptography. To get better correctness and deployment guarantees of applications models in early development stages, we propose a new UML profile called GR-UML to add new semantics allowing the modelling of probabilistic scenarios running under memory and energy constraints, then we propose a methodology using transformations between the GR-UML, the GR-TNCES Petri nets formalism, and the IEC 61499 function blocks. A software tool implementing the methodology concepts is developed. To show the suitability of the mentioned contributions two case studies (baggage handling system and microgrids) are considered.In diesem Projekt schlagen wir ein Framework für die Entwicklung von kontextbewussten, sicheren Anwendungen von verteilten rekonfigurierbaren Systemen vor. Kontextbewusstheit ist eine Schlüsseleigenschaft, die die Anpassung des Systemverhaltens an die sich ändernde Umgebung ermöglicht. Wir führen eine Definition des Begriffs ``Kontext" für rekonfigurierbare Systeme ein und definieren dann einen Kontextmodellierungs- und Reasoning-Ansatz. Danach definieren wir ein Metamodell für kontextbewusste rekonfigurierbare Anwendungen, das den Weg zum vorgeschlagenen Framework ebnet. Das Framework hat eine dreischichtige Architektur: Rekonfigurations-, Kontextkontroll- und Dienste-Schicht, wobei jede Schicht ihre wohldefinierte Rolle hat. Wir definieren auch ein sicheres Konversationsprotokoll zwischen verteilten Teilen, das auf der Blockchain-Technologie sowie der elliptischen Kurven-Kryptographie basiert. Um bessere Korrektheits- und Einsatzgarantien für Anwendungsmodelle zu erhalten, schlagen wir ein UML-Profil namens GR-UML vor, um Semantik umzufassen, die die Modellierung probabilistischer Szenarien unter Speicher- und Energiebeschränkungen ermöglicht. Dann schlagen wir eine Methodik vor, die Transformationen zwischen GR-UML, dem GR-TNCES-Petrinetz-Formalismus und den IEC 61499-Funktionsblöcken verwendet. Es wird ein Software entwickelt, das die Konzepte der Methodik implementiert. Um die Eignung der genannten Beiträge zu zeigen, werden zwei Fallstudien betrachtet