Enhanced algorithms for lesion detection and recognition in ultrasound breast images

Mammography is the gold standard for breast cancer detection. However, it has very high false positive rates and is based on ionizing radiation. This has led to interest in using multi-modal approaches. One modality is diagnostic ultrasound, which is based on non-ionizing radiation and picks up many of the cancers that are generally missed by mammography. However, the presence of speckle noise in ultrasound images has a negative effect on image interpretation. Noise reduction, inconsistencies in capture and segmentation of lesions still remain challenging open research problems in ultrasound images. The target of the proposed research is to enhance the state-of-art computer vision algorithms used in ultrasound imaging and to investigate the role of computer processed images in human diagnostic performance. [Continues.

Advancements and Breakthroughs in Ultrasound Imaging

Ultrasonic imaging is a powerful diagnostic tool available to medical practitioners, engineers and researchers today. Due to the relative safety, and the non-invasive nature, ultrasonic imaging has become one of the most rapidly advancing technologies. These rapid advances are directly related to the parallel advancements in electronics, computing, and transducer technology together with sophisticated signal processing techniques. This book focuses on state of the art developments in ultrasonic imaging applications and underlying technologies presented by leading practitioners and researchers from many parts of the world

Automatic Segmentation and Classification of Red and White Blood cells in Thin Blood Smear Slides

In this work we develop a system for automatic detection and classification of cytological images which plays an increasing important role in medical diagnosis. A primary aim of this work is the accurate segmentation of cytological images of blood smears and subsequent feature extraction, along with studying related classification problems such as the identification and counting of peripheral blood smear particles, and classification of white blood cell into types five. Our proposed approach benefits from powerful image processing techniques to perform complete blood count (CBC) without human intervention. The general framework in this blood smear analysis research is as follows. Firstly, a digital blood smear image is de-noised using optimized Bayesian non-local means filter to design a dependable cell counting system that may be used under different image capture conditions. Then an edge preservation technique with Kuwahara filter is used to recover degraded and blurred white blood cell boundaries in blood smear images while reducing the residual negative effect of noise in images. After denoising and edge enhancement, the next step is binarization using combination of Otsu and Niblack to separate the cells and stained background. Cells separation and counting is achieved by granulometry, advanced active contours without edges, and morphological operators with watershed algorithm. Following this is the recognition of different types of white blood cells (WBCs), and also red blood cells (RBCs) segmentation. Using three main types of features: shape, intensity, and texture invariant features in combination with a variety of classifiers is next step. The following features are used in this work: intensity histogram features, invariant moments, the relative area, co-occurrence and run-length matrices, dual tree complex wavelet transform features, Haralick and Tamura features. Next, different statistical approaches involving correlation, distribution and redundancy are used to measure of the dependency between a set of features and to select feature variables on the white blood cell classification. A global sensitivity analysis with random sampling-high dimensional model representation (RS-HDMR) which can deal with independent and dependent input feature variables is used to assess dominate discriminatory power and the reliability of feature which leads to an efficient feature selection. These feature selection results are compared in experiments with branch and bound method and with sequential forward selection (SFS), respectively. This work examines support vector machine (SVM) and Convolutional Neural Networks (LeNet5) in connection with white blood cell classification. Finally, white blood cell classification system is validated in experiments conducted on cytological images of normal poor quality blood smears. These experimental results are also assessed with ground truth manually obtained from medical experts

Automated retinal layer segmentation and pre-apoptotic monitoring for three-dimensional optical coherence tomography

The aim of this PhD thesis was to develop segmentation algorithm adapted and optimized to retinal OCT data that will provide objective 3D layer thickness which might be used to improve diagnosis and monitoring of retinal pathologies. Additionally, a 3D stack registration method was produced by modifying an existing algorithm. A related project was to develop a pre-apoptotic retinal monitoring based on the changes in texture parameters of the OCT scans in order to enable treatment before the changes become irreversible; apoptosis refers to the programmed cell death that can occur in retinal tissue and lead to blindness. These issues can be critical for the examination of tissues within the central nervous system. A novel statistical model for segmentation has been created and successfully applied to a large data set. A broad range of future research possibilities into advanced pathologies has been created by the results obtained. A separate model has been created for choroid segmentation located deep in retina, as the appearance of choroid is very different from the top retinal layers. Choroid thickness and structure is an important index of various pathologies (diabetes etc.). As part of the pre-apoptotic monitoring project it was shown that an increase in proportion of apoptotic cells in vitro can be accurately quantified. Moreover, the data obtained indicates a similar increase in neuronal scatter in retinal explants following axotomy (removal of retinas from the eye), suggesting that UHR-OCT can be a novel non-invasive technique for the in vivo assessment of neuronal health. Additionally, an independent project within the computer science department in collaboration with the school of psychology has been successfully carried out, improving analysis of facial dynamics and behaviour transfer between individuals. Also, important improvements to a general signal processing algorithm, dynamic time warping (DTW), have been made, allowing potential application in a broad signal processing field.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Automated retinal layer segmentation and pre-apoptotic monitoring for three-dimensional optical coherence tomography

The aim of this PhD thesis was to develop segmentation algorithm adapted and optimized to retinal OCT data that will provide objective 3D layer thickness which might be used to improve diagnosis and monitoring of retinal pathologies. Additionally, a 3D stack registration method was produced by modifying an existing algorithm. A related project was to develop a pre-apoptotic retinal monitoring based on the changes in texture parameters of the OCT scans in order to enable treatment before the changes become irreversible; apoptosis refers to the programmed cell death that can occur in retinal tissue and lead to blindness. These issues can be critical for the examination of tissues within the central nervous system. A novel statistical model for segmentation has been created and successfully applied to a large data set. A broad range of future research possibilities into advanced pathologies has been created by the results obtained. A separate model has been created for choroid segmentation located deep in retina, as the appearance of choroid is very different from the top retinal layers. Choroid thickness and structure is an important index of various pathologies (diabetes etc.). As part of the pre-apoptotic monitoring project it was shown that an increase in proportion of apoptotic cells in vitro can be accurately quantified. Moreover, the data obtained indicates a similar increase in neuronal scatter in retinal explants following axotomy (removal of retinas from the eye), suggesting that UHR-OCT can be a novel non-invasive technique for the in vivo assessment of neuronal health. Additionally, an independent project within the computer science department in collaboration with the school of psychology has been successfully carried out, improving analysis of facial dynamics and behaviour transfer between individuals. Also, important improvements to a general signal processing algorithm, dynamic time warping (DTW), have been made, allowing potential application in a broad signal processing field

Geometric Expression Invariant 3D Face Recognition using Statistical Discriminant Models

Currently there is no complete face recognition system that is invariant to all facial expressions. Although humans find it easy to identify and recognise faces regardless of changes in illumination, pose and expression, producing a computer system with a similar capability has proved to be particularly di cult. Three dimensional face models are geometric in nature and therefore have the advantage of being invariant to head pose and lighting. However they are still susceptible to facial expressions. This can be seen in the decrease in the recognition results using principal component analysis when expressions are added to a data set. In order to achieve expression-invariant face recognition systems, we have employed a tensor algebra framework to represent 3D face data with facial expressions in a parsimonious space. Face variation factors are organised in particular subject and facial expression modes. We manipulate this using single value decomposition on sub-tensors representing one variation mode. This framework possesses the ability to deal with the shortcomings of PCA in less constrained environments and still preserves the integrity of the 3D data. The results show improved recognition rates for faces and facial expressions, even recognising high intensity expressions that are not in the training datasets. We have determined, experimentally, a set of anatomical landmarks that best describe facial expression e ectively. We found that the best placement of landmarks to distinguish di erent facial expressions are in areas around the prominent features, such as the cheeks and eyebrows. Recognition results using landmark-based face recognition could be improved with better placement. We looked into the possibility of achieving expression-invariant face recognition by reconstructing and manipulating realistic facial expressions. We proposed a tensor-based statistical discriminant analysis method to reconstruct facial expressions and in particular to neutralise facial expressions. The results of the synthesised facial expressions are visually more realistic than facial expressions generated using conventional active shape modelling (ASM). We then used reconstructed neutral faces in the sub-tensor framework for recognition purposes. The recognition results showed slight improvement. Besides biometric recognition, this novel tensor-based synthesis approach could be used in computer games and real-time animation applications

Information Preserving Processing of Noisy Handwritten Document Images

Many pre-processing techniques that normalize artifacts and clean noise induce anomalies due to discretization of the document image. Important information that could be used at later stages may be lost. A proposed composite-model framework takes into account pre-printed information, user-added data, and digitization characteristics. Its benefits are demonstrated by experiments with statistically significant results. Separating pre-printed ruling lines from user-added handwriting shows how ruling lines impact people\u27s handwriting and how they can be exploited for identifying writers. Ruling line detection based on multi-line linear regression reduces the mean error of counting them from 0.10 to 0.03, 6.70 to 0.06, and 0.13 to 0.02, com- pared to an HMM-based approach on three standard test datasets, thereby reducing human correction time by 50%, 83%, and 72% on average. On 61 page images from 16 rule-form templates, the precision and recall of form cell recognition are increased by 2.7% and 3.7%, compared to a cross-matrix approach. Compensating for and exploiting ruling lines during feature extraction rather than pre-processing raises the writer identification accuracy from 61.2% to 67.7% on a 61-writer noisy Arabic dataset. Similarly, counteracting page-wise skew by subtracting it or transforming contours in a continuous coordinate system during feature extraction improves the writer identification accuracy. An implementation study of contour-hinge features reveals that utilizing the full probabilistic probability distribution function matrix improves the writer identification accuracy from 74.9% to 79.5%