739,322 research outputs found
Multiway vortex valve system Patent
Multiple vortex amplifier system as fluid valv
A Novel Alcohol-Sensitive Site in the M3 Domain of the NMDA Receptor GluN2A Subunit
Accumulating studies have demonstrated that the N-methyl-D-aspartate receptor is one of the most important targets of ethanol in the central nervous system. Previous studies from this laboratory have found that one position in the third (F637) and two positions in the fourth (M823 and A825) membrane-associated (M) domains of the N-methyl-D-aspartate receptor GluN2A subunit modulate alcohol action and ion channel gating. Using site-directed mutagenesis and whole-cell patch-clamp recording, we have found an additional position in M3 of the GluN2A subunit, F636, which significantly influences ethanol sensitivity and functionally interacts with F637. Tryptophan substitution at F636 significantly decreased the ethanol IC50, decreased both peak and steady-state glutamate EC50, and altered agonist deactivation and apparent desensitization. There was a significant correlation between steadystate: peak current ratio, a measure of desensitization, and ethanol IC50 values for a series of mutants at this site, raising the possibility that changes in ethanol sensitivity may be secondary to changes in desensitization. Mutant cycle analysis revealed a significant interaction between F636 and F637 in regulating ethanol sensitivity. Our results suggest that F636 in the M3 domain of the GluN2A subunit not only influences channel gating and agonist potency, but also plays an important role in mediating the action of ethanol. These studies were supported by grants R01 AA015203-01A1 and AA015203-06A1 from the NIAAA to R.W.P
Seeing 'REDD'?: Forests, Climate Change Mitigation and the Rights of Indigenous Peoples
Examines proposals for reducing emissions from deforestation and forest degradation (REDD) and their failure to protect indigenous peoples' rights or to address forest governance problems. Calls for talks to include civil society and indigenous peoples
Single-node orbit analsyis with radiation heat transfer only
The steady-state temperature of a single node which dissipates energy by radiation only is discussed for a nontime varying thermal environment. Relationships are developed to illustrate how shields can be utilized to represent a louver system. A computer program is presented which can assess periodic temperature characteristics of a single node in a time varying thermal environment having energy dissipation by radiation only. The computer program performs thermal orbital analysis for five combinations of plate, shields, and louvers
Introduction
This issue of Law Text Culture has its genesis in a research project on Mobile Peoples Under the Eye of the Law which was originally proposed by Associate Professor Cathy Coleborne at the University of Waikato. The project was supported with a grant for a one day symposium, held in December 2010, from the University of Waikato Contrestable Research Trust Fund, for which we are grateful. As guest editors we invited contributions of postcolonial analyses that investigated mobile peoples, in Australia, New Zealand and the Pacific, both historically and in the present. We were especially interested in the ways in which regulation and surveillance in all of its forms â legal, policy, administrative and so forth â produced and constructed mobile peoples, and how categories of gender and sexuality were shaped in relation to mobile peoples in and through these regimes
DFAT indigenous peoples strategy 2015-2019: a framework for action
DFAT has developed a five-year Indigenous Peoples Strategy to align its work on issues affecting indigenous peoples across the foreign policy, aid, trade and corporate objectives for the department.
Overview
The Australian Government is committed to providing opportunities to assist indigenous peoples âboth in Australia and overseasâto overcome social and economic disadvantages.
Indigenous peoples make up only 5 per cent of the global population; however they make up 15 per cent of the worldâs poor and about one-third of the worldâs 900 million extremely poor rural people. Australiaâs first peoples are one of the oldest continuous living cultures on Earth. The contribution of Aboriginal and Torres Strait Islander peoples to modern Australian society is an enormous part of what makes our country and who we are. The Australian Government is committed to better engagement with its Indigenous peoples to ensure policies and programmes improve their lives and opportunities across the country. Globally, Australia continues to be a strong advocate for the full and effective participation of indigenous peoples around the world in international matters which affect them.
The Department of Foreign Affairs and Trade (DFAT) is committed to ensuring that indigenous peoples benefit from its work. Through a network of 95 overseas posts in 77 countries, and in partnership with government and non-government organisations, business and community groups in Australia and overseas, DFAT leads the Australian Governmentâs efforts to:
advance Australiaâs security interests internationally
open up new markets and create conditions for increased trade and investment to strengthen Australiaâs economy and to create jobs
lift living standards and reduce poverty in the Indo-Pacific region and beyond
shape the regional and international environment and strengthen global cooperation in ways that advance Australiaâs interests
project a positive and contemporary image of Australia as a destination for business, investment, tourism and study
provide high-quality passport and consular services to Australian citizens.
DFAT has developed a five-year Indigenous Peoples Strategy to align its work on issues affecting indigenous peoples across the foreign policy, aid, trade and corporate objectives for the department. The Indigenous Peoples Strategy provides a framework for DFAT to work with its partners to advance and promote the wellbeing of indigenous peoples around the world, in line with Australiaâs national interest. DFAT will use the strategy to manage for positive results and continual improvement in its work on issues affecting indigenous peoples. DFAT will assess and disseminate lessons from its work to contribute towards evidence and debate about issues affecting indigenous peoples, both in Australia and overseas.
The strategy will be guided by four pillars to achieve this vision:
DFAT will work with its partners to influence international policy to advance the interests of indigenous peoples in the international community.
DFAT will strive to deliver international programs that improve outcomes for indigenous peoples.
DFAT will encourage Indigenous Australians to apply for DFAT-funded opportunities to engage in and develop people-to-people links with the international community.
DFAT will ensure an inclusive workplace culture across the department.
DFATâs Indigenous Taskforce is responsible for monitoring the overall implementation of the Indigenous Peoples Strategy.
DFAT will conduct a mid-term review of the strategy in 2017 and a final review in 2020
Inspiration for childrenâs human rights from indigenous peoplesâ rights
Although there are many and obvious differences between children and indigenous peoples, there are also quite some similarities, especially in how international human rights law and academic research have addressed the claims of these groups. This chapter focuses on three domains in which childrenâs rights and indigenous peoplesâ rights share certain challenges, in order to explore whether and how both branches of human rights law could inspire each other: (i) the demarcation of the personal scope of rights, and the divisions and dichotomies generated by the establishment of categorical human rights; (ii) the way in which indigenous peoples and children have been constructed, especially from a Western perspective, and the consequences thereof; and (iii) participation and consent. I will argue that childrenâs rights law could draw inspiration from indigenous peoplesâ rights law in defining its rights holders, in developing the collective dimension of the right to be heard and in conceptualising the right of children to give consent. On the other hand, an area in which research and practice on both indigenous peoplesâ rights and childrenâs rights should increase efforts, concerns addressing the adverse consequences of idealised constructions
Learning as spirituality and nurture - Pacific indigenous peoples' perspectives of lifelong learning
This paper discusses characteristics of an adult education practice for peoples in the Pacific. There is no one Pacific way as the Pacific population is diverse consisting of many cultures, languages, social structures and differing colonial experiences. For many Pacific peoples learning is holistic, is driven by cultural motivation, which is often for the benefit of their extended families(the collective)rather than personal gains or self-actualisation. Learning is constantly intervened by spiritual matters, the same being true for most aspects of Pacific peoplesâ day-to-day lives. Therefore spirituality is integral to learning at all levels formal and informal
- âŠ