Optimal control of a reaction-diffusion model related to the spread of COVID-19

This paper is concerned with the well-posedness and optimal control problem of a reaction-diffusion system for an epidemic Susceptible-Infected-Recovered-Susceptible (SIRS) mathematical model in which the dynamics develops in a spatially heterogeneous environment. Using as control variables the transmission rates $u_{i}$ and $u_{e}$ of contagion resulting from the contact with both asymptomatic and symptomatic persons, respectively, we optimize the number of exposed and infected individuals at a final time $T$ of the controlled evolution of the system. More precisely, we search for the optimal $u_{i}$ and $u_{e}$ such that the number of infected plus exposed does not exceed at the final time a threshold value $\Lambda$, fixed a priori. We prove here the existence of optimal controls in a proper functional framework and we derive the first-order necessary optimality conditions in terms of the adjoint variables.Comment: Keywords: COVID-19, partial differential equations, reaction-diffusion system, epidemic models, existence of solutions, uniqueness, optimal contro

Efficient community-based control strategies in adaptive networks

Most researches on adaptive networks mainly concentrate on the properties of steady state, but neglect transient dynamics. In this study, we pay attention to the emergence of community structures in transient process and the effects of community-based control strategies on epidemic spreading. First, by normalizing modularity $Q$, we investigate the evolution of community structures during the transient process, and find that very strong community structures are induced by rewiring mechanism in the early stage of epidemic spreading, which remarkably delays the outbreaks of epidemic. Then we study the effects of control strategies started from different stages on the prevalence. Both immunization and quarantine strategies indicate that it is not "the earlier, the better" for the implementing of control measures. And the optimal control effect is obtained if control measures can be efficiently implemented in the period of strong community structure. For immunization strategy, immunizing the S nodes on SI links and immunizing S nodes randomly have similar control effects. Yet for quarantine strategy, quarantining the I nodes on SI links can yield far better effects than quarantining I nodes randomly. More significantly, community-based quarantine strategy plays more efficient performance than community-based immunization strategy. This study may shed new lights on the forecast and the prevention of epidemic among human population.Comment: 5 pages, 5 figure

Optimal Control of Epidemics in the Presence of Heterogeneity

We seek to identify and address how different types of heterogeneity affect the optimal control of epidemic processes in social, biological, and computer networks. Epidemic processes encompass a variety of models of propagation that are based on contact between agents. Assumptions of homogeneity of communication rates, resources, and epidemics themselves in prior literature gloss over the heterogeneities inherent to such networks and lead to the design of sub-optimal control policies. However, the added complexity that comes with a more nuanced view of such networks complicates the generalizing of most prior work and necessitates the use of new analytical methods. We first create a taxonomy of heterogeneity in the spread of epidemics. We then model the evolution of heterogeneous epidemics in the realms of biology and sociology, as well as those arising from practice in the fields of communication networks (e.g., DTN message routing) and security (e.g., malware spread and patching). In each case, we obtain computational frameworks using Pontryagin’s Maximum Principle that will lead to the derivation of dynamic controls that optimize general, context-specific objectives. We then prove structures for each of these vectors of optimal controls that can simplify the derivation, storage, and implementation of optimal policies. Finally, using simulations and real-world traces, we examine the benefits achieved by including heterogeneity in the control decision, as well as the sensitivity of the models and the controls to model parameters in each case

Modeling and Control for HIV/AIDS Transmission in China Based on Data from 2004 to 2016

HIV is one of the major life-threatening viruses that are spreading in the People’s Republic of China (China for short). A susceptible-exposed in the latent stage-infectious (SEI) model is established to sketch the evolution of epidemic. The basic reproduction number is defined. By constructing Lyapunov function, globally asymptotical stabilities of the disease-free and endemic equilibria are given. Then, optimal control theory is applied in HIV/AIDS epidemic. Precaution, screening, and treatment of control variables are introduced and a new model with control is established. Through the HIV/AIDS data in China, all parameters involved in SEI model are analyzed and parts of them are estimated. Further, by control model, optimal strategy is obtained. Results show that the precaution and treatment are the major contributors to preventing and controlling HIV/AIDS epidemic

How to Run a Campaign: Optimal Control of SIS and SIR Information Epidemics

Information spreading in a population can be modeled as an epidemic. Campaigners (e.g. election campaign managers, companies marketing products or movies) are interested in spreading a message by a given deadline, using limited resources. In this paper, we formulate the above situation as an optimal control problem and the solution (using Pontryagin's Maximum Principle) prescribes an optimal resource allocation over the time of the campaign. We consider two different scenarios --- in the first, the campaigner can adjust a direct control (over time) which allows her to recruit individuals from the population (at some cost) to act as spreaders for the Susceptible-Infected-Susceptible (SIS) epidemic model. In the second case, we allow the campaigner to adjust the effective spreading rate by incentivizing the infected in the Susceptible-Infected-Recovered (SIR) model, in addition to the direct recruitment. We consider time varying information spreading rate in our formulation to model the changing interest level of individuals in the campaign, as the deadline is reached. In both the cases, we show the existence of a solution and its uniqueness for sufficiently small campaign deadlines. For the fixed spreading rate, we show the effectiveness of the optimal control strategy against the constant control strategy, a heuristic control strategy and no control. We show the sensitivity of the optimal control to the spreading rate profile when it is time varying.Comment: Proofs for Theorems 4.2 and 5.2 which do not appear in the published journal version are included in this version. Published version can be accessed here: http://dx.doi.org/10.1016/j.amc.2013.12.16

Optimal Control to Limit the Propagation Effect of a Virus Outbreak on a Network

The aim of this paper is to propose an optimal control strategy to face the propagation effects of a virus outbreak on a network; a recently proposed model is integrated and analysed. Depending on the specific model caracteristics, the epidemic spread could be more or less dangerous leading to a virus free or to a virus equilibrium. Two possible controls are introduced: a test on the computers connected in a network and the antivirus. In a condition of limited resources the best allocation strategy should allow to reduce the spread of the virus as soon as possible

Analysis, Simulation and Control of a New Measles Epidemic Model

In this paper the problem of modeling and controlling the measles epidemic spread is faced. A new model is proposed and analysed; besides the categories usually considered in measles modeling, the susceptible, the exposed, the infected, the removed and, less frequently, the quarantine individuals, two new categories are herein introduced: the immunosuppressed subjects, that can not be vaccinated, and the patients with an additional complication, not risky by itself but dangerous if caught togeter with the measles. These two novelties are taken into account in designing and scheduling suitably control actions such as vaccination, whenever possible, prevention, quarantine and treatment, when limited resources are available. An analysis of the model is developed and the optimal control strategies are compared with other not optimized actions. By using the Pontryagin principle, it is shown the prevailing role of the vaccination in guaranteeing the protection to immunosuppressed individuals, as well as the importance of a prompt response of the society when an epidemic spread occurs, such as the quarantine intervention