169 research outputs found
Surrogate Modeling of Aerodynamic Simulations for Multiple Operating Conditions Using Machine Learning
International audienceThis paper describes a methodology, called local decomposition method, which aims at building a surrogate model based on steady turbulent aerodynamic fields at multiple operating conditions. The various shapes taken by the aerodynamic fields due to the multiple operation conditions pose real challenges as well as the computational cost of the high-fidelity simulations. The developed strategy mitigates these issues by combining traditional surrogate models and machine learning. The central idea is to separate the solutions with a subsonic behavior from the transonic and high-gradient solutions. First, a shock sensor extracts a feature corresponding to the presence of discontinuities, easing the clustering of the simulations by an unsupervised learning algorithm. Second, a supervised learning algorithm divides the parameter space into subdomains, associated to different flow regimes. Local reduced-order models are built on each subdomain using proper orthogonal decomposition coupled with a multivariate interpolation tool. Finally, an improved resampling technique taking advantage of the subdomain decomposition minimizes the redundancy of sampling. The methodology is assessed on the turbulent two-dimensional flow around the RAE2822 transonic airfoil. It exhibits a significant improvement in terms of prediction accuracy for the developed strategy compared with the classical method of surrogate modeling
Stochastic analysis of nonlinear dynamics and feedback control for gene regulatory networks with applications to synthetic biology
The focus of the thesis is the investigation of the generalized repressilator model
(repressing genes ordered in a ring structure). Using nonlinear bifurcation analysis
stable and quasi-stable periodic orbits in this genetic network are characterized
and a design for a switchable and controllable genetic oscillator is proposed. The
oscillator operates around a quasi-stable periodic orbit using the classical engineering
idea of read-out based control. Previous genetic oscillators have been
designed around stable periodic orbits, however we explore the possibility of
quasi-stable periodic orbit expecting better controllability.
The ring topology of the generalized repressilator model has spatio-temporal
symmetries that can be understood as propagating perturbations in discrete lattices.
Network topology is a universal cross-discipline transferable concept and
based on it analytical conditions for the emergence of stable and quasi-stable
periodic orbits are derived. Also the length and distribution of quasi-stable oscillations
are obtained. The findings suggest that long-lived transient dynamics
due to feedback loops can dominate gene network dynamics.
Taking the stochastic nature of gene expression into account a master equation
for the generalized repressilator is derived. The stochasticity is shown to influence
the onset of bifurcations and quality of oscillations. Internal noise is shown to
have an overall stabilizing effect on the oscillating transients emerging from the
quasi-stable periodic orbits.
The insights from the read-out based control scheme for the genetic oscillator
lead us to the idea to implement an algorithmic controller, which would direct
any genetic circuit to a desired state. The algorithm operates model-free, i.e. in
principle it is applicable to any genetic network and the input information is a
data matrix of measured time series from the network dynamics. The application
areas for readout-based control in genetic networks range from classical tissue
engineering to stem cells specification, whenever a quantitatively and temporarily
targeted intervention is required
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