Coding Strategies for Cochlear Implants Under Adverse Environments

Cochlear implants are electronic prosthetic devices that restores partial hearing in patients with severe to profound hearing loss. Although most coding strategies have significantly improved the perception of speech in quite listening conditions, there remains limitations on speech perception under adverse environments such as in background noise, reverberation and band-limited channels, and we propose strategies that improve the intelligibility of speech transmitted over the telephone networks, reverberated speech and speech in the presence of background noise. For telephone processed speech, we propose to examine the effects of adding low-frequency and high- frequency information to the band-limited telephone speech. Four listening conditions were designed to simulate the receiving frequency characteristics of telephone handsets. Results indicated improvement in cochlear implant and bimodal listening when telephone speech was augmented with high frequency information and therefore this study provides support for design of algorithms to extend the bandwidth towards higher frequencies. The results also indicated added benefit from hearing aids for bimodal listeners in all four types of listening conditions. Speech understanding in acoustically reverberant environments is always a difficult task for hearing impaired listeners. Reverberated sounds consists of direct sound, early reflections and late reflections. Late reflections are known to be detrimental to speech intelligibility. In this study, we propose a reverberation suppression strategy based on spectral subtraction to suppress the reverberant energies from late reflections. Results from listening tests for two reverberant conditions (RT60 = 0.3s and 1.0s) indicated significant improvement when stimuli was processed with SS strategy. The proposed strategy operates with little to no prior information on the signal and the room characteristics and therefore, can potentially be implemented in real-time CI speech processors. For speech in background noise, we propose a mechanism underlying the contribution of harmonics to the benefit of electroacoustic stimulations in cochlear implants. The proposed strategy is based on harmonic modeling and uses synthesis driven approach to synthesize the harmonics in voiced segments of speech. Based on objective measures, results indicated improvement in speech quality. This study warrants further work into development of algorithms to regenerate harmonics of voiced segments in the presence of noise

Real-time dynamic articulations in the 2-D waveguide mesh vocal tract model

Time domain articulatory vocal tract modeling in one-dimensional (1-D) is well established. Previous studies into two-dimensional (2-D) simulation of wave propagation in the vocal tract have shown it to present accurate static vowel synthesis. However, little has been done to demonstrate how such a model might accommodate the dynamic tract shape changes necessary in modeling speech. Two methods of applying the area function to the 2-D digital waveguide mesh vocal tract model are presented here. First, a method based on mapping the cross-sectional area onto the number of waveguides across the mesh, termed a widthwise mapping approach is detailed. Discontinuity problems associated with the dynamic manipulation of the model are highlighted. Second, a new method is examined that uses a static-shaped rectangular mesh with the area function translated into an impedance map which is then applied to each waveguide. Two approaches for constructing such a map are demonstrated; one using a linear impedance increase to model a constriction to the tract and another using a raised cosine function. Recommendations are made towards the use of the cosine method as it allows for a wider central propagational channel. It is also shown that this impedance mapping approach allows for stable dynamic shape changes and also permits a reduction in sampling frequency leading to real-time interaction with the model

Parametric spatial audio processing utilising compact microphone arrays

This dissertation focuses on the development of novel parametric spatial audio techniques using compact microphone arrays. Compact arrays are of special interest since they can be adapted to fit in portable devices, opening the possibility of exploiting the potential of immersive spatial audio algorithms in our daily lives. The techniques developed in this thesis consider the use of signal processing algorithms adapted for human listeners, thus exploiting the capabilities and limitations of human spatial hearing. The findings of this research are in the following three areas of spatial audio processing: directional filtering, spatial audio reproduction, and direction of arrival estimation.  In directional filtering, two novel algorithms have been developed based on the cross-pattern coherence (CroPaC). The method essentially exploits the directional response of two different types of beamformers by using their cross-spectrum to estimate a soft masker. The soft masker provides a probability-like parameter that indicates whether there is sound present in specific directions. It is then used as a post-filter to provide further suppression of directionally distributed noise at the output of a beamformer. The performance of these algorithms represent a significant improvement over previous state-of-the-art methods.  In parametric spatial audio reproduction, an algorithm is developed for multi-channel loudspeaker and headphone rendering. Current limitations in spatial audio reproduction are related to high inter-channel coherence between the channels, which is common in signal-independent systems, or time-frequency artefacts in parametric systems. The developed algorithm focuses on solving these limitations by utilising two sets of beamformers. The first set of beamformers, namely analysis beamformers, is used to estimate a set of perceptually-relevant sound-field parameters, such as the separate channel energies, inter-channel time differences and inter-channel coherences of the target-output-setup signals. The directionality of the analysis beamformers is defined so that it follows that of typical loudspeaker panning functions and, for headphone reproduction, that of the head-related transfer functions (HRTFs). The directionality of the second set of high audio quality beamformers is then enhanced with the parametric information derived from the analysis beamformers. Listening tests confirm the perceptual benefit of such type of processing. In direction of arrival (DOA) estimation, histogram analysis of beamforming and active intensity based DOA estimators has been proposed. Numerical simulations and experiments with prototype and commercial microphone arrays show that the accuracy of DOA estimation is improved

Noise-Robust Voice Conversion

A persistent challenge in speech processing is the presence of noise that reduces the quality of speech signals. Whether natural speech is used as input or speech is the desirable output to be synthesized, noise degrades the performance of these systems and causes output speech to be unnatural. Speech enhancement deals with such a problem, typically seeking to improve the input speech or post-processes the (re)synthesized speech. An intriguing complement to post-processing speech signals is voice conversion, in which speech by one person (source speaker) is made to sound as if spoken by a different person (target speaker). Traditionally, the majority of speech enhancement and voice conversion methods rely on parametric modeling of speech. A promising complement to parametric models is an inventory-based approach, which is the focus of this work. In inventory-based speech systems, one records an inventory of clean speech signals as a reference. Noisy speech (in the case of enhancement) or target speech (in the case of conversion) can then be replaced by the best-matching clean speech in the inventory, which is found via a correlation search method. Such an approach has the potential to alleviate intelligibility and unnaturalness issues often encountered by parametric modeling speech processing systems. This work investigates and compares inventory-based speech enhancement methods with conventional ones. In addition, the inventory search method is applied to estimate source speaker characteristics for voice conversion in noisy environments. Two noisy-environment voice conversion systems were constructed for a comparative study: a direct voice conversion system and an inventory-based voice conversion system, both with limited noise filtering at the front end. Results from this work suggest that the inventory method offers encouraging improvements over the direct conversion method

Control of feedback for assistive listening devices

Acoustic feedback refers to the undesired acoustic coupling between the loudspeaker and microphone in hearing aids. This feedback channel poses limitations to the normal operation of hearing aids under varying acoustic scenarios. This work makes contributions to improve the performance of adaptive feedback cancellation techniques and speech quality in hearing aids. For this purpose a two microphone approach is proposed and analysed; and probe signal injection methods are also investigated and improved upon

Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system (CNS) and other body systems. MEMRI has since been employed in the investigation of physiology in many animal models and in humans. Here, we review historical perspectives that follow the evolution of applied MRI research into MEMRI with particular focus on its potential toxicity. Furthermore, we discuss the more current in vivo investigative uses of MEMRI in CNS investigations and the brief but decorated clinical usage of chelated manganese compound mangafodipir in humans

Speech Enhancement Exploiting the Source-Filter Model

Imagining everyday life without mobile telephony is nowadays hardly possible. Calls are being made in every thinkable situation and environment. Hence, the microphone will not only pick up the user’s speech but also sound from the surroundings which is likely to impede the understanding of the conversational partner. Modern speech enhancement systems are able to mitigate such effects and most users are not even aware of their existence. In this thesis the development of a modern single-channel speech enhancement approach is presented, which uses the divide and conquer principle to combat environmental noise in microphone signals. Though initially motivated by mobile telephony applications, this approach can be applied whenever speech is to be retrieved from a corrupted signal. The approach uses the so-called source-filter model to divide the problem into two subproblems which are then subsequently conquered by enhancing the source (the excitation signal) and the filter (the spectral envelope) separately. Both enhanced signals are then used to denoise the corrupted signal. The estimation of spectral envelopes has quite some history and some approaches already exist for speech enhancement. However, they typically neglect the excitation signal which leads to the inability of enhancing the fine structure properly. Both individual enhancement approaches exploit benefits of the cepstral domain which offers, e.g., advantageous mathematical properties and straightforward synthesis of excitation-like signals. We investigate traditional model-based schemes like Gaussian mixture models (GMMs), classical signal processing-based, as well as modern deep neural network (DNN)-based approaches in this thesis. The enhanced signals are not used directly to enhance the corrupted signal (e.g., to synthesize a clean speech signal) but as so-called a priori signal-to-noise ratio (SNR) estimate in a traditional statistical speech enhancement system. Such a traditional system consists of a noise power estimator, an a priori SNR estimator, and a spectral weighting rule that is usually driven by the results of the aforementioned estimators and subsequently employed to retrieve the clean speech estimate from the noisy observation. As a result the new approach obtains significantly higher noise attenuation compared to current state-of-the-art systems while maintaining a quite comparable speech component quality and speech intelligibility. In consequence, the overall quality of the enhanced speech signal turns out to be superior as compared to state-of-the-art speech ehnahcement approaches.Mobiltelefonie ist aus dem heutigen Leben nicht mehr wegzudenken. Telefonate werden in beliebigen Situationen an beliebigen Orten geführt und dabei nimmt das Mikrofon nicht nur die Sprache des Nutzers auf, sondern auch die Umgebungsgeräusche, welche das Verständnis des Gesprächspartners stark beeinflussen können. Moderne Systeme können durch Sprachverbesserungsalgorithmen solchen Effekten entgegenwirken, dabei ist vielen Nutzern nicht einmal bewusst, dass diese Algorithmen existieren. In dieser Arbeit wird die Entwicklung eines einkanaligen Sprachverbesserungssystems vorgestellt. Der Ansatz setzt auf das Teile-und-herrsche-Verfahren, um störende Umgebungsgeräusche aus Mikrofonsignalen herauszufiltern. Dieses Verfahren kann für sämtliche Fälle angewendet werden, in denen Sprache aus verrauschten Signalen extrahiert werden soll. Der Ansatz nutzt das Quelle-Filter-Modell, um das ursprüngliche Problem in zwei Unterprobleme aufzuteilen, die anschließend gelöst werden, indem die Quelle (das Anregungssignal) und das Filter (die spektrale Einhüllende) separat verbessert werden. Die verbesserten Signale werden gemeinsam genutzt, um das gestörte Mikrofonsignal zu entrauschen. Die Schätzung von spektralen Einhüllenden wurde bereits in der Vergangenheit erforscht und zum Teil auch für die Sprachverbesserung angewandt. Typischerweise wird dabei jedoch das Anregungssignal vernachlässigt, so dass die spektrale Feinstruktur des Mikrofonsignals nicht verbessert werden kann. Beide Ansätze nutzen jeweils die Eigenschaften der cepstralen Domäne, die unter anderem vorteilhafte mathematische Eigenschaften mit sich bringen, sowie die Möglichkeit, Prototypen eines Anregungssignals zu erzeugen. Wir untersuchen modellbasierte Ansätze, wie z.B. Gaußsche Mischmodelle, klassische signalverarbeitungsbasierte Lösungen und auch moderne tiefe neuronale Netzwerke in dieser Arbeit. Die so verbesserten Signale werden nicht direkt zur Sprachsignalverbesserung genutzt (z.B. Sprachsynthese), sondern als sogenannter A-priori-Signal-zu-Rauschleistungs-Schätzwert in einem traditionellen statistischen Sprachverbesserungssystem. Dieses besteht aus einem Störleistungs-Schätzer, einem A-priori-Signal-zu-Rauschleistungs-Schätzer und einer spektralen Gewichtungsregel, die üblicherweise mit Hilfe der Ergebnisse der beiden Schätzer berechnet wird. Schließlich wird eine Schätzung des sauberen Sprachsignals aus der Mikrofonaufnahme gewonnen. Der neue Ansatz bietet eine signifikant höhere Dämpfung des Störgeräuschs als der bisherige Stand der Technik. Dabei wird eine vergleichbare Qualität der Sprachkomponente und der Sprachverständlichkeit gewährleistet. Somit konnte die Gesamtqualität des verbesserten Sprachsignals gegenüber dem Stand der Technik erhöht werden