583 research outputs found

    Design-for-Test of Mixed-Signal Integrated Circuits

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    Regression modeling for digital test of ΣΔ modulators

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    The cost of Analogue and Mixed-Signal circuit testing is an important bottleneck in the industry, due to timeconsuming verification of specifications that require state-ofthe- art Automatic Test Equipment. In this paper, we apply the concept of Alternate Test to achieve digital testing of converters. By training an ensemble of regression models that maps simple digital defect-oriented signatures onto Signal to Noise and Distortion Ratio (SNDR), an average error of 1:7% is achieved. Beyond the inference of functional metrics, we show that the approach can provide interesting diagnosis information.Ministerio de Educación y Ciencia TEC2007-68072/MICJunta de Andalucía TIC 5386, CT 30

    Some advances in extensive bridge monitoring using low cost dynamic characterization

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    Dynamic measurements will become a standard for bridge monitoring in the near future. This fact will produce an important cost reduction for maintenance. US Administration has a long term intensive research program in order to diminish the estimated current maintenance cost of US$7 billion per year over 20 years. An optimal intervention maintenance program demands a historical dynamical record, as well as an updated mathematical model of the structure to be monitored. In case that a model of the structure is not actually available it is possible to produce it, however this possibility does not exist for missing measurement records from the past. Current acquisition systems to monitor structures can be made more efficient by introducing the following improvements, under development in the Spanish research Project “Low cost bridge health monitoring by ambient vibration tests using wireless sensors”: (a) a complete wireless system to acquire sensor data, (b) a wireless system that permits the localization and the hardware identification of the whole sensor system. The applied localization system has been object of a recent patent, and (c) automatization of the modal identification process, aimed to diminish human intervention. This system is assembled with cheap components and allows the simultaneous use of a large number of sensors at a low placement cost. The engineer’s intervention is limited to the selection of sensor positions, probably based on a preliminary FE analysis. In case of multiple setups, also the position of a number of fixed reference sensors has to be decided. The wireless localization system will obtain the exact coordinates of all these sensors positions. When the selection of optimal positions is difficult, for example because of the lack of a proper FE model, this can be compensated by using a higher number of measuring (also reference) points. The described low cost acquisition system allows the responsible bridge administration to obtain historical dynamic identification records at reasonable costs that will be used in future maintenance programs. Therefore, due to the importance of the baseline monitoring record of a new bridge, a monitoring test just after its construction should be highly recommended, if not compulsory

    Advanced techniques for diagnostics and control applied to particle accelerators

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    201 p.Esta tesis versa en torno a tecnologías y técnicas novedosas orientadas al diagnóstico y control para aceleradores de partículas. Se centra principalmente en el desarrollo de dos aplicaciones para dicho propósito; un monitor de posición de haz (beam position monitor o BPM en inglés) por un lado, y un control de RF denominado sistema de RF de bajo nivel (low-level RF o LLRF en inglés) por el otro. Además, se han desarrollado completos bancos de pruebas, permitiendo de esta manera el testeo de las mencionadas soluciones en el laboratorio. El estudio de técnicas de muestreo y procesamiento digital para su posterior implementación también juega un papel importante en este trabajo.De esta manera, las principales contribuciones de esta tesis son el desarrollo de un BPM y un sistema de control LLRF altamente flexibles y reconfigurables, estando ambos basados en hardware digital. Las soluciones presentadas han sido diseñadas con el objetivo de crear herramientas especialmente adecuadas para labores de investigación en laboratorio. Las aplicaciones obtenidas cumplen este objetivo, mostrando características especialmente valiosas como una rápida etapa de prototipado y alta modularidad.Otra línea de la presente tesis está dirigida al estudio de técnicas avanzadas de muestreo y procesamiento digital de señal, las cuales son posteriormente implementadas en las citadas aplicaciones. Finalmente, la última parte de este trabajo trata sobre la integración de la información producida por estas herramientas de diagnóstico y control en EPICS, un sistema de control ampliamente utilizado en el campo de los aceleradores de partículas

    Optical sampling and metrology using a soliton-effect compression pulse source

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    A low jitter optical pulse source for applications including optical sampling and optical metrology was modelled and then experimentally implemented using photonic components. Dispersion and non-linear fibre effects were utilised to compress a periodic optical waveform to generate pulses of the order of 10 picoseconds duration, via soliton-effect compression. Attractive features of this pulse source include electronically tuneable repetition rates greater than 1.5 GHz, ultra-short pulse duration (10-15 ps), and low timing jitter as measured by both harmonic analysis and single-sideband (SSB) phase noise measurements. The experimental implementation of the modelled compression scheme is discussed, including the successful removal of stimulated Brillouin scattering (SBS) through linewidth broadening by injection dithering or phase modulation. Timing jitter analysis identifies many unwanted artefacts generated by the SBS suppression methods, hence an experimental arrangement is devised (and was subsequently patented) which ensures that there are no phase modulation spikes present on the SSB phase noise spectrum over the offset range of interest for optical sampling applications, 10Hz-Nyquist. It is believed that this is the first detailed timing jitter study of a soliton-effect compression scheme. The soliton-effect compression pulses are then used to perform what is believed to be the first demonstration of optical sampling using this type of pulse source. The pulse source was also optimised for use in a novel optical metrology (range finding) system, which is being developed and patented under European Space Agency funding as an enabling technology for formation flying satellite missions. This new approach to optical metrology, known as Scanning Interferometric Pulse Overlap Detection (SIPOD), is based on scanning the optical pulse repetition rate to find the specific frequencies which allow the return pulses from the outlying satellite, i.e. the measurement arm, to overlap exactly with a reference pulse set on the hub satellite. By superimposing a low frequency phase modulation onto the optical pulse train, it is possible to detect the pulse overlap condition using conventional heterodyne detection. By rapidly scanning the pulse repetition rate to find two frequencies which provide the overlapping pulse condition, high precision optical pulses can be used to provide high resolution unambiguous range information, using only relatively simple electronic detection circuitry. SIPOD’s maximum longitudinal range measurement is limited only by the coherence length of the laser, which can be many tens of kilometres. Range measurements have been made to better than 10 microns resolution over extended duration trial periods, at measurement update rates of up to 470 Hz. This system is currently scheduled to fly on ESA’s PROBA-3 mission in 2012 to measure the intersatellite spacing for a two satellite coronagraph instrument. In summary, this thesis is believed to present three novel areas of research: the first detailed jitter characterisation of a soliton-effect compression source, the first optical sampling using such a compression source, and a novel optical metrology range finding system, known as SIPOD, which utilises the tuneable repetition rate and highly stable nature of the compression source pulses

    Novel techniques for the design and practical realization of switched-capacitor circuits in deep-submicron CMOS technologies

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    Dissertação apresentada para obtenção do Grau de Doutor em Engenharia Electrotécnica e de Computadores pela Universidade Nova de Lisboa, Faculdade de Ciências e TecnologiaSwitches presenting high linearity are more and more required in switched-capacitor circuits,namely in 12 to 16 bits resolution analog-to-digital converters. The CMOS technology evolves continuously towards lower supply voltages and, simultaneously, new design techniques are necessary to fulfill the realization of switches exhibiting a high dynamic range and a distortion compatible with referred resolutions. Moreover, with the continuously downing of the sizes, the physic constraints of the technology must be considered to avoid the excessive stress of the devices when relatively high voltages are applied to the gates. New switch-linearization techniques, with high reliability, must be necessarily developed and demonstrated in CMOS integrated circuits. Also, the research of new structures of circuits with switched-capacitor is permanent. Simplified and efficient structures are mandatory, adequate to the new demands emerging from the proliferation of portable equipments, necessarily with low energy consumption while assuring high performance and multiple functions. The work reported in this Thesis comprises these two areas. The behavior of the switches under these new constraints is analyzed, being a new and original solution proposed, in order to maintain the performance. Also, proposals for the application of simpler clock and control schemes are presented, and for the use of open-loop structures and amplifiers with localfeedback. The results, obtained in laboratory or by simulation, assess the feasibility of the presented proposals

    Magnetic attitude control of LAICE satellite with aerodynamic stabilization

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    The Lower Atmosphere Ionosphere Coupling Experiment (LAICE) is a NanoSatellite which will be performing in-situ measurements of neutral and ion densities in the mesosphere, lower thermosphere, and ionosphere and correlating them to measurements of gravity waves in the lower atmosphere. The satellite is based on a new 6U CubeSat form factor based on the IlliniSat 2 bus developed at the University of Illinois at Urbana-Champaign. The satellite’s payloads need to be oriented such that three instruments are oriented along the velocity direction of the satellite, while a fourth instrument is pointed towards nadir. The attitude determination and control system must achieve the attitude pointing requirements (5° from nominal attitude) with minimum of cost and low power. The satellite will therefore make use of magnetic torque coils augmented with aerodynamic stabilization to accomplish the mission attitude control requirements. The proposed control method relies on passive aerodynamic stabilization of the spacecraft to maintain pointing in the satellite normal frame. The aerodynamic stabilization reduces the dimensionality of the magnetic attitude control to a one-dimensional problem. The major contributions of this work include the development of an object-oriented attitude control library with which to program flight code as well as simulate satellite dynamics to validate the flight code; the development and tuning of an Extended Kalman Filter for attitude determination using low-cost magnetometers and MEMS gyros; the development and tuning of a hybrid attitude control algorithm for magnetic torque coils which can reliably detumble and reorient the satellite; the development of an efficient graphical drag model for computing aerodynamic torques; and the novel use of a tri-axial Helmholtz cage for performing a Hardware-in-Loop optimization of the coupled attitude determination and control system

    Electronic Devices for the Combination of Electrically Controlled Drug Release, Electrostimulation, and Optogenetic Stimulation for Nerve Tissue Regeneration

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    [ES] La capacidad de las células madre para proliferar formando distintas células especializadas les otorga la potencialidad de servir de base para terapias efectivas para patologías cuyo tratamiento era inimaginable hasta hace apenas dos décadas. Sin embargo, esta capacidad se encuentra mediada por estímulos fisiológicos, químicos, y eléctricos, específicos y complejos, que dificultan su traslación a la rutina clínica. Por ello, las células madre representan un campo de estudio en el que se invierten amplios esfuerzos por parte de la comunidad científica. En el ámbito de la regeneración nerviosa, para modular su desarrollo y diferenciación el tratamiento farmacológico, la electroestimulación, y la estimulación optogenética son técnicas que están consiguiendo prometedores resultados. Es por ello por lo que en la presente tesis se ha desarrollado un conjunto de sistemas electrónicos para permitir la aplicación combinada de estas técnicas in vitro, con perspectiva a su aplicación in vivo. Hemos diseñado una novedosa tecnología para la liberación eléctricamente controlada de fármacos. Esta tecnología está basada en nanopartículas de sílice mesoporosa y puertas moleculares de bipiridina-heparina. Las puertas moleculares son electroquímicamente reactivas, y encierran los fármacos en el interior de las nanopartículas, liberándolos ante un estímulo eléctrico. Hemos caracterizado esta tecnología, y la hemos validado mediante la liberación controlada de rodamina en cultivos celulares de HeLa. Para la combinación de liberación controlada de fármacos y electroestimulación hemos desarrollado dispositivos que permiten aplicar los estímulos eléctricos de forma configurable desde una interfaz gráfica de usuario. Además, hemos diseñado un módulo de expansión que permite multiplexar las señales eléctricas a diferentes cultivos celulares. Además, hemos diseñado un dispositivo de estimulación optogenética. Este tipo de estimulación consiste en la modificación genética de las células para que sean sensibles a la radiación lumínica de determinada longitud de onda. En el ámbito de la regeneración de tejido mediante células precursoras neurales, es de interés poder inducir ondas de calcio, favoreciendo su diferenciación en neuronas y la formación de circuitos sinápticos. El dispositivo diseñado permite obtener imágenes en tiempo real mediante microscopía confocal de las respuestas transitorias de las células al ser irradiadas. El dispositivo se ha validado irradiando neuronas modificadas con luz pulsada de 100 ms. También hemos diseñado un dispositivo electrónico complementario de medida de irradiancia con el doble fin de permitir la calibración del equipo de irradiancia y medir la irradiancia en tiempo real durante los experimentos in vitro. Los resultados del uso de los bioactuadores en procesos complejos y dinámicos, como la regeneración de tejido nervioso, son limitados en lazo abierto. Uno de los principales aspectos analizados es el desarrollo de biosensores que permitiesen la cuantización de ciertas biomoléculas para ajustar la estimulación suministrada en tiempo real. Por ejemplo, la segregación de serotonina es una respuesta identificada en la elongación de células precursoras neurales, pero hay otras biomoléculas de interés para la implementación de un control en lazo cerrado. Entre las tecnologías en el estado del arte, los biosensores basados en transistores de efecto de campo (FET) funcionalizados con aptámeros son realmente prometedores para esta aplicación. Sin embargo, esta tecnología no permitía la medición simultánea de más de una biomolécula objetivo en un volumen reducido debido a las interferencias entre los distintos FETs, cuyos terminales se encuentran inmersos en la solución. Por ello, hemos desarrollado instrumentación electrónica capaz de medir simultáneamente varios de estos biosensores, y la hemos validado mediante la medición simultánea de pH y la detección preliminar de serotonina y glutamato.[CA] La capacitat de les cèl·lules mare per a proliferar formant diferents cèl·lules especialitzades els atorga la potencialitat de servir de base per a teràpies efectives per a patologies el tractament de les quals era inimaginable fins fa a penes dues dècades. No obstant això, aquesta capacitat es troba mediada per estímuls fisiològics, químics, i elèctrics, específics i complexos, que dificulten la seua translació a la rutina clínica. Per això, les cèl·lules mare representen un camp d'estudi en el qual s'inverteixen amplis esforços per part de la comunitat científica. En l'àmbit de la regeneració nerviosa, per a modular el seu desenvolupament i diferenciació el tractament farmacològic, l'electroestimulació, i l'estimulació optogenética són tècniques que estan aconseguint prometedors resultats. És per això que en la present tesi s'ha desenvolupat un conjunt de sistemes electrònics per a permetre l'aplicació combinada d'aquestes tècniques in vitro, amb perspectiva a la seua aplicació in vivo. Hem dissenyat una nova tecnologia per a l'alliberament elèctricament controlat de fàrmacs. Aquesta tecnologia està basada en nanopartícules de sílice mesoporosa i portes moleculars de bipiridina-heparina. Les portes moleculars són electroquímicament reactives, i tanquen els fàrmacs a l'interior de les nanopartícules, alliberant-los davant un estímul elèctric. Hem caracteritzat aquesta tecnologia, i l'hem validada mitjançant l'alliberament controlat de rodamina en cultius cel·lulars de HeLa. Per a la combinació d'alliberament controlat de fàrmacs i electroestimulació hem desenvolupat dispositius que permeten aplicar els estímuls elèctrics de manera configurable des d'una interfície gràfica d'usuari. A més, hem dissenyat un mòdul d'expansió que permet multiplexar els senyals elèctrics a diferents cultius cel·lulars. A més, hem dissenyat un dispositiu d'estimulació optogenètica. Aquest tipus d'estimulació consisteix en la modificació genètica de les cèl·lules perquè siguen sensibles a la radiació lumínica de determinada longitud d'ona. En l'àmbit de la regeneració de teixit mitjançant cèl·lules precursores neurals, és d'interés poder induir ones de calci, afavorint la seua diferenciació en neurones i la formació de circuits sinàptics. El dispositiu dissenyat permet obtindré imatges en temps real mitjançant microscòpia confocal de les respostes transitòries de les cèl·lules en ser irradiades. El dispositiu s'ha validat irradiant neurones modificades amb llum polsada de 100 ms. També hem dissenyat un dispositiu electrònic complementari de mesura d'irradiància amb el doble fi de permetre el calibratge de l'equip d'irradiància i mesurar la irradiància en temps real durant els experiments in vitro. Els resultats de l'ús dels bioactuadors en processos complexos i dinàmics, com la regeneració de teixit nerviós, són limitats en llaç obert. Un dels principals aspectes analitzats és el desenvolupament de biosensors que permeteren la quantització de certes biomolècules per a ajustar l'estimulació subministrada en temps real. Per exemple, la segregació de serotonina és una resposta identificada amb l'elongació de les cèl·lules precursores neurals, però hi ha altres biomolècules d'interés per a la implementació d'un control en llaç tancat. Entre les tecnologies en l'estat de l'art, els biosensors basats en transistors d'efecte de camp (FET) funcionalitzats amb aptàmers són realment prometedors per a aquesta aplicació. No obstant això, aquesta tecnologia no permetia el mesurament simultani de més d'una biomolècula objectiu en un volum reduït a causa de les interferències entre els diferents FETs, els terminals dels quals es troben immersos en la solució. Per això, hem desenvolupat instrumentació electrònica capaç de mesurar simultàniament diversos d'aquests biosensors i els hem validat amb mesurament simultani del pH i la detecció preliminar de serotonina i glutamat.[EN] The stem cells' ability to proliferate to form different specialized cells gives them the potential to serve as the basis for effective therapies for pathologies whose treatment was unimaginable until just two decades ago. However, this capacity is mediated by specific and complex physiological, chemical, and electrical stimuli that complicate their translation to clinical routine. For this reason, stem cells represent a field of study in which the scientific community is investing a great deal of effort. In the field of nerve regeneration, to modulate their development and differentiation, pharmacological treatment, electrostimulation, and optogenetic stimulation are techniques that are achieving promising results. For this reason, we have developed a set of electronic systems to allow the combined application of these techniques in vitro, with a view to their application in vivo. We have designed a novel technology for the electrically controlled release of drugs. This technology is based on mesoporous silica nanoparticles and bipyridine-heparin molecular gates. The molecular gates are electrochemically reactive and entrap the drugs inside the nanoparticles, releasing them upon electrical stimulus. We have characterized this technology and validated it by controlled release of rhodamine in HeLa cell cultures. For combining electrostimulation and controlled drug release we have developed devices that allow applying the different electrical stimuli in a configurable way from a graphical user interface. In addition, we have designed an expansion module that allows multiplexing electrical signals to different cell cultures. In addition, we have designed an optogenetic stimulation device. This type of stimulation consists of genetically modifying cells to make them sensitive to light radiation of a specific wavelength. In tissue regeneration using neural precursor cells, it is interesting to be able to induce calcium waves, favoring the cell differentiation into neurons and the formation of synaptic circuits. The designed device enable the obtention of real-time images through confocal microscopy of the transient responses of cells upon irradiation. The device has been validated by irradiating modified neurons with 100 ms pulsed light stimulation. We have also designed a complementary electronic irradiance measurement device to allow calibration of the irradiator equipment and measuring irradiance in real time during in vitro experiments. The results of using bioactuators in complex and dynamic processes, such as nerve tissue regeneration, are limited in an open loop. One of the main aspects analyzed is the development of biosensors that would allow quantifying of specific biomolecules to adjust the stimulation provided in real time. For instance, serotonin secretion is an identified response of neural precursor cells elongation, among other biomolecules of interest for the implementation of a closed-loop control. Among the state-of-the-art technologies, biosensors based on field effect transistors (FETs) functionalized with aptamers are promising for this application. However, this technology did not allow the simultaneous measurement of more than one target biomolecule in a small volume due to interferences between the different FETs, whose terminals are immersed in the solution. This is why we have developed electronic instrumentation capable of simultaneously measuring several of these biosensors, and we have validated it with the simultaneous pH measurement and the preliminary detection of serotonin and glutamate.Monreal Trigo, J. (2023). Electronic Devices for the Combination of Electrically Controlled Drug Release, Electrostimulation, and Optogenetic Stimulation for Nerve Tissue Regeneration [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/19384
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