An Automated System for Epilepsy Detection using EEG Brain Signals based on Deep Learning Approach

Epilepsy is a neurological disorder and for its detection, encephalography (EEG) is a commonly used clinical approach. Manual inspection of EEG brain signals is a time-consuming and laborious process, which puts heavy burden on neurologists and affects their performance. Several automatic techniques have been proposed using traditional approaches to assist neurologists in detecting binary epilepsy scenarios e.g. seizure vs. non-seizure or normal vs. ictal. These methods do not perform well when classifying ternary case e.g. ictal vs. normal vs. inter-ictal; the maximum accuracy for this case by the state-of-the-art-methods is 97+-1%. To overcome this problem, we propose a system based on deep learning, which is an ensemble of pyramidal one-dimensional convolutional neural network (P-1D-CNN) models. In a CNN model, the bottleneck is the large number of learnable parameters. P-1D-CNN works on the concept of refinement approach and it results in 60% fewer parameters compared to traditional CNN models. Further to overcome the limitations of small amount of data, we proposed augmentation schemes for learning P-1D-CNN model. In almost all the cases concerning epilepsy detection, the proposed system gives an accuracy of 99.1+-0.9% on the University of Bonn dataset.Comment: 18 page

Dynamical Component Analysis (DyCA) and its application on epileptic EEG

Dynamical Component Analysis (DyCA) is a recently-proposed method to detect projection vectors to reduce the dimensionality of multi-variate deterministic datasets. It is based on the solution of a generalized eigenvalue problem and therefore straight forward to implement. DyCA is introduced and applied to EEG data of epileptic seizures. The obtained eigenvectors are used to project the signal and the corresponding trajectories in phase space are compared with PCA and ICA-projections. The eigenvalues of DyCA are utilized for seizure detection and the obtained results in terms of specificity, false discovery rate and miss rate are compared to other seizure detection algorithms.Comment: 5 pages, 4 figures, accepted for IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) 201

Neonatal Seizure Detection using Convolutional Neural Networks

This study presents a novel end-to-end architecture that learns hierarchical representations from raw EEG data using fully convolutional deep neural networks for the task of neonatal seizure detection. The deep neural network acts as both feature extractor and classifier, allowing for end-to-end optimization of the seizure detector. The designed system is evaluated on a large dataset of continuous unedited multi-channel neonatal EEG totaling 835 hours and comprising of 1389 seizures. The proposed deep architecture, with sample-level filters, achieves an accuracy that is comparable to the state-of-the-art SVM-based neonatal seizure detector, which operates on a set of carefully designed hand-crafted features. The fully convolutional architecture allows for the localization of EEG waveforms and patterns that result in high seizure probabilities for further clinical examination.Comment: IEEE International Workshop on Machine Learning for Signal Processin

A Hidden Markov Factor Analysis Framework for Seizure Detection in Epilepsy Patients

Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy. Detection of seizure from the recorded EEG is a laborious, time consuming and expensive task. In this study, we propose an automated seizure detection framework to assist electroencephalographers and physicians with identification of seizures in recorded EEG signals. In addition, an automated seizure detection algorithm can be used for treatment through automatic intervention during the seizure activity and on time triggering of the injection of a radiotracer to localize the seizure activity. In this study, we developed and tested a hidden Markov factor analysis (HMFA) framework for automated seizure detection based on different features such as total effective inflow which is calculated based on connectivity measures between different sites of the brain. The algorithm was tested on long-term (2.4-7.66 days) continuous sEEG recordings from three patients and a total of 16 seizures, producing a mean sensitivity of 96.3% across all seizures, a mean specificity of 3.47 false positives per hour, and a mean latency of 3.7 seconds form the actual seizure onset. The latency was negative for a few of the seizures which implies the proposed method detects the seizure prior to its onset. This is an indication that with some extension the proposed method is capable of seizure prediction