2,244 research outputs found

    Artificial intelligence for predictive biomarker discovery in immuno-oncology: a systematic review

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    Background: The widespread use of immune checkpoint inhibitors (ICIs) has revolutionised treatment of multiple cancer types. However, selecting patients who may benefit from ICI remains challenging. Artificial intelligence (AI) approaches allow exploitation of high-dimension oncological data in research and development of precision immuno-oncology. Materials and methods: We conducted a systematic literature review of peer-reviewed original articles studying the ICI efficacy prediction in cancer patients across five data modalities: genomics (including genomics, transcriptomics, and epigenomics), radiomics, digital pathology (pathomics), and real-world and multimodality data. Results: A total of 90 studies were included in this systematic review, with 80% published in 2021-2022. Among them, 37 studies included genomic, 20 radiomic, 8 pathomic, 20 real-world, and 5 multimodal data. Standard machine learning (ML) methods were used in 72% of studies, deep learning (DL) methods in 22%, and both in 6%. The most frequently studied cancer type was non-small-cell lung cancer (36%), followed by melanoma (16%), while 25% included pan-cancer studies. No prospective study design incorporated AI-based methodologies from the outset; rather, all implemented AI as a post hoc analysis. Novel biomarkers for ICI in radiomics and pathomics were identified using AI approaches, and molecular biomarkers have expanded past genomics into transcriptomics and epigenomics. Finally, complex algorithms and new types of AI-based markers, such as meta-biomarkers, are emerging by integrating multimodal/multi-omics data. Conclusion: AI-based methods have expanded the horizon for biomarker discovery, demonstrating the power of integrating multimodal data from existing datasets to discover new meta-biomarkers. While most of the included studies showed promise for AI-based prediction of benefit from immunotherapy, none provided high-level evidence for immediate practice change. A priori planned prospective trial designs are needed to cover all lifecycle steps of these software biomarkers, from development and validation to integration into clinical practice

    Machine learning for real-time prediction of complications induced by flexible uretero-renoscopy with laser lithotripsy

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    It is not always easy to predict the outcome of a surgery. Peculiarly, when talking about the risks associated to a given intervention or the possible complications that it may bring about. Thus, predicting those potential complications that may arise during or after a surgery will help minimize risks and prevent failures to the greatest extent possible. Therefore, the objectif of this article is to propose an intelligent system based on machine learning, allowing predicting the complications related to a flexible uretero-renoscopy with laser lithotripsy for the treatment of kidney stones. The proposed method achieved accuracy with 100% for training and, 94.33% for testing in hard voting, 100% for testing and 95.38% for training in soft voting, with only ten optimal features. Additionally, we were able to evaluted the machine learning model by examining the most significant features using the shpley additive explanations (SHAP) feature importance plot, dependency plot, summary plot, and partial dependency plots

    Multidisciplinary perspectives on Artificial Intelligence and the law

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    This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio

    Predicting rapid intensification of tropical cyclones in the western North Pacific: a machine learning and net energy gain rate approach

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    In this study, a machine learning (ML)-based Tropical Cyclones (TCs) Rapid Intensification (RI) prediction model has been developed by using the Net Energy Gain Rate Index (NGR). This index realistically captures the energy exchanges between the ocean and the atmosphere during the intensification of TCs. It does so by incorporating the thermal conditions of the upper ocean and using an accurate parameterization for sea surface roughness. To evaluate the effectiveness of NGR in enhancing prediction accuracy, five distinct ML algorithms were utilized: Decision Tree, Logistic Regression, Support Vector Machine, K-Nearest Neighbors, and Feed-forward Neural Network. Two sets of experiments were performed for each algorithm. The first set used only traditional predictors, while the second set incorporated NGR. The outcomes revealed that models trained with the inclusion of NGR exhibited superior performance compared to those that only used traditional predictors. Additionally, an ensemble model was developed by utilizing a hard-voting method, combining the predictions of all five individual algorithms. This ensemble approach showed a noteworthy improvement of approximately 10% in the skill score of RI prediction when NGR was included. The findings of this study emphasize the potential of NGR in refining TC intensity prediction and underline the effectiveness of ensemble ML models in RI event detection

    LIPIcs, Volume 251, ITCS 2023, Complete Volume

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    LIPIcs, Volume 251, ITCS 2023, Complete Volum

    Machine learning applications in search algorithms for gravitational waves from compact binary mergers

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    Gravitational waves from compact binary mergers are now routinely observed by Earth-bound detectors. These observations enable exciting new science, as they have opened a new window to the Universe. However, extracting gravitational-wave signals from the noisy detector data is a challenging problem. The most sensitive search algorithms for compact binary mergers use matched filtering, an algorithm that compares the data with a set of expected template signals. As detectors are upgraded and more sophisticated signal models become available, the number of required templates will increase, which can make some sources computationally prohibitive to search for. The computational cost is of particular concern when low-latency alerts should be issued to maximize the time for electromagnetic follow-up observations. One potential solution to reduce computational requirements that has started to be explored in the last decade is machine learning. However, different proposed deep learning searches target varying parameter spaces and use metrics that are not always comparable to existing literature. Consequently, a clear picture of the capabilities of machine learning searches has been sorely missing. In this thesis, we closely examine the sensitivity of various deep learning gravitational-wave search algorithms and introduce new methods to detect signals from binary black hole and binary neutron star mergers at previously untested statistical confidence levels. By using the sensitive distance as our core metric, we allow for a direct comparison of our algorithms to state-of-the-art search pipelines. As part of this thesis, we organized a global mock data challenge to create a benchmark for machine learning search algorithms targeting compact binaries. This way, the tools developed in this thesis are made available to the greater community by publishing them as open source software. Our studies show that, depending on the parameter space, deep learning gravitational-wave search algorithms are already competitive with current production search pipelines. We also find that strategies developed for traditional searches can be effectively adapted to their machine learning counterparts. In regions where matched filtering becomes computationally expensive, available deep learning algorithms are also limited in their capability. We find reduced sensitivity to long duration signals compared to the excellent results for short-duration binary black hole signals

    Representing Input Transformations by Low-Dimensional Parameter Subspaces

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    Deep models lack robustness to simple input transformations such as rotation, scaling, and translation, unless they feature a particular invariant architecture or undergo specific training, e.g., learning the desired robustness from data augmentations. Alternatively, input transformations can be treated as a domain shift problem, and solved by post-deployment model adaptation. Although a large number of methods deal with transformed inputs, the fundamental relation between input transformations and optimal model weights is unknown. In this paper, we put forward the configuration subspace hypothesis that model weights optimal for parameterized continuous transformations can reside in low-dimensional linear subspaces. We introduce subspace-configurable networks to learn these subspaces and observe their structure and surprisingly low dimensionality on all tested transformations, datasets and architectures from computer vision and audio signal processing domains. Our findings enable efficient model reconfiguration, especially when limited storage and computing resources are at stake

    A reduced-rank approach to predicting multiple binary responses through machine learning

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    This paper investigates the problem of simultaneously predicting multiple binary responses by utilizing a shared set of covariates. Our approach incorporates machine learning techniques for binary classification, without making assumptions about the underlying observations. Instead, our focus lies on a group of predictors, aiming to identify the one that minimizes prediction error. Unlike previous studies that primarily address estimation error, we directly analyze the prediction error of our method using PAC-Bayesian bounds techniques. In this paper, we introduce a pseudo-Bayesian approach capable of handling incomplete response data. Our strategy is efficiently implemented using the Langevin Monte Carlo method. Through simulation studies and a practical application using real data, we demonstrate the effectiveness of our proposed method, producing comparable or sometimes superior results compared to the current state-of-the-art method

    Spatio-Temporal Wildfire Prediction using Multi-Modal Data

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    Due to severe societal and environmental impacts, wildfire prediction using multi-modal sensing data has become a highly sought-after data-analytical tool by various stakeholders (such as state governments and power utility companies) to achieve a more informed understanding of wildfire activities and plan preventive measures. A desirable algorithm should precisely predict fire risk and magnitude for a location in real time. In this paper, we develop a flexible spatio-temporal wildfire prediction framework using multi-modal time series data. We first predict the wildfire risk (the chance of a wildfire event) in real-time, considering the historical events using discrete mutually exciting point process models. Then we further develop a wildfire magnitude prediction set method based on the flexible distribution-free time-series conformal prediction (CP) approach. Theoretically, we prove a risk model parameter recovery guarantee, as well as coverage and set size guarantees for the CP sets. Through extensive real-data experiments with wildfire data in California, we demonstrate the effectiveness of our methods, as well as their flexibility and scalability in large regions

    A Comprehensive Survey of Artificial Intelligence Techniques for Talent Analytics

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    In today's competitive and fast-evolving business environment, it is a critical time for organizations to rethink how to make talent-related decisions in a quantitative manner. Indeed, the recent development of Big Data and Artificial Intelligence (AI) techniques have revolutionized human resource management. The availability of large-scale talent and management-related data provides unparalleled opportunities for business leaders to comprehend organizational behaviors and gain tangible knowledge from a data science perspective, which in turn delivers intelligence for real-time decision-making and effective talent management at work for their organizations. In the last decade, talent analytics has emerged as a promising field in applied data science for human resource management, garnering significant attention from AI communities and inspiring numerous research efforts. To this end, we present an up-to-date and comprehensive survey on AI technologies used for talent analytics in the field of human resource management. Specifically, we first provide the background knowledge of talent analytics and categorize various pertinent data. Subsequently, we offer a comprehensive taxonomy of relevant research efforts, categorized based on three distinct application-driven scenarios: talent management, organization management, and labor market analysis. In conclusion, we summarize the open challenges and potential prospects for future research directions in the domain of AI-driven talent analytics.Comment: 30 pages, 15 figure
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