1,311 research outputs found
Variational Analysis in Nonsmooth Optimization and Discrete Optimal Control
The paper is devoted to applications of modern methods of variational· analysis to constrained optimization and control problems generally formulated in infinite-dimensional spaces. The main attention is paid to the study of problems with nonsmooth structures, which require the usage of advanced tools of generalized differentiation. In this way we derive new necessary optimality conditions in optimization problems with functional and. operator constraints and then apply them to optimal control problems governed by discrete-time inclusions in infinite dimensions. The principal difference between finite-dimensional and infinite-dimensional frameworks of optimization and control consists of the lack of compactness in infinite dimensions, which leads to imposing certain normal compactness properties and developing their comprehensive calculus, together with appropriate calculus rules of generalized differentiation. On the other hand, one of the most important achievements of the paper consists of relaxing the latter assumptions for certain classes of optimization and control problems. In particular, we fully avoid the requirements of this type imposed on target endpoint sets in infinite-dimensional optimal control for discrete-time inclusions
A user's manual for the Automatic Synthesis Program /program C/
Digital computer program for numerical solution of problems in system theory involving linear mathematic
Knowledge-based energy functions for computational studies of proteins
This chapter discusses theoretical framework and methods for developing
knowledge-based potential functions essential for protein structure prediction,
protein-protein interaction, and protein sequence design. We discuss in some
details about the Miyazawa-Jernigan contact statistical potential,
distance-dependent statistical potentials, as well as geometric statistical
potentials. We also describe a geometric model for developing both linear and
non-linear potential functions by optimization. Applications of knowledge-based
potential functions in protein-decoy discrimination, in protein-protein
interactions, and in protein design are then described. Several issues of
knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe
Generalized Maximum Entropy, Convexity and Machine Learning
This thesis identifies and extends techniques that can be linked to the principle of maximum entropy (maxent) and applied to parameter estimation in machine learning and statistics. Entropy functions based on deformed logarithms are used to construct Bregman divergences, and together these represent a generalization of relative entropy. The framework is analyzed using convex analysis to charac- terize generalized forms of exponential family distributions. Various connections to the existing machine learning literature are discussed and the techniques are applied to the problem of non-negative matrix factorization (NMF)
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