Computing Platforms for Big Biological Data Analytics: Perspectives and Challenges.

The last decade has witnessed an explosion in the amount of available biological sequence data, due to the rapid progress of high-throughput sequencing projects. However, the biological data amount is becoming so great that traditional data analysis platforms and methods can no longer meet the need to rapidly perform data analysis tasks in life sciences. As a result, both biologists and computer scientists are facing the challenge of gaining a profound insight into the deepest biological functions from big biological data. This in turn requires massive computational resources. Therefore, high performance computing (HPC) platforms are highly needed as well as efficient and scalable algorithms that can take advantage of these platforms. In this paper, we survey the state-of-the-art HPC platforms for big biological data analytics. We first list the characteristics of big biological data and popular computing platforms. Then we provide a taxonomy of different biological data analysis applications and a survey of the way they have been mapped onto various computing platforms. After that, we present a case study to compare the efficiency of different computing platforms for handling the classical biological sequence alignment problem. At last we discuss the open issues in big biological data analytics

Dwarfs on Accelerators: Enhancing OpenCL Benchmarking for Heterogeneous Computing Architectures

For reasons of both performance and energy efficiency, high-performance computing (HPC) hardware is becoming increasingly heterogeneous. The OpenCL framework supports portable programming across a wide range of computing devices and is gaining influence in programming next-generation accelerators. To characterize the performance of these devices across a range of applications requires a diverse, portable and configurable benchmark suite, and OpenCL is an attractive programming model for this purpose. We present an extended and enhanced version of the OpenDwarfs OpenCL benchmark suite, with a strong focus placed on the robustness of applications, curation of additional benchmarks with an increased emphasis on correctness of results and choice of problem size. Preliminary results and analysis are reported for eight benchmark codes on a diverse set of architectures -- three Intel CPUs, five Nvidia GPUs, six AMD GPUs and a Xeon Phi.Comment: 10 pages, 5 figure

Virtual Cluster Management for Analysis of Geographically Distributed and Immovable Data

Thesis (Ph.D.) - Indiana University, Informatics and Computing, 2015Scenarios exist in the era of Big Data where computational analysis needs to utilize widely distributed and remote compute clusters, especially when the data sources are sensitive or extremely large, and thus unable to move. A large dataset in Malaysia could be ecologically sensitive, for instance, and unable to be moved outside the country boundaries. Controlling an analysis experiment in this virtual cluster setting can be difficult on multiple levels: with setup and control, with managing behavior of the virtual cluster, and with interoperability issues across the compute clusters. Further, datasets can be distributed among clusters, or even across data centers, so that it becomes critical to utilize data locality information to optimize the performance of data-intensive jobs. Finally, datasets are increasingly sensitive and tied to certain administrative boundaries, though once the data has been processed, the aggregated or statistical result can be shared across the boundaries. This dissertation addresses management and control of a widely distributed virtual cluster having sensitive or otherwise immovable data sets through a controller. The Virtual Cluster Controller (VCC) gives control back to the researcher. It creates virtual clusters across multiple cloud platforms. In recognition of sensitive data, it can establish a single network overlay over widely distributed clusters. We define a novel class of data, notably immovable data that we call "pinned data", where the data is treated as a first-class citizen instead of being moved to where needed. We draw from our earlier work with a hierarchical data processing model, Hierarchical MapReduce (HMR), to process geographically distributed data, some of which are pinned data. The applications implemented in HMR use extended MapReduce model where computations are expressed as three functions: Map, Reduce, and GlobalReduce. Further, by facilitating information sharing among resources, applications, and data, the overall performance is improved. Experimental results show that the overhead of VCC is minimum. The HMR outperforms traditional MapReduce model while processing a particular class of applications. The evaluations also show that information sharing between resources and application through the VCC shortens the hierarchical data processing time, as well satisfying the constraints on the pinned data