19,728 research outputs found
Prospects for Theranostics in Neurosurgical Imaging: Empowering Confocal Laser Endomicroscopy Diagnostics via Deep Learning
Confocal laser endomicroscopy (CLE) is an advanced optical fluorescence
imaging technology that has the potential to increase intraoperative precision,
extend resection, and tailor surgery for malignant invasive brain tumors
because of its subcellular dimension resolution. Despite its promising
diagnostic potential, interpreting the gray tone fluorescence images can be
difficult for untrained users. In this review, we provide a detailed
description of bioinformatical analysis methodology of CLE images that begins
to assist the neurosurgeon and pathologist to rapidly connect on-the-fly
intraoperative imaging, pathology, and surgical observation into a
conclusionary system within the concept of theranostics. We present an overview
and discuss deep learning models for automatic detection of the diagnostic CLE
images and discuss various training regimes and ensemble modeling effect on the
power of deep learning predictive models. Two major approaches reviewed in this
paper include the models that can automatically classify CLE images into
diagnostic/nondiagnostic, glioma/nonglioma, tumor/injury/normal categories and
models that can localize histological features on the CLE images using weakly
supervised methods. We also briefly review advances in the deep learning
approaches used for CLE image analysis in other organs. Significant advances in
speed and precision of automated diagnostic frame selection would augment the
diagnostic potential of CLE, improve operative workflow and integration into
brain tumor surgery. Such technology and bioinformatics analytics lend
themselves to improved precision, personalization, and theranostics in brain
tumor treatment.Comment: See the final version published in Frontiers in Oncology here:
https://www.frontiersin.org/articles/10.3389/fonc.2018.00240/ful
Bridges Structural Health Monitoring and Deterioration Detection Synthesis of Knowledge and Technology
INE/AUTC 10.0
Apollo experience report: Development of the extravehicular mobility unit
The development and performance history of the Apollo extravehicular mobility unit and its major subsystems is described. The three major subsystems, the pressure garment assembly, the portable life-support system, and the oxygen purge system, are defined and described in detail as is the evolutionary process that culminated in each major subsystem component. Descriptions of ground-support equipment and the qualification testing process for component hardware are also presented
Internet of Things-aided Smart Grid: Technologies, Architectures, Applications, Prototypes, and Future Research Directions
Traditional power grids are being transformed into Smart Grids (SGs) to
address the issues in existing power system due to uni-directional information
flow, energy wastage, growing energy demand, reliability and security. SGs
offer bi-directional energy flow between service providers and consumers,
involving power generation, transmission, distribution and utilization systems.
SGs employ various devices for the monitoring, analysis and control of the
grid, deployed at power plants, distribution centers and in consumers' premises
in a very large number. Hence, an SG requires connectivity, automation and the
tracking of such devices. This is achieved with the help of Internet of Things
(IoT). IoT helps SG systems to support various network functions throughout the
generation, transmission, distribution and consumption of energy by
incorporating IoT devices (such as sensors, actuators and smart meters), as
well as by providing the connectivity, automation and tracking for such
devices. In this paper, we provide a comprehensive survey on IoT-aided SG
systems, which includes the existing architectures, applications and prototypes
of IoT-aided SG systems. This survey also highlights the open issues,
challenges and future research directions for IoT-aided SG systems
M.I.N.G., Mars Investment for a New Generation: Robotic construction of a permanently manned Mars base
A basic procedure for robotically constructing a manned Mars base is outlined. The research procedure was divided into three areas: environment, robotics, and habitat. The base as designed will consist of these components: two power plants, communication facilities, a habitat complex, and a hangar, a garage, recreation and manufacturing facilities. The power plants will be self-contained nuclear fission reactors placed approx. 1 km from the base for safety considerations. The base communication system will use a combination of orbiting satellites and surface relay stations. This system is necessary for robotic contact with Phobos and any future communication requirements. The habitat complex will consist of six self-contained modules: core, biosphere, science, living quarters, galley/storage, and a sick bay which will be brought from Phobos. The complex will be set into an excavated hole and covered with approximately 0.5 m of sandbags to provide radiation protection for the astronauts. The recreation, hangar, garage, and manufacturing facilities will each be transformed from the four one-way landers. The complete complex will be built by autonomous, artificially intelligent robots. Robots incorporated into the design are as follows: Large Modular Construction Robots with detachable arms capable of large scale construction activities; Small Maneuverable Robotic Servicers capable of performing delicate tasks normally requiring a suited astronaut; and a trailer vehicle with modular type attachments to complete specific tasks; and finally, Mobile Autonomous Rechargeable Transporters capable of transferring air and water from the manufacturing facility to the habitat complex
SIRTF Telescope Instrument Changeout and Cryogen Replenishment (STICCR) Study
The Space Infrared Telescope Facility (SIRTF) is a long-life cryogenically cooled space-based telescope for infrared astronomy from 2 to 700 micrometers. SIRTF is currently under study by NASA-ARC (Reference AP) and planned for launch in approximately the mid 1990s. SIRTF will operate as a multiuser facility, initially carrying three instruments at the focal plane. It will be cooled to below 2 K by superfluid liquid helium to achieve radiometric sensitivity limited only by the statistical fluctuations in the natural infrared background radiation over most of its spectral range. The lifetime of the mission will be limited by the lifetime of the liquid helium supply, and baseline is currently to be 2 years. The telescope changes required to allow in-space replenishment of the 4,000-L superfluid helium tank was investigated. A preliminary design for the space services equipment was also developed. The impacts of basing the equipment and servicing on the space station were investigated. Space replenishment and changeout of instruments required changes to the telescope design. Preliminary concepts are presented
Communications
The communications sector of an economy comprises a range of technologies, physical media, and institutions/rules that facilitate the storage of information through means other than a society\u27s oral tradition and the transmission of that information over distances beyond the normal reach of human conversation. This chapter provides data on the historical evolution of a disparate range of industries and institutions contributing to the movement and storage of information in the United States over the past two centuries. These include the U.S. Postal Service, the newspaper industry, book publishing, the telegraph, wired and cellular telephone service, radio and television, and the Internet
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