A Convex Framework for Epidemic Control in Networks

With networks becoming pervasive, research attention on dynamics of epidemic models in networked populations has increased. While a number of well understood epidemic spreading models have been developed, little to no attention has been paid to epidemic control strategies; beyond heuristics usually based on network centrality measures. Since epidemic control resources are typically limited, the problem of optimally allocating resources to control an outbreak becomes of interest. Existing literature considered homogeneous networks, limited the discussion to undirected networks, and largely proposed network centrality-based resource allocation strategies. In this thesis, we consider the well-known Susceptible-Infected-Susceptible spreading model and study the problem of minimum cost resource allocation to control an epidemic outbreak in a networked population. First, we briefly present a heuristic that outperforms network centrality-based algorithms on a stylized version of the problem previously studied in the literature. We then solve the epidemic control problem via a convex optimization framework on weighted, directed networks comprising heterogeneous nodes. Based on our spreading model, we express the problem of controlling an epidemic outbreak in terms of spectral conditions involving the Perron-Frobenius eigenvalue. This enables formulation of the epidemic control problem as a Geometric Program (GP), for which we derive a convex characterization guaranteeing existence of an optimal solution. We consider two formulations of the epidemic control problem -- the first seeks an optimal vaccine and antidote allocation strategy given a constraint on the rate at which the epidemic comes under control. The second formulation seeks to find an optimal allocation strategy given a budget on the resources. The solution framework for both formulations also allows for control of an epidemic outbreak on networks that are not necessarily strongly connected. The thesis further proposes a fully distributed solution to the epidemic control problem via a Distributed Alternating Direction Method of Multipliers (ADMM) algorithm. Our distributed solution enables each node to locally compute its optimum allocation of vaccines and antidotes needed to collectively globally contain the spread of an outbreak, via local exchange of information with its neighbors. Contrasting previous literature, our problem is a constrained optimization problem associated with a directed network comprising non-identical agents. For the different problem formulations considered, illustrations that validate our solutions are presented. This thesis, in sum, proposes a paradigm shift from heuristics towards a convex framework for contagion control in networked populations

Optimal Vaccine Allocation to Control Epidemic Outbreaks in Arbitrary Networks

We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network. We analyze a networked version of the Susceptible-Infected-Susceptible (SIS) epidemic model when individuals in the network present different levels of susceptibility to the epidemic. In this context, controlling the spread of an epidemic outbreak can be written as a spectral condition involving the eigenvalues of a matrix that depends on the network structure and the parameters of the model. We study the problem of finding the optimal distribution of vaccines throughout the network to control the spread of an epidemic outbreak. We propose a convex framework to find cost-optimal distribution of vaccination resources when different levels of vaccination are allowed. We also propose a greedy approach with quality guarantees for the case of all-or-nothing vaccination. We illustrate our approaches with numerical simulations in a real social network

Optimal Resource Allocation Over Time and Degree Classes for Maximizing Information Dissemination in Social Networks

We study the optimal control problem of allocating campaigning resources over the campaign duration and degree classes in a social network. Information diffusion is modeled as a Susceptible-Infected epidemic and direct recruitment of susceptible nodes to the infected (informed) class is used as a strategy to accelerate the spread of information. We formulate an optimal control problem for optimizing a net reward function, a linear combination of the reward due to information spread and cost due to application of controls. The time varying resource allocation and seeds for the epidemic are jointly optimized. A problem variation includes a fixed budget constraint. We prove the existence of a solution for the optimal control problem, provide conditions for uniqueness of the solution, and prove some structural results for the controls (e.g. controls are non-increasing functions of time). The solution technique uses Pontryagin's Maximum Principle and the forward-backward sweep algorithm (and its modifications) for numerical computations. Our formulations lead to large optimality systems with up to about 200 differential equations and allow us to study the effect of network topology (Erdos-Renyi/scale-free) on the controls. Results reveal that the allocation of campaigning resources to various degree classes depends not only on the network topology but also on system parameters such as cost/abundance of resources. The optimal strategies lead to significant gains over heuristic strategies for various model parameters. Our modeling approach assumes uncorrelated network, however, we find the approach useful for real networks as well. This work is useful in product advertising, political and crowdfunding campaigns in social networks.Comment: 14 + 4 pages, 11 figures. Author's version of the article accepted for publication in IEEE/ACM Transactions on Networking. This version includes 4 pages of supplementary material containing proofs of theorems present in the article. Published version can be accessed at http://dx.doi.org/10.1109/TNET.2015.251254