Optimizing the Stark-decelerator beamline for the trapping of cold molecules using evolutionary strategies

We demonstrate feedback control optimization for the Stark deceleration and trapping of neutral polar molecules using evolutionary strategies. In a Stark-decelerator beamline pulsed electric fields are used to decelerate OH radicals and subsequently store them in an electrostatic trap. The efficiency of the deceleration and trapping process is determined by the exact timings of the applied electric field pulses. Automated optimization of these timings yields an increase of 40 % of the number of trapped OH radicals.Comment: 7 pages, 4 figures (RevTeX) (v2) minor corrections (v3) no changes to manuscript, but fix author list in arXiv abstrac

Inference of population splits and mixtures from genome-wide allele frequency data

Many aspects of the historical relationships between populations in a species are reflected in genetic data. Inferring these relationships from genetic data, however, remains a challenging task. In this paper, we present a statistical model for inferring the patterns of population splits and mixtures in multiple populations. In this model, the sampled populations in a species are related to their common ancestor through a graph of ancestral populations. Using genome-wide allele frequency data and a Gaussian approximation to genetic drift, we infer the structure of this graph. We applied this method to a set of 55 human populations and a set of 82 dog breeds and wild canids. In both species, we show that a simple bifurcating tree does not fully describe the data; in contrast, we infer many migration events. While some of the migration events that we find have been detected previously, many have not. For example, in the human data we infer that Cambodians trace approximately 16% of their ancestry to a population ancestral to other extant East Asian populations. In the dog data, we infer that both the boxer and basenji trace a considerable fraction of their ancestry (9% and 25%, respectively) to wolves subsequent to domestication, and that East Asian toy breeds (the Shih Tzu and the Pekingese) result from admixture between modern toy breeds and "ancient" Asian breeds. Software implementing the model described here, called TreeMix, is available at http://treemix.googlecode.comComment: 28 pages, 6 figures in main text. Attached supplement is 22 pages, 15 figures. This is an updated version of the preprint available at http://precedings.nature.com/documents/6956/version/

Optimization and Prediction Techniques for Self-Healing and Self-Learning Applications in a Trustworthy Cloud Continuum

The current IT market is more and more dominated by the “cloud continuum”. In the “traditional” cloud, computing resources are typically homogeneous in order to facilitate economies of scale. In contrast, in edge computing, computational resources are widely diverse, commonly with scarce capacities and must be managed very efficiently due to battery constraints or other limitations. A combination of resources and services at the edge (edge computing), in the core (cloud computing), and along the data path (fog computing) is needed through a trusted cloud continuum. This requires novel solutions for the creation, optimization, management, and automatic operation of such infrastructure through new approaches such as infrastructure as code (IaC). In this paper, we analyze how artificial intelligence (AI)-based techniques and tools can enhance the operation of complex applications to support the broad and multi-stage heterogeneity of the infrastructural layer in the “computing continuum” through the enhancement of IaC optimization, IaC self-learning, and IaC self-healing. To this extent, the presented work proposes a set of tools, methods, and techniques for applications’ operators to seamlessly select, combine, configure, and adapt computation resources all along the data path and support the complete service lifecycle covering: (1) optimized distributed application deployment over heterogeneous computing resources; (2) monitoring of execution platforms in real time including continuous control and trust of the infrastructural services; (3) application deployment and adaptation while optimizing the execution; and (4) application self-recovery to avoid compromising situations that may lead to an unexpected failure.This research was funded by the European project PIACERE (Horizon 2020 research and innovation Program, under grant agreement no 101000162)